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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:86.7 nTPM
HPA:86.7 nTPM
GTEx:84.2 nTPM
FANTOM5:140.3 Scaled Tags Per Million
Pig:142.4 nTPM
Mouse:88.8 nTPM
Allen mouse:4.2 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 86.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 73.8
2586 Male, age 75, left hemisphere 90.9
2828 Female, age 72, unknown 86.8
2666 Male, age 74, left hemisphere 79.6
1870 Female, age 42, unknown 78.5
1827 Male, age 72, unknown 76.7
1833 Male, age 53, unknown 70.9
2411 Female, age 72, unknown 67.9
2219 Male, age 76, both hemispheres 66.3
1830 Male, age 51, unknown 63.6
2019 Male, age 18, unknown 56.4
Dorsal raphe nucleus
nTPM: 86.7
2047 Male, age 72, unknown 104.3
1828 Male, age 53, unknown 93.8
2016 Female, age 72, unknown 85.7
2298 Female, age 72, unknown 76.7
2750 Male, age 76, both hemispheres 73.1
Inferior colliculus
nTPM: 85.5
1848 Female, age 42, unknown 91.8
2849 Male, age 72, unknown 89.1
1890 Male, age 53, unknown 82.5
2097 Female, age 72, unknown 78.6
Median raphe nucleus
nTPM: 80.1
2220 Male, age 76, midline 80.1
Pedunculopontine tegmental nucleus
nTPM: 67.4
1921 Female, age 85, both hemispheres 74.7
2334 Male, age 80, both hemispheres 67.1
2338 Male, age 61, both hemispheres 60.5
Periaquaductal grey, anterior
nTPM: 85.4
1947 Male, age 18, unknown 86.1
2502 Female, age 75, unknown 85.4
1795 Male, age 51, unknown 84.8
Periaquaductal grey, dorsal
nTPM: 86.0
1840 Male, age 53, unknown 97.8
2850 Male, age 76, both hemispheres 88.6
2464 Female, age 72, unknown 83.4
1831 Male, age 72, unknown 74.0
Periaquaductal grey, lateral
nTPM: 80.0
2140 Male, age 76, both hemispheres 93.8
2053 Male, age 18, unknown 89.7
2272 Male, age 74, both hemispheres 56.6
Pretectal area
nTPM: 75.5
1816 Male, age 51, unknown 86.8
1944 Female, age 72, unknown 85.4
2667 Female, age 75, unknown 85.3
1817 Female, age 42, unknown 85.1
2825 Male, age 18, unknown 83.6
2224 Female, age 72, unknown 81.3
2316 Male, age 76, right hemisphere 76.3
1815 Male, age 53, unknown 71.4
2007 Male, age 72, unknown 64.4
2407 Male, age 75, both hemispheres 55.9
2273 Male, age 74, both hemispheres 55.0
Red nucleus
nTPM: 78.9
2823 Male, age 76, right hemisphere 98.3
1954 Female, age 42, unknown 93.2
2769 Male, age 72, unknown 84.0
2227 Male, age 72, unknown 83.6
2503 Female, age 72, unknown 83.3
1821 Female, age 72, unknown 83.2
2588 Male, age 74, left hemisphere 82.8
1904 Male, age 53, unknown 78.7
2725 Female, age 75, unknown 76.4
1865 Male, age 51, unknown 68.9
2584 Male, age 75, left hemisphere 59.9
2785 Male, age 18, unknown 54.1
Substantia nigra
nTPM: 83.2
2699 Male, age 18, unknown 116.0
2665 Male, age 74, both hemispheres 92.8
1916 Female, age 42, unknown 90.0
1851 Male, age 51, unknown 82.8
2409 Female, age 72, unknown 82.2
2241 Male, age 72, unknown 81.3
1889 Female, age 72, unknown 77.7
2590 Female, age 75, unknown 74.1
2583 Male, age 75, right hemisphere 67.7
1941 Male, age 53, unknown 67.3
Superior colliculus
nTPM: 73.7
2087 Female, age 72, unknown 84.1
1839 Male, age 51, unknown 79.8
2261 Male, age 18, unknown 78.9
1895 Male, age 76, right hemisphere 78.1
1796 Male, age 53, unknown 78.0
2664 Male, age 75, both hemispheres 72.2
2668 Female, age 75, unknown 71.1
2587 Male, age 74, left hemisphere 70.4
1995 Male, age 72, unknown 64.0
1913 Female, age 42, unknown 60.2
Ventral tegmental area
nTPM: 75.4
1915 Female, age 42, unknown 83.7
2410 Female, age 72, unknown 80.2
2218 Male, age 76, both hemispheres 79.9
1942 Male, age 51, unknown 75.5
2021 Male, age 53, unknown 74.7
2223 Female, age 72, unknown 58.5

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 84.2
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 84.2
Samples: 139

Max nTPM: 278.3
Min nTPM: 17.3
Std nTPM: 39.0
Median nTPM: 76.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 278.3
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 183.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 181.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 178.3
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 174.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 172.1
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 158.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 157.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 154.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 148.9
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 147.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 138.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 135.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 133.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 133.2
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 133.2
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 132.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 131.3
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 121.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 120.9
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 120.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 117.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 114.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 114.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 113.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 113.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 109.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 108.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 107.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 107.1
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 105.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 105.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 105.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 103.3
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 102.7
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 101.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 101.8
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 101.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 100.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 100.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 100.2
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 98.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 97.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 96.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 95.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 95.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 93.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 93.0
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 92.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 92.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 91.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 90.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 89.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 86.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 84.4
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 84.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 84.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 83.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 82.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 82.7
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 81.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 80.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 80.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 79.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 79.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 79.2
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 78.4
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 77.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 76.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 76.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 75.2
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 74.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 72.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 71.6
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 71.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 71.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 70.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 70.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 70.2
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 69.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 68.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 67.8
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 67.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 67.3
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 67.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 66.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 66.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 66.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 66.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 66.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 66.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 65.6
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 65.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 65.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 65.3
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 64.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 64.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 64.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 63.9
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 63.8
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 63.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 63.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 62.2
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 61.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 60.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 60.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 59.9
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 59.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 57.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 54.4
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 53.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 53.1
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 52.9
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 52.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 50.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 49.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 48.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 48.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 48.0
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 46.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 46.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 46.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 45.8
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 45.6
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 45.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 45.1
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 43.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 41.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 38.3
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 36.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 35.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 34.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 34.3
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 32.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 29.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 22.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 21.3
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 17.5
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 17.3
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 140.3
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 140.3
FF:10158-103A5 76 years, female 140.3

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 142.4
Pig sample Sample description nTPM
Midbrain
nTPM: 100.6
Samples: 4

Max nTPM: 132.2
Min nTPM: 75.1
Sample A Female 132.2
Sample B Female 92.1
Sample C Male 102.9
Sample D Male 75.1
Periaqueductal gray
nTPM: 79.1
Samples: 3

Max nTPM: 88.1
Min nTPM: 69.3
Sample B Female 79.9
Sample C Male 88.1
Sample D Male 69.3
Substantia nigra
nTPM: 134.0
Samples: 4

Max nTPM: 199.1
Min nTPM: 107.0
Sample A Female 117.0
Sample B Female 199.1
Sample C Male 107.0
Sample D Male 113.0
Superior colliculi
nTPM: 142.4
Samples: 4

Max nTPM: 229.4
Min nTPM: 93.4
Sample A Female 145.9
Sample B Female 229.4
Sample C Male 93.4
Sample D Male 100.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 88.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 88.8
Samples: 4

Max nTPM: 92.7
Min nTPM: 84.0
Sample A Male 91.5
Sample B Male 87.0
Sample C Female 92.7
Sample D Female 84.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 4.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 4.2
73769324 Antisense, RP_051121_04_B09, Mouse strain C57BL/6J (56 days, male) 4.5
69549650 Antisense, RP_050315_01_B12, Mouse strain C57BL/6J (56 days, male) 3.8

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