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GNB1
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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:153.2 nTPM
HPA:153.2 nTPM
GTEx:185.7 nTPM
FANTOM5:228.7 Scaled Tags Per Million
Pig:148.0 nTPM
Mouse:318.9 nTPM
Allen mouse:6.7 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 153.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 137.7
1827 Male, age 72, unknown 163.1
2666 Male, age 74, left hemisphere 162.7
2586 Male, age 75, left hemisphere 150.0
2219 Male, age 76, both hemispheres 139.2
2411 Female, age 72, unknown 134.6
1870 Female, age 42, unknown 132.9
2828 Female, age 72, unknown 131.8
1833 Male, age 53, unknown 125.1
2019 Male, age 18, unknown 121.6
1830 Male, age 51, unknown 116.0
Dorsal raphe nucleus
nTPM: 129.3
2298 Female, age 72, unknown 140.0
2047 Male, age 72, unknown 138.6
2750 Male, age 76, both hemispheres 132.9
1828 Male, age 53, unknown 129.9
2016 Female, age 72, unknown 105.2
Inferior colliculus
nTPM: 139.6
2097 Female, age 72, unknown 148.2
1848 Female, age 42, unknown 143.6
2849 Male, age 72, unknown 138.3
1890 Male, age 53, unknown 128.2
Median raphe nucleus
nTPM: 152.8
2220 Male, age 76, midline 152.8
Pedunculopontine tegmental nucleus
nTPM: 138.6
1921 Female, age 85, both hemispheres 156.3
2334 Male, age 80, both hemispheres 138.0
2338 Male, age 61, both hemispheres 121.6
Periaquaductal grey, anterior
nTPM: 153.2
1947 Male, age 18, unknown 163.4
1795 Male, age 51, unknown 161.9
2502 Female, age 75, unknown 134.4
Periaquaductal grey, dorsal
nTPM: 121.4
1831 Male, age 72, unknown 135.7
1840 Male, age 53, unknown 124.3
2850 Male, age 76, both hemispheres 120.9
2464 Female, age 72, unknown 104.7
Periaquaductal grey, lateral
nTPM: 111.6
2053 Male, age 18, unknown 119.7
2272 Male, age 74, both hemispheres 116.3
2140 Male, age 76, both hemispheres 98.9
Pretectal area
nTPM: 143.6
1944 Female, age 72, unknown 192.0
1816 Male, age 51, unknown 182.8
1817 Female, age 42, unknown 172.7
2007 Male, age 72, unknown 167.1
1815 Male, age 53, unknown 157.1
2667 Female, age 75, unknown 138.5
2825 Male, age 18, unknown 128.4
2224 Female, age 72, unknown 116.8
2407 Male, age 75, both hemispheres 111.0
2273 Male, age 74, both hemispheres 109.5
2316 Male, age 76, right hemisphere 104.0
Red nucleus
nTPM: 115.8
1821 Female, age 72, unknown 136.3
2725 Female, age 75, unknown 124.5
2584 Male, age 75, left hemisphere 123.0
2785 Male, age 18, unknown 122.8
1954 Female, age 42, unknown 118.0
1904 Male, age 53, unknown 117.2
1865 Male, age 51, unknown 113.6
2769 Male, age 72, unknown 110.4
2227 Male, age 72, unknown 109.5
2503 Female, age 72, unknown 105.6
2588 Male, age 74, left hemisphere 104.8
2823 Male, age 76, right hemisphere 104.0
Substantia nigra
nTPM: 148.1
1916 Female, age 42, unknown 181.7
1889 Female, age 72, unknown 176.3
2665 Male, age 74, both hemispheres 171.4
1941 Male, age 53, unknown 152.5
1851 Male, age 51, unknown 152.2
2583 Male, age 75, right hemisphere 136.2
2699 Male, age 18, unknown 136.2
2590 Female, age 75, unknown 130.7
2409 Female, age 72, unknown 127.6
2241 Male, age 72, unknown 116.4
Superior colliculus
nTPM: 140.6
2668 Female, age 75, unknown 167.9
1796 Male, age 53, unknown 165.5
2261 Male, age 18, unknown 151.7
2087 Female, age 72, unknown 148.0
1895 Male, age 76, right hemisphere 143.8
2587 Male, age 74, left hemisphere 136.4
1913 Female, age 42, unknown 134.8
1839 Male, age 51, unknown 123.7
2664 Male, age 75, both hemispheres 120.7
1995 Male, age 72, unknown 113.6
Ventral tegmental area
nTPM: 149.3
2218 Male, age 76, both hemispheres 169.9
2410 Female, age 72, unknown 161.9
2223 Female, age 72, unknown 152.1
1915 Female, age 42, unknown 150.5
1942 Male, age 51, unknown 139.9
2021 Male, age 53, unknown 121.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 185.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 185.7
Samples: 139

Max nTPM: 343.5
Min nTPM: 125.3
Std nTPM: 38.8
Median nTPM: 172.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 343.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 315.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 282.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 278.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 272.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 271.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 269.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 261.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 260.4
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 259.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 258.2
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 257.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 253.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 252.6
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 246.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 241.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 236.4
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 228.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 228.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 227.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 224.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 221.9
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 219.8
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 218.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 218.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 214.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 212.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 209.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 207.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 207.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 206.9
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 206.1
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 204.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 204.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 204.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 201.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 200.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 200.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 197.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 197.1
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 196.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 195.3
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 195.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 194.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 194.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 192.0
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 191.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 191.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 189.8
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 189.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 189.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 188.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 188.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 186.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 185.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 183.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 182.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 182.5
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 181.8
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 181.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 181.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 180.6
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 179.0
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 177.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 176.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 176.0
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 174.0
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 173.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 172.8
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 172.8
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 172.4
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 172.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 170.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 170.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 170.3
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 170.2
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 169.9
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 169.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 167.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 167.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 167.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 167.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 167.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 167.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 166.8
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 166.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 166.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 165.5
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 165.3
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 165.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 164.0
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 163.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 163.3
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 162.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 162.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 162.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 162.0
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 161.3
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 160.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 160.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 159.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 159.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 159.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 159.3
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 158.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 158.2
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 158.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 157.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 156.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 155.2
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 155.2
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 155.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 153.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 153.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 153.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 153.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 153.1
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 152.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 151.5
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 151.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 151.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 149.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 149.5
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 148.9
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 148.8
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 148.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 148.6
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 148.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 148.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 147.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 147.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 147.1
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 144.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 143.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 142.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 137.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 137.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 127.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 125.3
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 228.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 228.7
FF:10158-103A5 76 years, female 228.7

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 148.0
Pig sample Sample description nTPM
Midbrain
nTPM: 148.1
Samples: 4

Max nTPM: 172.3
Min nTPM: 115.1
Sample A Female 149.2
Sample B Female 115.1
Sample C Male 172.3
Sample D Male 155.7
Periaqueductal gray
nTPM: 105.5
Samples: 3

Max nTPM: 123.0
Min nTPM: 88.8
Sample B Female 104.8
Sample C Male 123.0
Sample D Male 88.8
Substantia nigra
nTPM: 131.9
Samples: 4

Max nTPM: 174.5
Min nTPM: 93.8
Sample A Female 174.5
Sample B Female 110.1
Sample C Male 149.1
Sample D Male 93.8
Superior colliculi
nTPM: 145.8
Samples: 4

Max nTPM: 168.9
Min nTPM: 125.9
Sample A Female 168.9
Sample B Female 125.9
Sample C Male 147.6
Sample D Male 140.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 318.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 318.9
Samples: 4

Max nTPM: 328.4
Min nTPM: 312.9
Sample A Male 312.9
Sample B Male 313.0
Sample C Female 328.4
Sample D Female 321.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 6.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 6.7
61413 Antisense, RP_040407_01_C10, Mouse strain C57BL/6J (56 days, male) 13.0
70786827 Antisense, RP_050706_03_D02, Mouse strain C57BL/6J (56 days, male) 3.8
68203457 Antisense, RP_041208_01_A04, Mouse strain C57BL/6J (56 days, male) 3.3

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