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The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
CAB000050
Moderate to strong background was observed in all tissues. More specific expression was found in germinal centers and plasma cells.
In many tumors unspecific staining was found. Stroma often showed background. Some lymphomas showed specific membranous and cytoplasmic expression. Plasma cells in stroma were positive.
CAB016533
Most normal tissues displayed weak immunoreactivity or negative cells. Lymphoid tissues showed a subset of strongly stained cells in the paracortex. Moderate positivity was observed in umbrella cells of the urinary bladder, renal tubuli, Leydig cells and trophoblasts. The malignant cells were generally negative only occasional cases were stained. Tumor stroma was strongly stained in several cancers.
The Human Protein Atlas project is funded
