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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:156.5 nTPM
HPA:156.5 nTPM
GTEx:224.3 nTPM
FANTOM5:476.9 Scaled Tags Per Million
Pig:150.7 nTPM
Mouse:75.9 nTPM
Allen mouse:4.3 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 156.5
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 130.1
2219 Male, age 76, both hemispheres 161.5
1830 Male, age 51, unknown 141.0
2586 Male, age 75, left hemisphere 141.0
2411 Female, age 72, unknown 140.9
1833 Male, age 53, unknown 133.4
1870 Female, age 42, unknown 128.9
2019 Male, age 18, unknown 127.7
2828 Female, age 72, unknown 121.8
1827 Male, age 72, unknown 103.8
2666 Male, age 74, left hemisphere 101.1
Dorsal raphe nucleus
nTPM: 104.0
2750 Male, age 76, both hemispheres 139.1
2016 Female, age 72, unknown 111.6
1828 Male, age 53, unknown 105.6
2047 Male, age 72, unknown 86.5
2298 Female, age 72, unknown 77.3
Inferior colliculus
nTPM: 103.4
1890 Male, age 53, unknown 116.3
1848 Female, age 42, unknown 100.5
2849 Male, age 72, unknown 99.5
2097 Female, age 72, unknown 97.5
Median raphe nucleus
nTPM: 75.9
2220 Male, age 76, midline 75.9
Pedunculopontine tegmental nucleus
nTPM: 104.1
2334 Male, age 80, both hemispheres 113.8
2338 Male, age 61, both hemispheres 100.7
1921 Female, age 85, both hemispheres 97.7
Periaquaductal grey, anterior
nTPM: 97.4
2502 Female, age 75, unknown 111.2
1947 Male, age 18, unknown 92.6
1795 Male, age 51, unknown 88.5
Periaquaductal grey, dorsal
nTPM: 82.6
2464 Female, age 72, unknown 108.8
1831 Male, age 72, unknown 82.9
1840 Male, age 53, unknown 77.0
2850 Male, age 76, both hemispheres 61.5
Periaquaductal grey, lateral
nTPM: 85.2
2053 Male, age 18, unknown 93.6
2272 Male, age 74, both hemispheres 93.4
2140 Male, age 76, both hemispheres 68.4
Pretectal area
nTPM: 100.4
2316 Male, age 76, right hemisphere 134.0
1815 Male, age 53, unknown 122.3
1817 Female, age 42, unknown 112.4
2007 Male, age 72, unknown 110.5
2407 Male, age 75, both hemispheres 108.2
2667 Female, age 75, unknown 96.1
2825 Male, age 18, unknown 96.1
2224 Female, age 72, unknown 85.6
2273 Male, age 74, both hemispheres 81.4
1816 Male, age 51, unknown 80.1
1944 Female, age 72, unknown 77.2
Red nucleus
nTPM: 156.5
2769 Male, age 72, unknown 180.5
2227 Male, age 72, unknown 180.0
2503 Female, age 72, unknown 179.7
1904 Male, age 53, unknown 176.4
1865 Male, age 51, unknown 168.7
2823 Male, age 76, right hemisphere 165.4
2588 Male, age 74, left hemisphere 156.1
1821 Female, age 72, unknown 155.8
2785 Male, age 18, unknown 150.2
1954 Female, age 42, unknown 144.2
2584 Male, age 75, left hemisphere 117.6
2725 Female, age 75, unknown 103.2
Substantia nigra
nTPM: 106.9
2699 Male, age 18, unknown 138.2
1851 Male, age 51, unknown 121.5
2583 Male, age 75, right hemisphere 119.0
2665 Male, age 74, both hemispheres 114.7
2409 Female, age 72, unknown 111.3
1889 Female, age 72, unknown 107.1
2590 Female, age 75, unknown 103.8
1916 Female, age 42, unknown 90.2
1941 Male, age 53, unknown 82.3
2241 Male, age 72, unknown 81.2
Superior colliculus
nTPM: 119.1
2668 Female, age 75, unknown 155.3
1995 Male, age 72, unknown 149.8
1895 Male, age 76, right hemisphere 140.7
1913 Female, age 42, unknown 132.2
1839 Male, age 51, unknown 119.2
2587 Male, age 74, left hemisphere 113.3
2664 Male, age 75, both hemispheres 112.8
1796 Male, age 53, unknown 97.6
2261 Male, age 18, unknown 87.6
2087 Female, age 72, unknown 83.1
Ventral tegmental area
nTPM: 106.8
2410 Female, age 72, unknown 124.1
2223 Female, age 72, unknown 119.1
1915 Female, age 42, unknown 105.5
1942 Male, age 51, unknown 103.4
2021 Male, age 53, unknown 99.3
2218 Male, age 76, both hemispheres 89.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 224.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 224.3
Samples: 139

Max nTPM: 496.0
Min nTPM: 42.9
Std nTPM: 88.3
Median nTPM: 207.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 496.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 437.8
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 435.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 423.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 412.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 397.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 392.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 385.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 370.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 359.7
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 356.5
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 355.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 352.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 350.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 343.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 342.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 341.2
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 341.0
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 340.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 336.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 332.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 321.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 320.6
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 315.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 309.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 308.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 308.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 306.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 306.0
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 305.7
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 303.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 301.4
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 299.1
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 298.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 292.5
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 281.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 277.5
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 272.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 270.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 270.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 262.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 262.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 261.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 261.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 257.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 252.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 249.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 245.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 244.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 243.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 239.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 238.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 238.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 236.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 236.5
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 233.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 221.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 220.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 218.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 217.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 214.9
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 214.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 214.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 213.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 213.4
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 212.9
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 211.6
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 209.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 209.4
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 207.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 205.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 204.6
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 204.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 202.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 201.7
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 200.4
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 196.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 194.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 194.5
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 194.3
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 192.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 192.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 191.9
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 190.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 190.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 187.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 186.8
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 186.3
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 184.5
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 184.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 183.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 181.7
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 177.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 174.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 174.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 172.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 172.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 171.8
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 171.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 171.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 167.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 166.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 166.0
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 165.6
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 164.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 163.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 162.2
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 156.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 155.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 154.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 151.9
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 151.1
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 149.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 146.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 145.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 145.3
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 143.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 143.2
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 141.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 140.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 136.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 134.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 127.4
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 122.6
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 116.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 113.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 111.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 110.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 105.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 103.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 99.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 94.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 94.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 92.6
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 91.5
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 80.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 77.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 74.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 42.9
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 476.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 476.9
FF:10158-103A5 76 years, female 476.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 150.7
Pig sample Sample description nTPM
Midbrain
nTPM: 148.3
Samples: 4

Max nTPM: 209.6
Min nTPM: 108.3
Sample A Female 209.6
Sample B Female 162.1
Sample C Male 108.3
Sample D Male 113.1
Periaqueductal gray
nTPM: 111.2
Samples: 3

Max nTPM: 140.2
Min nTPM: 94.2
Sample B Female 140.2
Sample C Male 94.2
Sample D Male 99.3
Substantia nigra
nTPM: 150.7
Samples: 4

Max nTPM: 198.9
Min nTPM: 107.2
Sample A Female 180.0
Sample B Female 107.2
Sample C Male 116.6
Sample D Male 198.9
Superior colliculi
nTPM: 128.2
Samples: 4

Max nTPM: 168.8
Min nTPM: 70.3
Sample A Female 168.8
Sample B Female 70.3
Sample C Male 130.6
Sample D Male 143.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 75.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 75.9
Samples: 4

Max nTPM: 85.3
Min nTPM: 65.8
Sample A Male 85.3
Sample B Male 65.8
Sample C Female 69.3
Sample D Female 83.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 4.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 4.3
70437828 Antisense, RP_050614_03_A03, Mouse strain C57BL/6J (56 days, male) 4.3

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