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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:106.3 nTPM
HPA:106.3 nTPM
GTEx:103.6 nTPM
FANTOM5:73.0 Scaled Tags Per Million
Pig:226.9 nTPM
Mouse:126.2 nTPM
Allen mouse:2.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 106.3
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 89.7
2586 Male, age 75, left hemisphere 145.8
2019 Male, age 18, unknown 102.6
2666 Male, age 74, left hemisphere 91.1
2828 Female, age 72, unknown 87.0
2219 Male, age 76, both hemispheres 85.6
2411 Female, age 72, unknown 79.4
1870 Female, age 42, unknown 77.6
1827 Male, age 72, unknown 77.3
1830 Male, age 51, unknown 76.4
1833 Male, age 53, unknown 73.8
Dorsal raphe nucleus
nTPM: 79.3
2047 Male, age 72, unknown 92.3
2750 Male, age 76, both hemispheres 90.6
1828 Male, age 53, unknown 76.2
2016 Female, age 72, unknown 69.2
2298 Female, age 72, unknown 68.1
Inferior colliculus
nTPM: 71.1
1890 Male, age 53, unknown 77.7
1848 Female, age 42, unknown 73.7
2097 Female, age 72, unknown 68.7
2849 Male, age 72, unknown 64.4
Median raphe nucleus
nTPM: 89.4
2220 Male, age 76, midline 89.4
Pedunculopontine tegmental nucleus
nTPM: 74.2
2334 Male, age 80, both hemispheres 82.9
1921 Female, age 85, both hemispheres 76.8
2338 Male, age 61, both hemispheres 63.0
Periaquaductal grey, anterior
nTPM: 82.6
1795 Male, age 51, unknown 83.6
1947 Male, age 18, unknown 83.6
2502 Female, age 75, unknown 80.6
Periaquaductal grey, dorsal
nTPM: 63.6
1831 Male, age 72, unknown 67.7
1840 Male, age 53, unknown 65.4
2464 Female, age 72, unknown 61.1
2850 Male, age 76, both hemispheres 60.2
Periaquaductal grey, lateral
nTPM: 57.0
2053 Male, age 18, unknown 60.6
2140 Male, age 76, both hemispheres 55.4
2272 Male, age 74, both hemispheres 55.0
Pretectal area
nTPM: 81.6
2007 Male, age 72, unknown 106.7
1817 Female, age 42, unknown 101.9
1944 Female, age 72, unknown 95.4
1815 Male, age 53, unknown 95.2
1816 Male, age 51, unknown 91.4
2407 Male, age 75, both hemispheres 87.7
2667 Female, age 75, unknown 76.7
2825 Male, age 18, unknown 66.4
2224 Female, age 72, unknown 62.5
2316 Male, age 76, right hemisphere 58.1
2273 Male, age 74, both hemispheres 56.0
Red nucleus
nTPM: 88.7
2584 Male, age 75, left hemisphere 123.3
2785 Male, age 18, unknown 101.7
2588 Male, age 74, left hemisphere 100.1
1821 Female, age 72, unknown 91.7
1904 Male, age 53, unknown 87.2
1865 Male, age 51, unknown 86.1
1954 Female, age 42, unknown 85.2
2769 Male, age 72, unknown 82.7
2503 Female, age 72, unknown 82.4
2227 Male, age 72, unknown 80.5
2725 Female, age 75, unknown 77.3
2823 Male, age 76, right hemisphere 66.8
Substantia nigra
nTPM: 106.3
2583 Male, age 75, right hemisphere 128.8
1851 Male, age 51, unknown 119.5
2665 Male, age 74, both hemispheres 119.4
1916 Female, age 42, unknown 119.0
1889 Female, age 72, unknown 101.1
2590 Female, age 75, unknown 100.8
1941 Male, age 53, unknown 97.7
2241 Male, age 72, unknown 94.8
2409 Female, age 72, unknown 91.0
2699 Male, age 18, unknown 90.6
Superior colliculus
nTPM: 79.4
2664 Male, age 75, both hemispheres 106.8
2668 Female, age 75, unknown 97.9
1796 Male, age 53, unknown 82.9
2087 Female, age 72, unknown 82.8
1995 Male, age 72, unknown 74.1
2261 Male, age 18, unknown 74.1
2587 Male, age 74, left hemisphere 73.8
1839 Male, age 51, unknown 71.2
1913 Female, age 42, unknown 67.3
1895 Male, age 76, right hemisphere 63.5
Ventral tegmental area
nTPM: 95.5
2223 Female, age 72, unknown 104.8
2410 Female, age 72, unknown 98.5
2218 Male, age 76, both hemispheres 96.7
1915 Female, age 42, unknown 93.5
1942 Male, age 51, unknown 92.9
2021 Male, age 53, unknown 86.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 103.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 103.6
Samples: 139

Max nTPM: 172.4
Min nTPM: 54.2
Std nTPM: 19.7
Median nTPM: 101.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 172.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 167.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 156.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 156.1
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 148.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 142.4
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 133.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 130.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 130.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 130.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 129.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 126.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 126.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 124.6
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 124.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 124.2
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 122.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 121.8
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 121.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 121.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 121.4
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 121.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 121.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 120.9
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 120.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 119.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 119.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 119.6
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 118.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 118.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 118.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 117.9
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 117.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 117.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 117.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 116.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 116.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 115.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 115.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 115.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 115.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 114.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 114.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 112.9
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 112.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 112.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 112.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 112.6
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 112.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 111.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 109.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 109.3
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 108.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 107.6
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 106.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 106.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 106.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 106.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 105.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 105.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 105.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 104.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 104.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 104.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 103.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 103.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 103.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 102.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 102.1
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 101.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 101.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 100.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 100.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 100.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 99.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 98.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 98.5
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 97.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 97.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 97.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 97.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 96.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 96.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 96.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 95.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 95.5
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 95.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 95.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 95.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 94.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 94.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 94.6
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 94.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 94.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 93.6
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 93.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 93.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 92.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 92.1
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 90.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 90.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 90.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 90.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 89.3
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 88.9
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 88.7
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 88.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 88.1
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 87.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 87.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 86.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 86.6
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 85.9
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 85.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 85.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 85.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 85.3
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 85.0
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 83.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 83.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 83.5
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 83.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 83.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 82.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 82.3
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 82.1
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 80.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 80.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 80.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 79.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 79.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 78.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 76.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 76.1
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 71.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 68.3
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 64.6
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 58.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 54.2
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 73.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 73.0
FF:10158-103A5 76 years, female 73.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 226.9
Pig sample Sample description nTPM
Midbrain
nTPM: 226.8
Samples: 4

Max nTPM: 281.3
Min nTPM: 187.3
Sample A Female 233.2
Sample B Female 187.3
Sample C Male 281.3
Sample D Male 205.5
Periaqueductal gray
nTPM: 145.1
Samples: 3

Max nTPM: 156.9
Min nTPM: 129.3
Sample B Female 156.9
Sample C Male 149.1
Sample D Male 129.3
Substantia nigra
nTPM: 210.6
Samples: 4

Max nTPM: 249.1
Min nTPM: 159.6
Sample A Female 249.1
Sample B Female 159.6
Sample C Male 247.2
Sample D Male 186.6
Superior colliculi
nTPM: 199.2
Samples: 4

Max nTPM: 227.5
Min nTPM: 138.1
Sample A Female 215.9
Sample B Female 138.1
Sample C Male 227.5
Sample D Male 215.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 126.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 126.2
Samples: 4

Max nTPM: 131.9
Min nTPM: 123.2
Sample A Male 125.9
Sample B Male 123.2
Sample C Female 123.7
Sample D Female 131.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.9
71764320 Antisense, RP_050921_03_E08, Mouse strain C57BL/6J (56 days, male) 2.9

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