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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:1192.8 nTPM
HPA:1192.8 nTPM
GTEx:1151.3 nTPM
FANTOM5:1165.0 Scaled Tags Per Million
Pig:2.8 nTPM
Mouse:1700.8 nTPM
Allen mouse:15.4 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 1192.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 1119.5
2019 Male, age 18, unknown 1223.1
1870 Female, age 42, unknown 1176.6
2411 Female, age 72, unknown 1171.9
1827 Male, age 72, unknown 1150.2
1833 Male, age 53, unknown 1111.1
1830 Male, age 51, unknown 1097.0
2828 Female, age 72, unknown 1085.4
2219 Male, age 76, both hemispheres 1075.5
2666 Male, age 74, left hemisphere 1066.0
2586 Male, age 75, left hemisphere 1038.3
Dorsal raphe nucleus
nTPM: 1115.9
2750 Male, age 76, both hemispheres 1151.5
2298 Female, age 72, unknown 1147.2
1828 Male, age 53, unknown 1121.7
2047 Male, age 72, unknown 1093.6
2016 Female, age 72, unknown 1065.7
Inferior colliculus
nTPM: 1110.8
2097 Female, age 72, unknown 1175.1
1848 Female, age 42, unknown 1103.1
1890 Male, age 53, unknown 1100.6
2849 Male, age 72, unknown 1064.6
Median raphe nucleus
nTPM: 1109.2
2220 Male, age 76, midline 1109.2
Pedunculopontine tegmental nucleus
nTPM: 1145.2
2334 Male, age 80, both hemispheres 1157.6
1921 Female, age 85, both hemispheres 1150.5
2338 Male, age 61, both hemispheres 1127.7
Periaquaductal grey, anterior
nTPM: 1136.4
1947 Male, age 18, unknown 1147.9
2502 Female, age 75, unknown 1142.3
1795 Male, age 51, unknown 1118.9
Periaquaductal grey, dorsal
nTPM: 1091.4
2464 Female, age 72, unknown 1098.3
1831 Male, age 72, unknown 1097.1
1840 Male, age 53, unknown 1088.0
2850 Male, age 76, both hemispheres 1082.5
Periaquaductal grey, lateral
nTPM: 1095.1
2053 Male, age 18, unknown 1119.4
2272 Male, age 74, both hemispheres 1106.7
2140 Male, age 76, both hemispheres 1059.3
Pretectal area
nTPM: 1192.8
1944 Female, age 72, unknown 1323.6
2007 Male, age 72, unknown 1288.9
1817 Female, age 42, unknown 1282.9
1816 Male, age 51, unknown 1275.2
1815 Male, age 53, unknown 1231.5
2667 Female, age 75, unknown 1176.9
2224 Female, age 72, unknown 1138.1
2273 Male, age 74, both hemispheres 1130.7
2825 Male, age 18, unknown 1094.6
2316 Male, age 76, right hemisphere 1092.6
2407 Male, age 75, both hemispheres 1086.3
Red nucleus
nTPM: 1147.7
1821 Female, age 72, unknown 1245.8
2785 Male, age 18, unknown 1199.9
1865 Male, age 51, unknown 1169.1
1954 Female, age 42, unknown 1160.9
2823 Male, age 76, right hemisphere 1160.3
2725 Female, age 75, unknown 1156.8
2503 Female, age 72, unknown 1148.1
1904 Male, age 53, unknown 1138.1
2588 Male, age 74, left hemisphere 1102.3
2769 Male, age 72, unknown 1101.1
2227 Male, age 72, unknown 1097.9
2584 Male, age 75, left hemisphere 1092.6
Substantia nigra
nTPM: 1134.7
1889 Female, age 72, unknown 1230.5
2241 Male, age 72, unknown 1183.5
2590 Female, age 75, unknown 1154.6
1941 Male, age 53, unknown 1143.4
1851 Male, age 51, unknown 1136.7
1916 Female, age 42, unknown 1134.9
2409 Female, age 72, unknown 1127.5
2583 Male, age 75, right hemisphere 1116.4
2665 Male, age 74, both hemispheres 1090.0
2699 Male, age 18, unknown 1029.9
Superior colliculus
nTPM: 1137.4
2087 Female, age 72, unknown 1201.9
1913 Female, age 42, unknown 1185.8
2587 Male, age 74, left hemisphere 1178.9
1895 Male, age 76, right hemisphere 1164.5
2261 Male, age 18, unknown 1159.2
1995 Male, age 72, unknown 1130.4
1796 Male, age 53, unknown 1113.5
2668 Female, age 75, unknown 1099.2
1839 Male, age 51, unknown 1089.4
2664 Male, age 75, both hemispheres 1050.8
Ventral tegmental area
nTPM: 1105.1
2410 Female, age 72, unknown 1146.3
2223 Female, age 72, unknown 1106.5
2218 Male, age 76, both hemispheres 1099.2
1915 Female, age 42, unknown 1098.7
1942 Male, age 51, unknown 1091.1
2021 Male, age 53, unknown 1088.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1151.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 1151.3
Samples: 139

Max nTPM: 1773.9
Min nTPM: 688.8
Std nTPM: 223.2
Median nTPM: 1110.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 1773.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1768.2
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 1744.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 1719.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1669.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 1630.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1600.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 1598.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 1536.7
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 1533.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 1529.4
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 1506.8
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 1497.9
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 1474.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 1469.6
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 1460.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 1454.3
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 1428.2
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 1413.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 1404.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 1398.6
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 1366.5
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 1366.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 1357.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 1357.8
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 1352.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 1350.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 1344.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 1335.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 1321.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 1315.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 1304.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 1288.5
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1287.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 1285.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 1275.3
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 1255.0
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 1254.3
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 1244.9
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 1238.0
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 1232.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 1222.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 1219.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 1216.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 1214.1
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 1209.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 1198.8
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 1185.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 1184.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 1183.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 1183.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 1179.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 1179.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 1171.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 1170.0
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 1165.1
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 1164.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 1161.7
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 1158.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1147.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 1147.0
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 1146.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 1144.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 1139.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 1131.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 1127.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 1120.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 1113.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1112.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 1110.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 1105.2
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 1101.0
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 1098.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 1096.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 1092.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1092.5
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 1087.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 1079.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 1079.1
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 1078.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 1074.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 1070.4
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 1069.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1062.0
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 1058.9
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 1056.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 1052.2
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 1050.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 1047.9
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 1046.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 1037.2
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 1031.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 1030.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 1028.2
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 1027.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 1021.1
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 1019.0
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 1009.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 1009.1
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 1007.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 1001.9
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 999.3
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 997.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 994.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 990.8
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 990.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 989.7
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 982.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 981.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 980.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 980.0
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 973.7
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 971.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 966.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 966.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 965.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 964.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 960.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 956.6
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 949.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 937.3
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 929.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 927.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 916.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 910.9
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 909.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 903.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 888.7
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 879.0
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 846.6
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 832.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 821.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 820.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 818.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 815.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 802.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 795.9
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 752.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 688.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 1165.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 1165.0
FF:10158-103A5 76 years, female 1165.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 2.8
Pig sample Sample description nTPM
Midbrain
nTPM: 1.7
Samples: 4

Max nTPM: 2.1
Min nTPM: 0.8
Sample A Female 0.8
Sample B Female 1.9
Sample C Male 2.1
Sample D Male 1.9
Periaqueductal gray
nTPM: 2.8
Samples: 3

Max nTPM: 3.4
Min nTPM: 2.4
Sample B Female 2.4
Sample C Male 3.4
Sample D Male 2.5
Substantia nigra
nTPM: 1.6
Samples: 4

Max nTPM: 2.5
Min nTPM: 0.7
Sample A Female 0.7
Sample B Female 1.5
Sample C Male 1.8
Sample D Male 2.5
Superior colliculi
nTPM: 1.6
Samples: 4

Max nTPM: 2.2
Min nTPM: 0.5
Sample A Female 0.5
Sample B Female 2.2
Sample C Male 2.2
Sample D Male 1.4

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1700.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 1700.8
Samples: 4

Max nTPM: 1730.7
Min nTPM: 1664.4
Sample A Male 1716.9
Sample B Male 1730.7
Sample C Female 1691.3
Sample D Female 1664.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 15.4
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 15.4
182 Antisense, RP_Baylor_102653, Mouse strain C57BL/6J (56 days, male) 15.4
183 Antisense, RP_Baylor_102653, Mouse strain C57BL/6J (56 days, male) 14.6

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.