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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:2338.9 nTPM
HPA:2338.9 nTPM
GTEx:1308.8 nTPM
FANTOM5:2245.7 Scaled Tags Per Million
Pig:1926.3 nTPM
Mouse:591.4 nTPM
Allen mouse:23.3 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 2338.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 2124.6
1870 Female, age 42, unknown 2240.9
2019 Male, age 18, unknown 2233.6
1830 Male, age 51, unknown 2199.5
2411 Female, age 72, unknown 2192.6
1833 Male, age 53, unknown 2167.7
2828 Female, age 72, unknown 2139.8
2666 Male, age 74, left hemisphere 2119.9
1827 Male, age 72, unknown 2041.7
2586 Male, age 75, left hemisphere 2004.0
2219 Male, age 76, both hemispheres 1906.7
Dorsal raphe nucleus
nTPM: 2072.6
2750 Male, age 76, both hemispheres 2227.7
2298 Female, age 72, unknown 2089.5
1828 Male, age 53, unknown 2063.5
2016 Female, age 72, unknown 1994.0
2047 Male, age 72, unknown 1988.4
Inferior colliculus
nTPM: 2025.0
1848 Female, age 42, unknown 2059.9
2097 Female, age 72, unknown 2029.0
1890 Male, age 53, unknown 2011.6
2849 Male, age 72, unknown 1999.4
Median raphe nucleus
nTPM: 2142.1
2220 Male, age 76, midline 2142.1
Pedunculopontine tegmental nucleus
nTPM: 2338.9
2338 Male, age 61, both hemispheres 2771.6
2334 Male, age 80, both hemispheres 2301.1
1921 Female, age 85, both hemispheres 1944.1
Periaquaductal grey, anterior
nTPM: 2028.3
1947 Male, age 18, unknown 2062.5
1795 Male, age 51, unknown 2054.5
2502 Female, age 75, unknown 1967.9
Periaquaductal grey, dorsal
nTPM: 1976.7
2850 Male, age 76, both hemispheres 2055.5
1831 Male, age 72, unknown 2013.7
2464 Female, age 72, unknown 1957.2
1840 Male, age 53, unknown 1880.6
Periaquaductal grey, lateral
nTPM: 2051.6
2272 Male, age 74, both hemispheres 2171.3
2140 Male, age 76, both hemispheres 1993.9
2053 Male, age 18, unknown 1989.7
Pretectal area
nTPM: 2106.3
1817 Female, age 42, unknown 2257.4
1815 Male, age 53, unknown 2162.9
2007 Male, age 72, unknown 2157.5
1944 Female, age 72, unknown 2147.1
2273 Male, age 74, both hemispheres 2142.2
2667 Female, age 75, unknown 2082.7
1816 Male, age 51, unknown 2079.3
2407 Male, age 75, both hemispheres 2074.7
2224 Female, age 72, unknown 2044.3
2316 Male, age 76, right hemisphere 2016.9
2825 Male, age 18, unknown 2004.7
Red nucleus
nTPM: 2253.0
1865 Male, age 51, unknown 2352.2
2769 Male, age 72, unknown 2332.1
1904 Male, age 53, unknown 2330.9
2227 Male, age 72, unknown 2327.3
2785 Male, age 18, unknown 2308.5
1821 Female, age 72, unknown 2291.1
1954 Female, age 42, unknown 2288.9
2725 Female, age 75, unknown 2282.3
2503 Female, age 72, unknown 2247.4
2823 Male, age 76, right hemisphere 2209.1
2584 Male, age 75, left hemisphere 2102.8
2588 Male, age 74, left hemisphere 1963.6
Substantia nigra
nTPM: 2122.1
2583 Male, age 75, right hemisphere 2316.5
2590 Female, age 75, unknown 2281.9
1889 Female, age 72, unknown 2128.5
1851 Male, age 51, unknown 2125.5
1916 Female, age 42, unknown 2120.8
1941 Male, age 53, unknown 2118.4
2665 Male, age 74, both hemispheres 2086.4
2699 Male, age 18, unknown 2062.3
2409 Female, age 72, unknown 2032.7
2241 Male, age 72, unknown 1948.2
Superior colliculus
nTPM: 2096.7
1913 Female, age 42, unknown 2284.2
1995 Male, age 72, unknown 2241.1
2587 Male, age 74, left hemisphere 2225.0
1796 Male, age 53, unknown 2131.4
2261 Male, age 18, unknown 2114.3
2087 Female, age 72, unknown 2088.5
1839 Male, age 51, unknown 2047.5
2668 Female, age 75, unknown 2003.2
1895 Male, age 76, right hemisphere 1932.1
2664 Male, age 75, both hemispheres 1899.6
Ventral tegmental area
nTPM: 2169.5
2223 Female, age 72, unknown 2419.7
2218 Male, age 76, both hemispheres 2197.7
2410 Female, age 72, unknown 2196.6
1915 Female, age 42, unknown 2099.8
2021 Male, age 53, unknown 2076.4
1942 Male, age 51, unknown 2026.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1308.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 1308.8
Samples: 139

Max nTPM: 3194.1
Min nTPM: 646.7
Std nTPM: 490.2
Median nTPM: 1135.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 3194.1
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 2998.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 2900.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 2888.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 2816.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 2710.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 2677.3
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 2520.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 2338.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 2290.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 2162.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 2084.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 1981.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 1949.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 1866.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 1816.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 1738.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1711.4
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 1687.1
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 1683.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 1674.4
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 1671.7
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 1626.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1624.3
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 1594.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 1585.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 1571.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 1571.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1545.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 1498.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 1468.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 1462.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 1460.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 1454.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1421.7
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 1421.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 1421.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 1383.0
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 1375.3
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 1371.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 1368.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 1367.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 1365.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 1362.0
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1354.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 1329.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 1325.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 1317.2
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 1310.5
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1306.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1286.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1283.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 1269.6
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 1237.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 1214.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 1212.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1197.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 1184.6
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 1178.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 1177.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 1173.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 1170.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 1156.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 1146.9
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 1145.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 1143.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 1141.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 1141.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 1137.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 1135.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 1131.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 1130.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 1129.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 1126.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 1123.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 1117.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 1108.0
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 1105.5
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1104.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 1100.0
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 1098.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 1092.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1092.0
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 1089.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 1086.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 1082.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 1081.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 1080.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 1074.2
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 1072.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 1065.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 1063.1
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 1061.7
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 1060.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 1044.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 1043.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 1042.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 1036.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 1027.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 1025.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 1023.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 1022.2
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 1019.5
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1018.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 1011.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 1008.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 997.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 996.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 993.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 985.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 982.4
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 982.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 979.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 978.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 977.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 974.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 963.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 961.8
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 961.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 958.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 957.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 948.4
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 937.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 930.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 924.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 922.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 906.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 901.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 885.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 867.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 860.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 847.3
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 845.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 843.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 800.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 766.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 746.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 728.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 646.7
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 2245.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 2245.7
FF:10158-103A5 76 years, female 2245.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1926.3
Pig sample Sample description nTPM
Midbrain
nTPM: 1926.3
Samples: 4

Max nTPM: 3268.3
Min nTPM: 1262.0
Sample A Female 3268.3
Sample B Female 1684.9
Sample C Male 1490.0
Sample D Male 1262.0
Periaqueductal gray
nTPM: 1435.9
Samples: 3

Max nTPM: 1641.0
Min nTPM: 1225.3
Sample B Female 1441.4
Sample C Male 1641.0
Sample D Male 1225.3
Substantia nigra
nTPM: 1843.7
Samples: 4

Max nTPM: 2073.3
Min nTPM: 1615.8
Sample A Female 2073.3
Sample B Female 1615.8
Sample C Male 1856.7
Sample D Male 1829.1
Superior colliculi
nTPM: 1736.2
Samples: 4

Max nTPM: 2043.7
Min nTPM: 1480.9
Sample A Female 2043.7
Sample B Female 1480.9
Sample C Male 1714.4
Sample D Male 1705.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 591.4
Mouse sample Sample description nTPM
Midbrain
nTPM: 591.4
Samples: 4

Max nTPM: 651.5
Min nTPM: 554.1
Sample A Male 651.5
Sample B Male 563.7
Sample C Female 554.1
Sample D Female 596.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 23.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 23.3
74881516 Antisense, RP_060315_04_C04, Mouse strain C57BL/6J (56 days, male) 25.3
81600126 Antisense, RP_080306_03_B07, Mouse strain C57BL/6J (56 days, male) 25.2
69514684 Antisense, RP_050419_03_H03, Mouse strain C57BL/6J (56 days, male) 19.4

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.