Single cell type - CCL23 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCL23
Gene descriptionⁱ Full gene name according to HGNC.	C-C motif chemokine ligand 23
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Endothelial cells, Fibroblasts, Distal enterocytes, Paneth cells, Kupffer cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type. Read more	0.87
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Endothelial cells, Fibroblasts, Distal enterocytes, Paneth cells, Kupffer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Salivary gland Skeletal muscle Skin Small intestine Spleen Stomach Testis Thymus Tongue Vascular

EXPRESSION CLUSTERING & CORRELATIONⁱ

CCL23 is part of cluster 66 Endothelial cells - Angiogenesis with confidenceⁱ 1
468 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FCN3	Ficolin 3	0.9272	66
RAMP3	Receptor activity modifying protein 3	0.8560	66
CCL14	C-C motif chemokine ligand 14	0.8513	66
SMAD6	SMAD family member 6	0.8465	66
FAM167B	Family with sequence similarity 167 member B	0.8219	66
IL33	Interleukin 33	0.8104	66
EXOC3L2	Exocyst complex component 3 like 2	0.7512	66
LIFR	LIF receptor subunit alpha	0.7404	66
FCN2	Ficolin 2	0.7276	66
OIT3	Oncoprotein induced transcript 3	0.7271	66
SHE	Src homology 2 domain containing E	0.7260	66
CLEC4M	C-type lectin domain family 4 member M	0.7056	66
DNASE1L3	Deoxyribonuclease 1 like 3	0.7032	66
STAB1	Stabilin 1	0.7007	66
NPR1	Natriuretic peptide receptor 1	0.6985	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Salivary gland
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis
Cluster Expression Alphabetical Thymus
Cluster Expression Alphabetical Tongue
Cluster Expression Alphabetical Vascular

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

Adipocytes	14.0 nTPM
Breast	19.1 nTPM
Adipose tissue	8.8 nTPM

Alveolar cells type 1	1.9 nTPM
Lung	1.9 nTPM

Alveolar cells type 2	2.0 nTPM
Lung	2.0 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	0.8 nTPM
Liver	4.9 nTPM
Skin	1.7 nTPM
Lung	1.4 nTPM
Thymus	1.3 nTPM
Stomach	0.4 nTPM
Lymph node	0.3 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Salivary gland	0.0 nTPM

Club cells	1.4 nTPM
Lung	3.4 nTPM
Prostate	0.6 nTPM
Bronchus	0.0 nTPM

Endothelial cells	91.3 nTPM
Liver	337.1 nTPM
Lung	234.5 nTPM
Thymus	178.6 nTPM
Esophagus	166.4 nTPM
Prostate	162.4 nTPM
Salivary gland	111.6 nTPM
Tongue	96.5 nTPM
Vascular	57.9 nTPM
Placenta	57.0 nTPM
Skin	53.5 nTPM
Endometrium	36.7 nTPM
Testis	22.0 nTPM
Heart muscle	20.9 nTPM
Skeletal muscle	8.6 nTPM
Ovary	7.2 nTPM
Breast	0.9 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	0.1 nTPM
Colon	0.4 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	39.6 nTPM
Liver	612.1 nTPM
Stomach	8.8 nTPM
Thymus	6.9 nTPM
Lung	3.0 nTPM
Vascular	1.1 nTPM
Prostate	0.7 nTPM
Skin	0.2 nTPM
Salivary gland	0.2 nTPM
Placenta	0.1 nTPM
Esophagus	0.1 nTPM
Heart muscle	0.0 nTPM
Pancreas	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Ovary	0.0 nTPM
Breast	0.0 nTPM

Intestinal goblet cells	0.2 nTPM
Small intestine	0.7 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	7.3 nTPM
Lung	47.7 nTPM
Vascular	21.6 nTPM
Liver	20.9 nTPM
Thymus	14.4 nTPM
Ovary	12.7 nTPM
Kidney	11.6 nTPM
Bone marrow	4.1 nTPM
Endometrium	3.7 nTPM
Skin	3.4 nTPM
Spleen	3.1 nTPM
Adipose tissue	2.7 nTPM
Salivary gland	1.8 nTPM
Esophagus	1.3 nTPM
Breast	1.1 nTPM
Prostate	0.9 nTPM
Skeletal muscle	0.8 nTPM
Tongue	0.7 nTPM
Testis	0.6 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	32.9 nTPM
Small intestine	52.6 nTPM
Colon	25.6 nTPM
Rectum	20.5 nTPM

Plasma cells	1.8 nTPM
Liver	10.1 nTPM
Thymus	2.0 nTPM
Salivary gland	0.5 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	1.1 nTPM
Lung	2.0 nTPM
Bronchus	0.1 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Basal prostatic cells	3.6 nTPM
Prostate	3.6 nTPM

Early spermatids	2.2 nTPM
Testis	2.2 nTPM

Serous glandular cells	2.4 nTPM
Tongue	4.5 nTPM
Salivary gland	0.4 nTPM

Smooth muscle cells	5.7 nTPM
Liver	86.5 nTPM
Esophagus	2.4 nTPM
Thymus	2.4 nTPM
Prostate	1.2 nTPM
Ovary	0.9 nTPM
Heart muscle	0.5 nTPM
Salivary gland	0.5 nTPM
Breast	0.5 nTPM
Skin	0.3 nTPM
Skeletal muscle	0.3 nTPM
Tongue	0.3 nTPM
Vascular	0.3 nTPM
Placenta	0.1 nTPM
Endometrium	0.0 nTPM
Bronchus	0.0 nTPM
Adipose tissue	0.0 nTPM
Lung	0.0 nTPM

T-cells	0.9 nTPM
Vascular	4.5 nTPM
Liver	3.7 nTPM
Skeletal muscle	2.7 nTPM
Placenta	1.6 nTPM
Lung	1.6 nTPM
Prostate	1.3 nTPM
Bone marrow	1.1 nTPM
Endometrium	0.5 nTPM
Skin	0.4 nTPM
Adipose tissue	0.4 nTPM
Tongue	0.3 nTPM
Lymph node	0.2 nTPM
Breast	0.2 nTPM
Spleen	0.1 nTPM
Stomach	0.1 nTPM
Thymus	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Salivary gland	0.0 nTPM

Undifferentiated cells	0.2 nTPM
Small intestine	0.2 nTPM
Rectum	0.2 nTPM
Colon	0.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Salivary gland

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

Thymus

Tongue

Vascular

PBMC