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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:286.1 nTPM
HPA:286.1 nTPM
GTEx:205.8 nTPM
FANTOM5:310.5 Scaled Tags Per Million
Pig:133.1 nTPM
Mouse:68.2 nTPM
Allen mouse:7.8 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 286.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 248.9
2666 Male, age 74, left hemisphere 301.9
1833 Male, age 53, unknown 283.4
1830 Male, age 51, unknown 281.9
2586 Male, age 75, left hemisphere 265.7
2411 Female, age 72, unknown 244.4
1870 Female, age 42, unknown 241.1
2828 Female, age 72, unknown 237.2
2019 Male, age 18, unknown 225.1
2219 Male, age 76, both hemispheres 205.2
1827 Male, age 72, unknown 203.4
Dorsal raphe nucleus
nTPM: 187.6
2750 Male, age 76, both hemispheres 245.0
2016 Female, age 72, unknown 206.3
1828 Male, age 53, unknown 190.7
2047 Male, age 72, unknown 159.0
2298 Female, age 72, unknown 137.2
Inferior colliculus
nTPM: 188.0
2849 Male, age 72, unknown 214.2
1848 Female, age 42, unknown 199.4
1890 Male, age 53, unknown 187.9
2097 Female, age 72, unknown 150.8
Median raphe nucleus
nTPM: 185.9
2220 Male, age 76, midline 185.9
Pedunculopontine tegmental nucleus
nTPM: 222.1
2338 Male, age 61, both hemispheres 260.0
2334 Male, age 80, both hemispheres 221.1
1921 Female, age 85, both hemispheres 185.2
Periaquaductal grey, anterior
nTPM: 181.3
2502 Female, age 75, unknown 191.0
1947 Male, age 18, unknown 186.5
1795 Male, age 51, unknown 166.5
Periaquaductal grey, dorsal
nTPM: 170.6
2464 Female, age 72, unknown 202.4
1831 Male, age 72, unknown 177.4
2850 Male, age 76, both hemispheres 161.4
1840 Male, age 53, unknown 141.0
Periaquaductal grey, lateral
nTPM: 170.1
2053 Male, age 18, unknown 181.8
2140 Male, age 76, both hemispheres 165.3
2272 Male, age 74, both hemispheres 163.0
Pretectal area
nTPM: 182.5
1815 Male, age 53, unknown 231.2
2316 Male, age 76, right hemisphere 225.1
2407 Male, age 75, both hemispheres 224.0
2825 Male, age 18, unknown 200.0
1817 Female, age 42, unknown 198.8
2007 Male, age 72, unknown 179.5
2224 Female, age 72, unknown 158.0
2273 Male, age 74, both hemispheres 148.4
1944 Female, age 72, unknown 148.0
1816 Male, age 51, unknown 147.7
2667 Female, age 75, unknown 147.1
Red nucleus
nTPM: 286.1
2503 Female, age 72, unknown 332.1
1865 Male, age 51, unknown 323.4
1904 Male, age 53, unknown 302.2
2588 Male, age 74, left hemisphere 296.4
2227 Male, age 72, unknown 296.3
2769 Male, age 72, unknown 291.3
2823 Male, age 76, right hemisphere 289.6
1821 Female, age 72, unknown 274.8
1954 Female, age 42, unknown 268.8
2725 Female, age 75, unknown 266.0
2785 Male, age 18, unknown 266.0
2584 Male, age 75, left hemisphere 226.8
Substantia nigra
nTPM: 194.2
2699 Male, age 18, unknown 232.9
2665 Male, age 74, both hemispheres 210.5
2590 Female, age 75, unknown 208.6
1851 Male, age 51, unknown 202.4
2409 Female, age 72, unknown 202.3
2583 Male, age 75, right hemisphere 199.4
1889 Female, age 72, unknown 191.0
1941 Male, age 53, unknown 177.0
2241 Male, age 72, unknown 160.1
1916 Female, age 42, unknown 157.5
Superior colliculus
nTPM: 222.9
1995 Male, age 72, unknown 287.8
1913 Female, age 42, unknown 282.7
2668 Female, age 75, unknown 251.2
2587 Male, age 74, left hemisphere 234.1
1839 Male, age 51, unknown 228.0
1895 Male, age 76, right hemisphere 223.1
2664 Male, age 75, both hemispheres 206.9
1796 Male, age 53, unknown 186.5
2261 Male, age 18, unknown 166.9
2087 Female, age 72, unknown 162.1
Ventral tegmental area
nTPM: 201.5
2223 Female, age 72, unknown 240.6
2410 Female, age 72, unknown 214.6
1942 Male, age 51, unknown 194.1
2021 Male, age 53, unknown 189.1
2218 Male, age 76, both hemispheres 188.7
1915 Female, age 42, unknown 182.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 205.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 205.8
Samples: 139

Max nTPM: 538.4
Min nTPM: 63.7
Std nTPM: 102.3
Median nTPM: 186.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 538.4
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 466.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 466.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 464.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 430.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 430.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 422.7
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 410.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 399.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 397.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 389.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 376.4
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 373.0
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 368.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 344.4
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 335.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 332.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 319.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 315.9
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 314.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 313.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 310.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 307.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 305.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 304.1
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 303.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 302.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 294.0
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 293.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 291.8
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 290.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 279.9
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 274.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 270.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 269.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 267.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 267.3
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 256.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 252.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 241.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 241.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 239.4
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 238.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 237.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 236.2
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 231.9
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 231.7
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 230.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 229.4
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 228.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 228.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 220.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 215.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 214.1
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 212.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 212.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 211.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 211.3
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 211.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 209.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 203.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 203.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 201.5
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 197.0
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 194.8
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 194.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 192.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 191.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 186.5
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 186.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 185.8
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 184.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 181.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 178.7
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 178.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 177.7
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 176.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 174.7
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 174.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 169.5
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 162.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 162.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 155.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 151.9
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 149.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 149.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 147.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 146.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 145.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 145.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 144.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 142.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 138.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 137.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 136.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 135.6
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 135.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 127.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 123.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 121.1
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 119.8
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 118.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 118.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 117.4
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 116.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 116.2
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 116.1
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 116.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 115.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 115.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 114.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 114.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 113.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 111.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 111.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 110.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 108.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 107.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 107.3
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 106.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 106.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 105.6
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 101.2
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 100.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 96.8
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 96.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 96.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 95.7
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 94.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 92.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 92.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 91.3
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 81.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 76.1
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 72.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 72.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 64.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 64.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 63.7
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 310.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 310.5
FF:10158-103A5 76 years, female 310.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 133.1
Pig sample Sample description nTPM
Midbrain
nTPM: 123.3
Samples: 4

Max nTPM: 189.0
Min nTPM: 79.6
Sample A Female 189.0
Sample B Female 139.7
Sample C Male 79.6
Sample D Male 84.9
Periaqueductal gray
nTPM: 96.3
Samples: 3

Max nTPM: 111.6
Min nTPM: 84.5
Sample B Female 111.6
Sample C Male 84.5
Sample D Male 92.8
Substantia nigra
nTPM: 133.2
Samples: 4

Max nTPM: 192.2
Min nTPM: 110.0
Sample A Female 114.2
Sample B Female 110.0
Sample C Male 116.2
Sample D Male 192.2
Superior colliculi
nTPM: 92.3
Samples: 4

Max nTPM: 119.0
Min nTPM: 58.1
Sample A Female 95.3
Sample B Female 58.1
Sample C Male 96.9
Sample D Male 119.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 68.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 68.2
Samples: 4

Max nTPM: 69.4
Min nTPM: 67.0
Sample A Male 67.1
Sample B Male 67.0
Sample C Female 69.4
Sample D Female 69.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 7.8
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 7.8
69752041 Antisense, RP_050505_01_A02, Mouse strain C57BL/6J (56 days, male) 7.8

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