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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:250.7 nTPM
HPA:250.7 nTPM
GTEx:214.7 nTPM
FANTOM5:338.5 Scaled Tags Per Million
Pig:62.3 nTPM
Mouse:48.4 nTPM
Allen mouse:2.4 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 250.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 217.7
1830 Male, age 51, unknown 250.4
2411 Female, age 72, unknown 247.7
1870 Female, age 42, unknown 238.6
1833 Male, age 53, unknown 236.7
2019 Male, age 18, unknown 227.4
2828 Female, age 72, unknown 205.6
2666 Male, age 74, left hemisphere 202.7
2586 Male, age 75, left hemisphere 196.1
1827 Male, age 72, unknown 190.8
2219 Male, age 76, both hemispheres 181.5
Dorsal raphe nucleus
nTPM: 202.6
2750 Male, age 76, both hemispheres 265.0
2016 Female, age 72, unknown 200.3
1828 Male, age 53, unknown 194.4
2298 Female, age 72, unknown 176.9
2047 Male, age 72, unknown 176.4
Inferior colliculus
nTPM: 178.3
1890 Male, age 53, unknown 183.7
1848 Female, age 42, unknown 178.2
2849 Male, age 72, unknown 177.2
2097 Female, age 72, unknown 174.0
Median raphe nucleus
nTPM: 192.5
2220 Male, age 76, midline 192.5
Pedunculopontine tegmental nucleus
nTPM: 202.5
2334 Male, age 80, both hemispheres 219.9
1921 Female, age 85, both hemispheres 195.8
2338 Male, age 61, both hemispheres 191.9
Periaquaductal grey, anterior
nTPM: 184.9
2502 Female, age 75, unknown 198.1
1947 Male, age 18, unknown 182.7
1795 Male, age 51, unknown 173.8
Periaquaductal grey, dorsal
nTPM: 176.1
2464 Female, age 72, unknown 202.1
1831 Male, age 72, unknown 181.1
1840 Male, age 53, unknown 161.0
2850 Male, age 76, both hemispheres 160.2
Periaquaductal grey, lateral
nTPM: 178.2
2053 Male, age 18, unknown 193.5
2272 Male, age 74, both hemispheres 180.0
2140 Male, age 76, both hemispheres 161.1
Pretectal area
nTPM: 184.6
2316 Male, age 76, right hemisphere 225.3
1815 Male, age 53, unknown 201.0
2407 Male, age 75, both hemispheres 198.6
2825 Male, age 18, unknown 192.8
1817 Female, age 42, unknown 186.9
2273 Male, age 74, both hemispheres 183.1
2224 Female, age 72, unknown 178.8
2007 Male, age 72, unknown 178.4
2667 Female, age 75, unknown 172.7
1816 Male, age 51, unknown 158.1
1944 Female, age 72, unknown 155.0
Red nucleus
nTPM: 250.7
2823 Male, age 76, right hemisphere 275.6
1865 Male, age 51, unknown 274.2
1904 Male, age 53, unknown 269.2
1821 Female, age 72, unknown 269.0
2503 Female, age 72, unknown 261.7
2769 Male, age 72, unknown 257.1
2227 Male, age 72, unknown 256.8
2588 Male, age 74, left hemisphere 253.1
1954 Female, age 42, unknown 239.3
2785 Male, age 18, unknown 234.0
2725 Female, age 75, unknown 213.2
2584 Male, age 75, left hemisphere 204.6
Substantia nigra
nTPM: 198.1
2590 Female, age 75, unknown 218.9
1851 Male, age 51, unknown 213.1
2409 Female, age 72, unknown 212.2
2699 Male, age 18, unknown 201.9
2241 Male, age 72, unknown 200.7
2583 Male, age 75, right hemisphere 196.4
1889 Female, age 72, unknown 192.2
2665 Male, age 74, both hemispheres 189.3
1941 Male, age 53, unknown 181.0
1916 Female, age 42, unknown 175.8
Superior colliculus
nTPM: 205.6
1913 Female, age 42, unknown 252.0
1995 Male, age 72, unknown 240.6
1895 Male, age 76, right hemisphere 223.2
2587 Male, age 74, left hemisphere 222.3
2668 Female, age 75, unknown 206.1
1839 Male, age 51, unknown 200.4
1796 Male, age 53, unknown 187.4
2664 Male, age 75, both hemispheres 182.6
2261 Male, age 18, unknown 172.2
2087 Female, age 72, unknown 169.6
Ventral tegmental area
nTPM: 208.5
2223 Female, age 72, unknown 229.5
2410 Female, age 72, unknown 226.8
2021 Male, age 53, unknown 208.2
1942 Male, age 51, unknown 201.4
1915 Female, age 42, unknown 195.4
2218 Male, age 76, both hemispheres 189.7

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 214.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 214.7
Samples: 139

Max nTPM: 594.9
Min nTPM: 65.0
Std nTPM: 87.6
Median nTPM: 187.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 594.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 467.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 449.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 408.7
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 389.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 377.8
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 372.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 359.9
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 353.5
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 352.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 339.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 336.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 333.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 331.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 331.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 329.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 329.4
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 328.3
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 324.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 324.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 321.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 321.7
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 310.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 298.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 295.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 293.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 291.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 284.0
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 278.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 276.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 274.1
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 273.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 271.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 270.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 269.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 269.3
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 265.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 261.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 260.0
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 254.0
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 251.7
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 250.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 250.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 249.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 246.7
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 246.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 246.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 245.2
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 244.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 236.9
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 233.2
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 228.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 225.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 224.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 223.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 222.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 222.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 214.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 212.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 210.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 210.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 209.4
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 205.0
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 200.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 200.3
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 194.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 192.9
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 191.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 190.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 187.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 186.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 186.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 185.2
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 185.0
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 184.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 182.8
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 182.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 182.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 182.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 182.0
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 178.1
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 175.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 174.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 174.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 174.1
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 170.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 170.2
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 169.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 169.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 168.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 166.8
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 164.0
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 163.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 161.0
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 160.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 158.2
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 157.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 157.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 157.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 156.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 155.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 154.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 152.6
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 151.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 148.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 147.1
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 145.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 143.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 142.9
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 142.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 139.6
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 137.9
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 135.6
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 135.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 134.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 133.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 133.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 131.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 129.9
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 128.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 126.6
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 126.3
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 124.4
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 124.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 123.1
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 123.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 121.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 120.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 120.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 120.2
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 120.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 111.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 111.3
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 110.2
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 109.6
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 107.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 72.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 71.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 65.0
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 338.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 338.5
FF:10158-103A5 76 years, female 338.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 62.3
Pig sample Sample description nTPM
Midbrain
nTPM: 62.3
Samples: 4

Max nTPM: 111.5
Min nTPM: 29.7
Sample A Female 111.5
Sample B Female 65.5
Sample C Male 42.5
Sample D Male 29.7
Periaqueductal gray
nTPM: 46.3
Samples: 3

Max nTPM: 55.8
Min nTPM: 41.1
Sample B Female 55.8
Sample C Male 41.1
Sample D Male 42.0
Substantia nigra
nTPM: 57.0
Samples: 4

Max nTPM: 62.0
Min nTPM: 50.1
Sample A Female 60.4
Sample B Female 55.5
Sample C Male 50.1
Sample D Male 62.0
Superior colliculi
nTPM: 45.0
Samples: 4

Max nTPM: 50.5
Min nTPM: 35.3
Sample A Female 44.3
Sample B Female 35.3
Sample C Male 50.5
Sample D Male 49.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 48.4
Mouse sample Sample description nTPM
Midbrain
nTPM: 48.4
Samples: 4

Max nTPM: 53.3
Min nTPM: 43.6
Sample A Male 50.3
Sample B Male 43.6
Sample C Female 46.4
Sample D Female 53.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.4
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.4
112650769 Antisense, RP_071128_04_A08, Mouse strain C57BL/6J (56 days, male) 3.7
2302 Antisense, RP_040604_02_B07, Mouse strain C57BL/6J (56 days, male) 1.2

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