We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
IFITM2
SECTIONS
  • TISSUE
  • BRAIN
  • SINGLE CELL TYPE
  • TISSUE CELL TYPE
  • PATHOLOGY
  • DISEASE
  • IMMUNE CELL
  • BLOOD PROTEIN
  • SUBCELLULAR
  • CELL LINE
  • STRUCTURE
  • METABOLIC
ABOUT
  • INTRODUCTION
  • HISTORY
  • ORGANIZATION
  • PUBLICATIONS
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • ACKNOWLEDGMENTS
  • CONTACT
NEWS
  • NEWS ARTICLES
  • PRESS ROOM
LEARN
  • DICTIONARY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
  • METHODS
  • EDUCATIONAL VIDEOS
DATA
  • DOWNLOADABLE DATA
  • PUBLICATION DATA
  • RELEASE HISTORY
  • SARS-COV-2
HELP
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • HELP & FAQ
  • PRIVACY STATEMENT
  • LICENCE & CITATION
Fields ยป
Search result

 
Field
All
Term
Gene name
Class
Blood group antigen proteins
Subclass
 
Class
 
Keyword
Chromosome
External id
Tissue
 
Cell type
 
Expression
Patient ID
Tissue
Category
Cluster
Reliability
Brain region
Category
Brain region
Category
Brain region
Category
Reliability
Cell type
Category
Cluster
Tissue
 
Cell type
Enrichment
Cancer
Prognosis
Cancer
Category
Cell type
Category
Cell lineage
Category
Cluster
Annotation
Disease
Location
Searches
Location
Cell line
Type
Phase
Reliability
Cancer type
Category
Cluster
Pathway
Category
Score
Score
Score
Validation
Validation
Validation
Validation
Antibodies
Yes
Protein structure
In atlas
Column
Gene


                        • SPECIFICITY
                        • DISTRIBUTION
                        • EXPRESSION
                        • SPECIFICITY
                        • DISTRIBUTION
                        • EXPRESSION
                        • SPECIFICITY
                        • DISTRIBUTION
                        • EXPRESSION
                        • SPECIFICITY
                        • DISTRIBUTION
                        • EXPRESSION
                        • SPECIFICITY
                        • DISTRIBUTION
                        • EXPRESSION
                          • SPECIFICITY
                          • DISTRIBUTION
                          • EXPRESSION
                          • SPECIFICITY
                          • DISTRIBUTION
                          • EXPRESSION
                          • SPECIFICITY
                          • DISTRIBUTION
                          • EXPRESSION
                          • RELIABILITY
                          • SUBCELLULAR VARIATION
                          • MULTILOCALIZATION
                          • OTHER
                          • SPECIFICITY
                          • DISTRIBUTION
                          • EXPRESSION
                          • Check all
                          • Uncheck all
                                • SUMMARY

                                • TISSUE

                                • BRAIN

                                • SINGLE CELL

                                • TISSUE CELL

                                • PATHOLOGY

                                • DISEASE

                                • IMMUNE

                                • BLOOD

                                • SUBCELL

                                • CELL LINE

                                • STRUCTURE

                                • METABOLIC

                                • IFITM2
                                IMMUNE CELL CELL LINEAGES Show tissue menu
                                B-CELLS DENDRITIC CELLS GRANULOCYTES MONOCYTES NK-CELLS PROGENITORS T-CELLS TOTAL PBMC
                                Immune cell proteome
                                GENERAL INFORMATIONi

                                General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

                                Gene namei

                                Official gene symbol, which is typically a short form of the gene name, according to HGNC.

                                IFITM2
                                Gene descriptioni

                                Full gene name according to HGNC.

                                Interferon induced transmembrane protein 2
                                Predicted locationi

                                All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

                                • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

                                • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

                                The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

                                Read more
                                Membrane
                                IMMUNE CELL SECTION SUMMARY
                                Immune cell type expression clusteri

                                The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                Read more
                                Neutrophils - Cellular senescence (mainly)
                                Immune cell type specificityi

                                The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

                                Read more
                                Immune cell enriched (neutrophil)
                                Tau specificity scorei

                                Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.

                                Read more
                                0.33
                                Immune cell type distributioni

                                The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.

                                Read more
                                Detected in all
                                Immune cell lineage specificityi

                                The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells.

                                Read more
                                Lineage enriched (granulocytes)
                                Immune cell lineage distributioni

                                The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                Read more
                                Detected in all
                                IMMUNE CELL TYPE EXPRESSION (RNA)i

                                Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.

                                HPA dataseti

                                The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC).

                                Read more
                                Lineage
                                Expression
                                Alphabetical
                                Immune cell type specificity: Immune cell enriched (neutrophil)
                                BasophilEosinophilNeutrophilClassical monocyteNon-classical monocyteIntermediate monocyteT-regGdT-cellMAIT T-cellMemory CD4 T-cellNaive CD4 T-cellMemory CD8 T-cellNaive CD8 T-cellMemory B-cellNaive B-cellPlasmacytoid DCMyeloid DCNK-cellTotal PBMC05,00010,00015,00020,00025,000nTPMGranulocytesMonocytesT-cellsB-cellsDendritic cellsNK-cellsTotal PBMC
                                Monaco dataseti

                                The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al.

                                Read more
                                Lineage
                                Expression
                                Alphabetical
                                BasophilNeutrophilClassical monocyteNon-classical monocyteIntermediate monocyteT-regMAIT T-cellNaive CD4 T-cellVd2 gdTCRMemory CD4 T-cell Th1/Th17Memory CD4 T-cell Th17Memory CD4 T-cell Th2Non-Vd2 gdTCRMemory CD4 T-cell Th1Memory CD4 T-cell TFHTerminal effector memory CD4 T-cellNaive CD8 T-cellCentral memory CD8 T-cellEffector memory CD8 T-cellTerminal effector memory CD8 T-cellNaive B-cellNon-switched memory B-cellPlasmablastSwitched memory B-cellExhausted memory B-cellPlasmacytoid DCMyeloid DCNK-cellProgenitor cellTotal PBMC05,00010,00015,00020,00025,000nTPMGranulocytesMonocytesT-cellsB-cellsDendritic cellsNK-cellsProgenitorsTotal PBMC
                                Schmiedel dataseti

                                Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset.

                                Read more
                                Lineage
                                Expression
                                Alphabetical
                                Classical monocyteNon-classical monocyteNaive CD4 T-cellMemory CD4 T-cell TFHMemory CD4 T-cell Th1Memory CD4 T-cell Th1/Th17Memory CD4 T-cell Th17Memory CD4 T-cell Th2Memory T-regNaive CD4 T-cell activatedNaive CD8 T-cell activatedNaive T-regNaive CD8 T-cellNaive B-cellNK-cell02004006008001,0001,200TPMMonocytesT-cellsB-cellsNK-cells
                                EXPRESSION CLUSTERING & CORRELATIONi

                                The RNA data was used to cluster genes according to their expression across samples. The resulting clusters have been manually annotated to describe common features in terms of function and specificity. The annotation of the cluster is displayed together with a confidence score of the gene's assignment to the cluster. The confidence is calculated as the fraction of times the gene was assigned to this cluster in repeated calculations and is reported between 0 to 1, where 1 is the highest possible confidence. The clustering results are shown in a UMAP, where the cluster this gene was assigned to is highlighted as a colored area in which most of the cluster genes reside. A table shows the 15 most similar genes in terms of expression profile.

                                Read more
                                IFITM2 is part of cluster 50 Neutrophils - Cellular senescence with confidencei

                                Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

                                Read more
                                0.98
                                129 genes in cluster
                                Go to interactive expression cluster page
                                15 nearest neighbours based on immune cell RNA expression
                                Neighbouri

                                Gene name according to HGNC.

                                Descriptioni

                                Gene description according to HGNC.

                                Correlationi

                                Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

                                Read more
                                Clusteri

                                ID of the expression cluster of the neighboring gene.

                                Read more
                                TNFRSF10C TNF receptor superfamily member 10c 0.9631 50
                                SEC14L1 SEC14 like lipid binding 1 0.9546 50
                                DRC1 Dynein regulatory complex subunit 1 0.9537 50
                                NECAB2 N-terminal EF-hand calcium binding protein 2 0.9524 50
                                CXCL8 C-X-C motif chemokine ligand 8 0.9475 50
                                IL1R2 Interleukin 1 receptor type 2 0.9422 50
                                USP10 Ubiquitin specific peptidase 10 0.9355 50
                                INKA2 Inka box actin regulator 2 0.9346 50
                                PTGS2 Prostaglandin-endoperoxide synthase 2 0.9226 50
                                CXCL1 C-X-C motif chemokine ligand 1 0.9123 9
                                STEAP4 STEAP4 metalloreductase 0.9088 50
                                H2BC4 H2B clustered histone 4 0.9048 50
                                CHI3L1 Chitinase 3 like 1 0.9043 9
                                CXCL6 C-X-C motif chemokine ligand 6 0.8990 50
                                OR11G2 Olfactory receptor family 11 subfamily G member 2 0.8968 50

                                Contact

                                • NEWS ARTICLES
                                • PRESS ROOM
                                • contact@proteinatlas.org

                                The Project

                                • INTRODUCTION
                                • ORGANIZATION
                                • PUBLICATIONS

                                The Human Protein Atlas

                                • DOWNLOADABLE DATA
                                • LICENCE & CITATION
                                • HELP & FAQ
                                The Human Protein Atlas project is funded
                                by the Knut & Alice Wallenberg Foundation.