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SPTBN1
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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:154.4 nTPM
HPA:154.4 nTPM
GTEx:126.9 nTPM
FANTOM5:460.4 Scaled Tags Per Million
Pig:239.1 nTPM
Mouse:157.2 nTPM
Allen mouse:2.5 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 154.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 129.4
2586 Male, age 75, left hemisphere 247.8
2666 Male, age 74, left hemisphere 175.3
2828 Female, age 72, unknown 146.4
1827 Male, age 72, unknown 137.0
2019 Male, age 18, unknown 130.7
1870 Female, age 42, unknown 93.9
2411 Female, age 72, unknown 92.9
2219 Male, age 76, both hemispheres 91.7
1830 Male, age 51, unknown 90.9
1833 Male, age 53, unknown 87.2
Dorsal raphe nucleus
nTPM: 101.3
2047 Male, age 72, unknown 121.6
1828 Male, age 53, unknown 111.6
2016 Female, age 72, unknown 100.9
2750 Male, age 76, both hemispheres 88.9
2298 Female, age 72, unknown 83.7
Inferior colliculus
nTPM: 89.8
2849 Male, age 72, unknown 99.5
1890 Male, age 53, unknown 93.5
1848 Female, age 42, unknown 91.9
2097 Female, age 72, unknown 74.5
Median raphe nucleus
nTPM: 85.8
2220 Male, age 76, midline 85.8
Pedunculopontine tegmental nucleus
nTPM: 89.4
2334 Male, age 80, both hemispheres 101.9
1921 Female, age 85, both hemispheres 87.3
2338 Male, age 61, both hemispheres 78.9
Periaquaductal grey, anterior
nTPM: 138.9
1795 Male, age 51, unknown 142.7
2502 Female, age 75, unknown 140.1
1947 Male, age 18, unknown 133.9
Periaquaductal grey, dorsal
nTPM: 104.9
1840 Male, age 53, unknown 112.8
2850 Male, age 76, both hemispheres 112.7
1831 Male, age 72, unknown 105.8
2464 Female, age 72, unknown 88.1
Periaquaductal grey, lateral
nTPM: 97.8
2053 Male, age 18, unknown 121.2
2140 Male, age 76, both hemispheres 98.3
2272 Male, age 74, both hemispheres 73.9
Pretectal area
nTPM: 142.2
1816 Male, age 51, unknown 222.3
2007 Male, age 72, unknown 195.7
1815 Male, age 53, unknown 193.8
1944 Female, age 72, unknown 187.0
1817 Female, age 42, unknown 177.6
2407 Male, age 75, both hemispheres 131.8
2667 Female, age 75, unknown 109.3
2825 Male, age 18, unknown 104.4
2316 Male, age 76, right hemisphere 82.4
2273 Male, age 74, both hemispheres 80.8
2224 Female, age 72, unknown 78.9
Red nucleus
nTPM: 140.1
2588 Male, age 74, left hemisphere 233.7
2584 Male, age 75, left hemisphere 195.3
2503 Female, age 72, unknown 181.3
2725 Female, age 75, unknown 143.0
2785 Male, age 18, unknown 137.7
1821 Female, age 72, unknown 131.8
1865 Male, age 51, unknown 122.8
1904 Male, age 53, unknown 120.1
2769 Male, age 72, unknown 108.0
1954 Female, age 42, unknown 107.3
2227 Male, age 72, unknown 100.9
2823 Male, age 76, right hemisphere 99.5
Substantia nigra
nTPM: 154.4
2665 Male, age 74, both hemispheres 195.6
1916 Female, age 42, unknown 164.6
1851 Male, age 51, unknown 161.9
2583 Male, age 75, right hemisphere 160.6
1889 Female, age 72, unknown 159.9
2590 Female, age 75, unknown 157.2
1941 Male, age 53, unknown 151.6
2699 Male, age 18, unknown 136.0
2409 Female, age 72, unknown 128.8
2241 Male, age 72, unknown 127.7
Superior colliculus
nTPM: 138.9
2664 Male, age 75, both hemispheres 176.7
2261 Male, age 18, unknown 161.4
2668 Female, age 75, unknown 157.3
2087 Female, age 72, unknown 154.8
2587 Male, age 74, left hemisphere 140.5
1796 Male, age 53, unknown 138.3
1995 Male, age 72, unknown 131.6
1913 Female, age 42, unknown 118.6
1839 Male, age 51, unknown 108.7
1895 Male, age 76, right hemisphere 101.1
Ventral tegmental area
nTPM: 111.2
2410 Female, age 72, unknown 130.2
1915 Female, age 42, unknown 121.1
1942 Male, age 51, unknown 110.9
2223 Female, age 72, unknown 105.3
2218 Male, age 76, both hemispheres 101.8
2021 Male, age 53, unknown 97.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 126.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 126.9
Samples: 139

Max nTPM: 298.9
Min nTPM: 35.5
Std nTPM: 49.5
Median nTPM: 112.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 298.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 276.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 248.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 239.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 234.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 233.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 232.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 227.9
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 227.0
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 207.8
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 207.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 195.4
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 195.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 193.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 191.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 189.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 186.3
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 186.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 184.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 181.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 181.1
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 175.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 174.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 174.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 173.1
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 172.9
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 172.6
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 171.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 167.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 166.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 164.2
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 162.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 161.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 161.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 161.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 161.4
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 158.8
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 156.5
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 155.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 154.8
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 153.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 152.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 150.1
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 148.1
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 146.5
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 143.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 141.9
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 139.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 135.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 133.3
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 129.6
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 127.7
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 127.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 126.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 126.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 125.7
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 124.9
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 124.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 123.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 121.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 121.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 119.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 118.9
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 118.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 116.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 114.6
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 114.6
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 114.0
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 113.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 112.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 111.8
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 111.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 110.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 109.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 109.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 108.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 108.7
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 108.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 108.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 105.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 105.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 105.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 104.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 104.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 104.0
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 103.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 102.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 102.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 102.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 101.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 99.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 99.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 98.5
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 97.8
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 97.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 96.3
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 96.2
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 96.1
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 95.8
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 94.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 94.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 93.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 93.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 93.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 92.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 92.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 91.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 90.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 89.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 89.2
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 88.6
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 87.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 86.8
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 86.6
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 86.1
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 82.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 81.0
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 80.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 79.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 78.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 77.2
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 76.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 76.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 75.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 75.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 75.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 73.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 71.6
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 69.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 69.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 68.6
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 67.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 61.2
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 59.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 59.2
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 52.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 51.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 49.1
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 35.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 460.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 460.4
FF:10158-103A5 76 years, female 460.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 239.1
Pig sample Sample description nTPM
Midbrain
nTPM: 226.1
Samples: 4

Max nTPM: 303.7
Min nTPM: 160.3
Sample A Female 230.6
Sample B Female 160.3
Sample C Male 303.7
Sample D Male 209.6
Periaqueductal gray
nTPM: 148.2
Samples: 3

Max nTPM: 166.0
Min nTPM: 133.1
Sample B Female 145.5
Sample C Male 166.0
Sample D Male 133.1
Substantia nigra
nTPM: 196.1
Samples: 4

Max nTPM: 208.1
Min nTPM: 180.6
Sample A Female 207.3
Sample B Female 180.6
Sample C Male 208.1
Sample D Male 188.3
Superior colliculi
nTPM: 239.1
Samples: 4

Max nTPM: 259.5
Min nTPM: 219.1
Sample A Female 219.1
Sample B Female 246.4
Sample C Male 259.5
Sample D Male 231.4

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 157.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 157.2
Samples: 4

Max nTPM: 168.0
Min nTPM: 137.4
Sample A Male 137.4
Sample B Male 157.5
Sample C Female 168.0
Sample D Female 165.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.5
69885696 Antisense, RP_050512_03_C05, Mouse strain C57BL/6J (56 days, male) 2.5

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