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PATHOLOGY PANCREATIC CANCER Show tissue menu
BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER LIVER CANCER LUNG CANCER LYMPHOMA
MELANOMA OVARIAN CANCER PANCREATIC CANCER PROSTATE CANCER RENAL CANCER SKIN CANCER STOMACH CANCER TESTIS CANCER THYROID CANCER UROTHELIAL CANCER
ANTIBODIES
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Pancreatic cancer
Human pathology
Pancreatic cancer
PANCREATIC CANCER - Interactive survival scatter ploti

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisi

Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.

Read more
RPS4X is not prognostic in pancreatic cancer


Stage:

Survival analysis
Current cut offi

Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.

:
Best expression cut offi

Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .

When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.

Read more
: 395.41
Median expressioni

Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.

Read more
: N/A
Median follow up timei

Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.

: N/A
P scorei

Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.

N/A
5-year survival highi

5-year survival for patients with higher expression than the expression cutoff.

For melanoma and glioma, 3-year survival is shown.

N/A
5-year survival lowi

5-year survival for patients with lower expression than the expression cutoff.

For melanoma and glioma, 3-year survival is shown.

N/A
TCGA RNA samplesi

RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.

Average FPKM 394.3
Number of samples 176
Samples
Sample Description FPKM
TCGA-HV-A7OP-01A 72 years, male, asian, stage:iib, alive, 978 days 1153.7
TCGA-IB-7889-01A 86 years, female, white, stage:iib, dead, 481 days 922.2
TCGA-2J-AABI-01A 55 years, female, white, stage:iia, alive, 969 days 858.4
TCGA-Z5-AAPL-01A 74 years, female, white, stage:iia, alive, 467 days 768.8
TCGA-IB-7644-01A 65 years, female, white, stage:iv, dead, 394 days 755.5
TCGA-3A-A9IN-01A 62 years, female, white, stage:ib, alive, 2084 days 752.2
TCGA-IB-7886-01A 80 years, male, white, stage:iib, dead, 123 days 737.9
TCGA-S4-A8RO-01A 75 years, female, white, stage:iib, alive, 525 days 714.8
TCGA-US-A77J-01A 81 years, female, white, stage:iib, dead, 568 days 700.2
TCGA-RL-AAAS-01A 60 years, female, white, stage:ib, alive, 9 days 699.8
TCGA-LB-A8F3-01A 64 years, female, black or african american, stage:iia, alive, 379 days 678.4
TCGA-FB-AAQ3-01A 65 years, female, white, stage:iib, dead, 31 days 662.7
TCGA-IB-A6UG-01A 65 years, male, white, stage:iib, dead, 41 days 643.8
TCGA-US-A779-01A 54 years, female, white, stage:iib, dead, 511 days 621.1
TCGA-HZ-A49H-01A 68 years, female, white, stage:iib, alive, 491 days 614.1
TCGA-FB-AAPU-01A 41 years, female, asian, stage:iia, dead, 381 days 608.9
TCGA-IB-7887-01A 62 years, female, white, stage:iib, dead, 110 days 595.3
TCGA-IB-7649-01A 73 years, female, stage:iib, dead, 467 days 586.7
TCGA-IB-A7LX-01A 57 years, male, white, stage:iib, dead, 250 days 579.5
TCGA-FB-A78T-01A 71 years, female, white, stage:iib, dead, 375 days 579.1
TCGA-Q3-AA2A-01A 64 years, female, white, stage:ib, alive, 95 days 574.9
TCGA-3A-A9IL-01A 39 years, female, white, stage:i, alive, 2741 days 572.3
TCGA-IB-7888-01A 66 years, female, black or african american, stage:iia, dead, 1332 days 555.2
TCGA-XD-AAUH-01A 57 years, female, white, stage:iib, alive, 395 days 553.9
TCGA-YY-A8LH-01A 61 years, female, white, stage:iib, alive, 2016 days 553.2
TCGA-Q3-A5QY-01A 58 years, male, white, stage:iib, alive, 416 days 547.9
TCGA-HZ-8001-01A 69 years, male, white, stage:iii, alive, 706 days 538.2
TCGA-2J-AABK-01A 71 years, male, white, stage:iib, alive, 484 days 525.7
TCGA-XD-AAUG-01A 66 years, female, white, stage:iv, alive, 420 days 516.8
TCGA-IB-A5ST-01A 64 years, female, white, stage:iib, alive, 635 days 516.3
TCGA-XD-AAUI-01A 50 years, female, white, stage:iib, dead, 366 days 513.6
TCGA-HZ-A77O-01A 77 years, female, white, stage:iib, dead, 160 days 509.5
TCGA-FB-AAQ6-01A 85 years, male, white, stage:ia, dead, 244 days 500.5
TCGA-H6-8124-01A 56 years, female, white, stage:iib, alive, 392 days 497.0
TCGA-3A-A9IJ-01A 65 years, male, white, stage:ib, alive, 1854 days 490.2
TCGA-F2-A44G-01A 79 years, female, white, stage:iib, dead, 233 days 489.9
TCGA-IB-AAUW-01A 63 years, female, white, stage:iib, dead, 230 days 485.1
TCGA-3A-A9I5-01A 58 years, male, white, alive, 1794 days 480.9
TCGA-HZ-7289-01A 77 years, male, white, stage:iib, dead, 661 days 480.0
TCGA-FB-AAPZ-01A 54 years, male, white, stage:iib, alive, 716 days 478.4
TCGA-HZ-8637-01A 76 years, female, white, stage:iib, dead, 517 days 473.8
TCGA-XN-A8T5-01A 53 years, female, white, stage:ib, alive, 720 days 467.3
TCGA-US-A774-01A 76 years, female, white, stage:iib, dead, 695 days 465.9
TCGA-FB-A5VM-01A 74 years, male, white, stage:ib, dead, 498 days 463.3
TCGA-2J-AABV-01A 74 years, male, white, stage:iib, dead, 652 days 460.3
TCGA-FB-AAQ2-01A 81 years, female, white, stage:iib, dead, 153 days 457.1
TCGA-2J-AABP-01A 58 years, female, white, stage:iib, alive, 463 days 439.0
TCGA-FB-AAPS-01A 62 years, female, white, stage:iib, alive, 228 days 435.0
TCGA-FB-A4P5-01A 69 years, female, white, stage:iib, dead, 179 days 429.8
TCGA-2J-AAB9-01A 71 years, female, white, stage:iib, dead, 627 days 426.0
TCGA-3A-A9IR-01A 64 years, female, white, stage:ib, alive, 1542 days 422.5
TCGA-2L-AAQM-01A 52 years, male, white, stage:iib, alive, 1383 days 421.3
TCGA-OE-A75W-01A 75 years, male, white, stage:iia, dead, 267 days 420.8
TCGA-IB-A7M4-01A 81 years, male, white, stage:iib, alive, 483 days 415.5
TCGA-HZ-A8P1-01A 81 years, male, white, stage:ib, alive, 7 days 414.0
TCGA-IB-7645-01A 44 years, female, stage:iib, dead, 1502 days 409.1
TCGA-HZ-7919-01A 52 years, female, white, stage:iib, dead, 593 days 407.4
TCGA-PZ-A5RE-01A 44 years, female, white, stage:iib, dead, 470 days 405.8
TCGA-HZ-7924-01A 60 years, female, white, stage:iia, alive, 840 days 400.6
TCGA-IB-7891-01A 49 years, female, white, stage:iib, dead, 913 days 400.2
TCGA-2J-AABR-01A 60 years, female, white, stage:iia, alive, 438 days 398.2
TCGA-F2-A8YN-01A 76 years, male, white, stage:iia, alive, 517 days 397.0
TCGA-H6-A45N-01A 88 years, female, white, stage:iib, dead, 421 days 393.8
TCGA-IB-AAUP-01A 68 years, male, white, stage:iib, alive, 431 days 391.8
TCGA-3A-A9IC-01A 61 years, female, white, stage:iib, dead, 738 days 391.7
TCGA-3A-A9IB-01A 69 years, female, white, stage:iib, dead, 224 days 390.2
TCGA-2L-AAQJ-01A 49 years, female, white, stage:iii, dead, 394 days 388.9
TCGA-HZ-A9TJ-01A 70 years, male, white, stage:iv, alive, 603 days 388.6
TCGA-IB-A5SQ-01A 56 years, female, white, stage:ib, dead, 219 days 388.5
TCGA-IB-AAUR-01A 67 years, male, white, stage:iib, alive, 338 days 387.6
TCGA-IB-A5SP-01A 77 years, male, white, stage:iia, alive, 482 days 385.9
TCGA-LB-A9Q5-01A 63 years, female, white, stage:iib, dead, 313 days 384.7
TCGA-S4-A8RP-01A 77 years, female, white, stage:iib, dead, 702 days 383.0
TCGA-HZ-7920-01A 71 years, male, white, stage:ib, dead, 236 days 382.4
TCGA-2J-AABT-01A 72 years, female, white, stage:iib, alive, 319 days 380.4
TCGA-FB-AAQ1-01A 49 years, male, white, stage:iib, dead, 123 days 380.3
TCGA-2L-AAQL-01A 82 years, male, white, stage:iib, dead, 292 days 379.7
TCGA-US-A776-01A 61 years, male, white, stage:iia, alive, 1216 days 379.6
TCGA-IB-AAUS-01A 84 years, female, white, stage:iib, alive, 225 days 378.0
TCGA-IB-AAUO-01A 64 years, female, white, stage:iib, dead, 239 days 376.6
TCGA-2L-AAQE-01A 56 years, male, white, stage:iib, dead, 684 days 376.4
TCGA-IB-8126-01A 80 years, female, white, stage:iii, alive, 462 days 376.3
TCGA-FB-AAPP-01A 71 years, male, white, stage:iib, dead, 485 days 372.6
TCGA-IB-7897-01A 54 years, female, white, stage:iib, dead, 486 days 365.4
TCGA-FB-AAQ0-01A 68 years, male, white, stage:iia, dead, 473 days 364.6
TCGA-HZ-A49G-01A 58 years, female, white, stage:iib, alive, 660 days 363.6
TCGA-L1-A7W4-01A 48 years, female, white, stage:iib, dead, 278 days 359.4
TCGA-HV-A7OL-01A 70 years, male, asian, stage:iia, alive, 252 days 358.4
TCGA-2L-AAQA-01A 76 years, male, white, stage:iib, dead, 143 days 355.4
TCGA-YH-A8SY-01A 73 years, female, white, alive, 388 days 353.4
TCGA-HZ-8317-01A 69 years, female, white, stage:iib, dead, 378 days 353.2
TCGA-HZ-8315-01A 54 years, female, white, stage:iia, dead, 299 days 352.3
TCGA-IB-7652-01A 49 years, female, asian, stage:iib, alive, 1116 days 352.0
TCGA-HV-A5A5-01A 61 years, female, asian, stage:iib, alive, 289 days 348.9
TCGA-IB-AAUN-01A 74 years, female, white, stage:ib, dead, 144 days 345.4
TCGA-FB-AAPY-01A 71 years, male, white, stage:iib, dead, 1059 days 344.0
TCGA-HZ-8636-01A 58 years, female, white, stage:iv, dead, 545 days 343.5
TCGA-3A-A9IH-01A 66 years, female, white, stage:ia, alive, 1021 days 340.8
TCGA-HZ-A77Q-01A 55 years, female, white, stage:iib, alive, 33 days 340.8
TCGA-RB-A7B8-01A 81 years, female, white, stage:iib, dead, 466 days 339.2
TCGA-IB-A6UF-01A 63 years, male, white, stage:iib, alive, 666 days 337.5
TCGA-HV-A5A4-01A 72 years, female, asian, stage:iia, alive, 232 days 337.4
TCGA-HZ-8638-01A 84 years, female, white, stage:ia, dead, 151 days 337.0
TCGA-HV-A5A6-01A 65 years, female, asian, stage:iib, dead, 2036 days 336.6
TCGA-HZ-7922-01A 61 years, female, white, stage:iib, alive, 4 days 335.9
TCGA-2J-AAB1-01A 65 years, male, white, stage:iib, dead, 66 days 334.6
TCGA-3A-A9IV-01A 59 years, female, white, stage:ib, alive, 1103 days 334.1
TCGA-3E-AAAZ-01A 71 years, male, white, stage:iia, dead, 2182 days 333.4
TCGA-F2-A44H-01A 65 years, male, white, stage:iia, alive, 586 days 332.5
TCGA-IB-7885-01A 78 years, female, white, stage:iib, alive, 1257 days 331.5
TCGA-IB-AAUM-01A 76 years, male, white, stage:iib, alive, 8 days 329.0
TCGA-IB-8127-01A 59 years, male, white, stage:iib, alive, 522 days 324.3
TCGA-F2-6879-01A 57 years, male, white, stage:iib, dead, 334 days 323.1
TCGA-F2-A7TX-01A 77 years, male, white, stage:iib, dead, 95 days 322.5
TCGA-LB-A7SX-01A 74 years, female, black or african american, stage:iib, dead, 393 days 322.1
TCGA-2J-AABA-01A 55 years, male, white, stage:iib, dead, 607 days 317.1
TCGA-HZ-8519-01A 73 years, male, white, stage:ia, alive, 454 days 316.0
TCGA-IB-AAUV-01A 49 years, male, white, stage:iib, alive, 404 days 315.4
TCGA-3A-A9IX-01A 40 years, male, white, stage:ia, alive, 1037 days 314.7
TCGA-IB-7651-01A 64 years, female, white, stage:iib, dead, 603 days 314.1
TCGA-3A-A9IO-01A 56 years, male, white, alive, 1942 days 313.2
TCGA-FB-AAPQ-01A 65 years, male, white, stage:iib, dead, 1130 days 312.2
TCGA-2L-AAQI-01A 66 years, male, white, stage:iib, dead, 103 days 309.8
TCGA-HV-AA8X-01A 75 years, female, asian, stage:iib, dead, 532 days 306.1
TCGA-IB-A5SS-01A 64 years, female, white, stage:iib, dead, 460 days 301.9
TCGA-H8-A6C1-01A 53 years, male, white, stage:iia, alive, 671 days 300.6
TCGA-HZ-7926-01A 57 years, male, black or african american, stage:iib, dead, 518 days 300.5
TCGA-F2-6880-01A 70 years, male, white, stage:iib, alive, 289 days 299.5
TCGA-HZ-A4BK-01A 72 years, male, white, stage:iib, alive, 657 days 297.5
TCGA-F2-7276-01A 64 years, male, white, stage:iib, dead, 216 days 295.4
TCGA-HZ-8002-01A 61 years, male, white, stage:iib, dead, 366 days 294.5
TCGA-M8-A5N4-01A 48 years, female, stage:iia, alive, 584 days 293.2
TCGA-2J-AAB8-01A 71 years, male, white, stage:iib, alive, 80 days 292.9
TCGA-S4-A8RM-01A 67 years, male, white, stage:iib, alive, 737 days 290.5
TCGA-IB-AAUT-01A 65 years, male, white, stage:iib, alive, 287 days 288.1
TCGA-HZ-7923-01A 65 years, male, white, stage:iia, alive, 314 days 284.4
TCGA-IB-A5SO-01A 71 years, male, white, stage:iib, dead, 365 days 283.3
TCGA-RB-AA9M-01A 43 years, male, white, stage:iib, alive, 286 days 283.3
TCGA-XN-A8T3-01A 67 years, male, white, stage:ib, alive, 951 days 282.7
TCGA-HZ-7925-01A 66 years, male, white, stage:iib, dead, 614 days 282.1
TCGA-2J-AABO-01A 43 years, male, white, stage:iib, alive, 440 days 282.0
TCGA-2J-AABU-01A 56 years, male, white, stage:iib, dead, 277 days 280.4
TCGA-3A-A9I9-01A 67 years, male, white, stage:iia, dead, 634 days 278.3
TCGA-HV-A5A3-01A 50 years, male, asian, stage:iia, dead, 128 days 277.2
TCGA-HZ-8003-01A 65 years, female, white, stage:iib, dead, 596 days 276.5
TCGA-2J-AABH-01A 61 years, male, white, stage:iia, alive, 1287 days 275.5
TCGA-HZ-7918-01A 72 years, male, white, stage:iib, alive, 969 days 274.8
TCGA-IB-7654-01A 80 years, male, white, stage:iib, dead, 476 days 274.1
TCGA-IB-AAUQ-01A 50 years, male, white, stage:iib, dead, 183 days 273.8
TCGA-2J-AABE-01A 73 years, male, white, stage:iia, alive, 676 days 273.1
TCGA-3A-A9I7-01A 45 years, male, black or african american, stage:iib, alive, 1323 days 272.4
TCGA-3E-AAAY-01A 67 years, male, white, stage:iib, alive, 2285 days 270.8
TCGA-F2-7273-01A 54 years, male, black or african american, stage:iib, dead, 592 days 269.8
TCGA-3A-A9IZ-01A 47 years, male, white, stage:iib, dead, 308 days 269.8
TCGA-YB-A89D-01A 59 years, male, white, stage:iib, alive, 350 days 268.6
TCGA-HZ-A77P-01A 77 years, male, white, stage:iib, alive, 330 days 263.8
TCGA-HZ-A49I-01A 77 years, male, white, stage:iib, dead, 308 days 259.0
TCGA-2J-AAB4-01A 48 years, male, white, stage:iib, alive, 729 days 251.6
TCGA-2J-AAB6-01A 75 years, male, white, stage:iia, dead, 293 days 247.8
TCGA-HZ-8005-01A 81 years, male, white, stage:iib, dead, 120 days 241.6
TCGA-IB-7646-01A 60 years, male, white, stage:iib, dead, 145 days 229.7
TCGA-HV-AA8V-01A 50 years, male, asian, stage:iib, alive, 920 days 229.1
TCGA-3A-A9J0-01A 75 years, male, white, stage:iib, alive, 743 days 228.4
TCGA-IB-7893-01A 64 years, male, white, stage:iia, dead, 117 days 228.3
TCGA-US-A77G-01A 64 years, male, white, stage:iib, dead, 12 days 226.0
TCGA-HZ-A4BH-01A 75 years, male, white, stage:iib, alive, 194 days 225.0
TCGA-IB-AAUU-01A 35 years, male, white, stage:iib, alive, 245 days 223.9
TCGA-3A-A9IU-01A 65 years, male, white, stage:iib, dead, 458 days 223.3
TCGA-US-A77E-01A 73 years, male, white, stage:iib, dead, 430 days 222.2
TCGA-FB-A7DR-01A 48 years, male, asian, stage:iia, dead, 353 days 220.8
TCGA-FB-A545-01A 72 years, female, white, stage:iib, dead, 732 days 220.3
TCGA-IB-7890-01A 73 years, male, stage:ib, dead, 598 days 218.1
TCGA-2J-AABF-01A 73 years, male, white, stage:iib, dead, 691 days 216.3
TCGA-FB-A4P6-01A 54 years, male, white, stage:iib, alive, 767 days 214.1
TCGA-XD-AAUL-01A 56 years, male, white, stage:iia, alive, 498 days 206.0
TCGA-3A-A9IS-01A 67 years, male, white, stage:ib, alive, 998 days 145.9
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PANCREATIC CANCER - Protein expressioni

A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.

Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

 

Antibody stainingi

Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.

Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

Read more

Antibody HPA000857
 Staining
  High
  Medium
  Low
  Not detected
 Intensity
  Strong
  Moderate
  Weak
  Negative
 Quantity
  >75%
  75%-25%
  <25%
  None
 Location
  Nuclear
  Cytoplasmic/membranous
  Cytoplasmic/membranous,nuclear
  None
Click images for details

Contact

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The Project

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.