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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:725.3 nTPM
HPA:725.3 nTPM
GTEx:758.6 nTPM
FANTOM5:239.2 Scaled Tags Per Million
Pig:367.2 nTPM
Mouse:130.5 nTPM
Allen mouse:0.8 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 725.3
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 699.6
2019 Male, age 18, unknown 730.6
2828 Female, age 72, unknown 729.4
2666 Male, age 74, left hemisphere 708.4
2411 Female, age 72, unknown 706.6
1827 Male, age 72, unknown 697.9
1833 Male, age 53, unknown 693.4
1830 Male, age 51, unknown 689.3
1870 Female, age 42, unknown 688.3
2586 Male, age 75, left hemisphere 688.1
2219 Male, age 76, both hemispheres 664.2
Dorsal raphe nucleus
nTPM: 701.9
2298 Female, age 72, unknown 721.5
2750 Male, age 76, both hemispheres 707.3
1828 Male, age 53, unknown 704.8
2016 Female, age 72, unknown 692.0
2047 Male, age 72, unknown 683.8
Inferior colliculus
nTPM: 683.9
2097 Female, age 72, unknown 708.5
1890 Male, age 53, unknown 694.8
1848 Female, age 42, unknown 674.8
2849 Male, age 72, unknown 657.2
Median raphe nucleus
nTPM: 695.1
2220 Male, age 76, midline 695.1
Pedunculopontine tegmental nucleus
nTPM: 700.5
2338 Male, age 61, both hemispheres 716.8
2334 Male, age 80, both hemispheres 700.0
1921 Female, age 85, both hemispheres 684.7
Periaquaductal grey, anterior
nTPM: 684.9
1795 Male, age 51, unknown 689.6
2502 Female, age 75, unknown 686.7
1947 Male, age 18, unknown 678.3
Periaquaductal grey, dorsal
nTPM: 676.2
1831 Male, age 72, unknown 690.3
2464 Female, age 72, unknown 679.9
1840 Male, age 53, unknown 671.8
2850 Male, age 76, both hemispheres 662.7
Periaquaductal grey, lateral
nTPM: 680.4
2140 Male, age 76, both hemispheres 688.0
2272 Male, age 74, both hemispheres 682.5
2053 Male, age 18, unknown 670.7
Pretectal area
nTPM: 696.7
1817 Female, age 42, unknown 724.7
1815 Male, age 53, unknown 710.7
2007 Male, age 72, unknown 709.6
1816 Male, age 51, unknown 705.6
2667 Female, age 75, unknown 704.1
1944 Female, age 72, unknown 702.2
2273 Male, age 74, both hemispheres 695.5
2316 Male, age 76, right hemisphere 692.5
2224 Female, age 72, unknown 680.9
2825 Male, age 18, unknown 675.3
2407 Male, age 75, both hemispheres 662.3
Red nucleus
nTPM: 725.3
2503 Female, age 72, unknown 751.3
2227 Male, age 72, unknown 741.9
1821 Female, age 72, unknown 739.9
1865 Male, age 51, unknown 731.8
2769 Male, age 72, unknown 731.4
1904 Male, age 53, unknown 728.3
1954 Female, age 42, unknown 727.2
2785 Male, age 18, unknown 726.6
2588 Male, age 74, left hemisphere 721.3
2823 Male, age 76, right hemisphere 719.0
2725 Female, age 75, unknown 718.9
2584 Male, age 75, left hemisphere 666.3
Substantia nigra
nTPM: 714.1
1916 Female, age 42, unknown 774.4
1851 Male, age 51, unknown 738.5
2699 Male, age 18, unknown 728.1
1889 Female, age 72, unknown 718.4
2665 Male, age 74, both hemispheres 703.3
1941 Male, age 53, unknown 701.8
2583 Male, age 75, right hemisphere 701.3
2241 Male, age 72, unknown 695.3
2590 Female, age 75, unknown 694.9
2409 Female, age 72, unknown 685.4
Superior colliculus
nTPM: 697.3
2087 Female, age 72, unknown 716.5
1995 Male, age 72, unknown 713.3
1913 Female, age 42, unknown 712.1
2668 Female, age 75, unknown 706.2
2587 Male, age 74, left hemisphere 702.8
1796 Male, age 53, unknown 698.1
2261 Male, age 18, unknown 693.2
1839 Male, age 51, unknown 680.0
1895 Male, age 76, right hemisphere 678.7
2664 Male, age 75, both hemispheres 671.9
Ventral tegmental area
nTPM: 709.1
1915 Female, age 42, unknown 734.9
2410 Female, age 72, unknown 730.9
2218 Male, age 76, both hemispheres 705.6
2223 Female, age 72, unknown 702.6
1942 Male, age 51, unknown 691.1
2021 Male, age 53, unknown 689.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 758.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 758.6
Samples: 139

Max nTPM: 1969.7
Min nTPM: 219.9
Std nTPM: 233.7
Median nTPM: 728.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 1969.7
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1372.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 1361.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 1356.4
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 1345.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 1242.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 1196.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 1184.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1156.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1137.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 1134.2
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 1131.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 1113.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 1113.4
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1053.8
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1019.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1019.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 993.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 971.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 969.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 947.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 940.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 917.1
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 908.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 893.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 890.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 888.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 880.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 877.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 873.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 873.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 862.3
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 844.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 836.3
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 833.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 832.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 829.0
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 825.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 822.9
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 822.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 820.6
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 813.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 810.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 809.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 802.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 798.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 794.6
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 794.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 788.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 788.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 786.7
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 785.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 782.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 781.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 779.0
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 777.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 772.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 771.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 770.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 768.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 764.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 764.3
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 764.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 759.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 759.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 749.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 740.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 735.7
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 730.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 728.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 727.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 727.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 727.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 722.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 713.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 711.9
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 703.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 702.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 697.1
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 689.0
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 686.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 686.1
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 684.7
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 681.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 679.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 675.1
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 669.7
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 669.5
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 668.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 665.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 664.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 659.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 654.3
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 647.7
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 645.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 644.0
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 641.6
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 637.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 635.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 628.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 626.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 622.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 615.2
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 613.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 610.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 607.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 607.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 605.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 602.1
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 598.9
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 595.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 584.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 584.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 583.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 581.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 568.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 561.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 560.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 549.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 531.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 526.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 522.4
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 518.9
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 516.7
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 516.6
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 514.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 494.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 492.5
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 489.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 485.3
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 472.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 458.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 444.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 429.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 426.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 409.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 409.0
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 407.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 219.9
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 239.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 239.2
FF:10158-103A5 76 years, female 239.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 367.2
Pig sample Sample description nTPM
Midbrain
nTPM: 316.5
Samples: 4

Max nTPM: 490.2
Min nTPM: 204.4
Sample A Female 490.2
Sample B Female 293.4
Sample C Male 277.9
Sample D Male 204.4
Periaqueductal gray
nTPM: 238.9
Samples: 3

Max nTPM: 255.4
Min nTPM: 218.8
Sample B Female 242.6
Sample C Male 255.4
Sample D Male 218.8
Substantia nigra
nTPM: 315.4
Samples: 4

Max nTPM: 410.2
Min nTPM: 256.3
Sample A Female 410.2
Sample B Female 319.1
Sample C Male 256.3
Sample D Male 276.0
Superior colliculi
nTPM: 367.2
Samples: 4

Max nTPM: 501.7
Min nTPM: 252.9
Sample A Female 403.2
Sample B Female 501.7
Sample C Male 310.9
Sample D Male 252.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 130.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 130.5
Samples: 4

Max nTPM: 149.7
Min nTPM: 118.4
Sample A Male 149.7
Sample B Male 118.5
Sample C Female 118.4
Sample D Female 135.5

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.8
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.8
69873558 Antisense, RP_050512_01_E06, Mouse strain C57BL/6J (56 days, male) 0.8

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