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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:143.6 nTPM
HPA:143.6 nTPM
GTEx:219.3 nTPM
FANTOM5:96.3 Scaled Tags Per Million
Pig:17.7 nTPM
Mouse:781.8 nTPM
Allen mouse:12.3 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 143.6
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 135.1
2019 Male, age 18, unknown 154.0
2411 Female, age 72, unknown 147.3
1827 Male, age 72, unknown 141.5
2828 Female, age 72, unknown 134.6
1870 Female, age 42, unknown 132.7
2219 Male, age 76, both hemispheres 131.4
1833 Male, age 53, unknown 129.7
1830 Male, age 51, unknown 126.9
2666 Male, age 74, left hemisphere 126.6
2586 Male, age 75, left hemisphere 126.2
Dorsal raphe nucleus
nTPM: 141.5
2298 Female, age 72, unknown 158.6
1828 Male, age 53, unknown 145.0
2047 Male, age 72, unknown 140.8
2750 Male, age 76, both hemispheres 134.6
2016 Female, age 72, unknown 128.2
Inferior colliculus
nTPM: 138.8
2097 Female, age 72, unknown 158.1
1890 Male, age 53, unknown 140.7
1848 Female, age 42, unknown 132.9
2849 Male, age 72, unknown 123.5
Median raphe nucleus
nTPM: 130.3
2220 Male, age 76, midline 130.3
Pedunculopontine tegmental nucleus
nTPM: 135.7
1921 Female, age 85, both hemispheres 142.4
2334 Male, age 80, both hemispheres 136.3
2338 Male, age 61, both hemispheres 128.3
Periaquaductal grey, anterior
nTPM: 133.6
1947 Male, age 18, unknown 134.9
1795 Male, age 51, unknown 133.1
2502 Female, age 75, unknown 132.8
Periaquaductal grey, dorsal
nTPM: 128.2
1840 Male, age 53, unknown 130.4
1831 Male, age 72, unknown 129.5
2464 Female, age 72, unknown 129.4
2850 Male, age 76, both hemispheres 123.2
Periaquaductal grey, lateral
nTPM: 127.5
2272 Male, age 74, both hemispheres 129.9
2053 Male, age 18, unknown 128.9
2140 Male, age 76, both hemispheres 123.7
Pretectal area
nTPM: 143.6
2007 Male, age 72, unknown 163.6
1816 Male, age 51, unknown 156.6
1944 Female, age 72, unknown 155.4
1817 Female, age 42, unknown 155.1
2667 Female, age 75, unknown 145.5
1815 Male, age 53, unknown 144.6
2273 Male, age 74, both hemispheres 138.3
2224 Female, age 72, unknown 135.5
2316 Male, age 76, right hemisphere 131.1
2407 Male, age 75, both hemispheres 127.0
2825 Male, age 18, unknown 126.9
Red nucleus
nTPM: 134.9
1821 Female, age 72, unknown 151.1
2785 Male, age 18, unknown 140.3
2725 Female, age 75, unknown 139.0
2823 Male, age 76, right hemisphere 137.0
2503 Female, age 72, unknown 136.0
1865 Male, age 51, unknown 132.4
2769 Male, age 72, unknown 132.1
2588 Male, age 74, left hemisphere 132.0
1954 Female, age 42, unknown 131.7
2227 Male, age 72, unknown 131.0
1904 Male, age 53, unknown 129.0
2584 Male, age 75, left hemisphere 126.7
Substantia nigra
nTPM: 143.3
1889 Female, age 72, unknown 157.9
1916 Female, age 42, unknown 155.7
1851 Male, age 51, unknown 152.0
1941 Male, age 53, unknown 151.6
2241 Male, age 72, unknown 147.7
2409 Female, age 72, unknown 138.9
2665 Male, age 74, both hemispheres 138.8
2590 Female, age 75, unknown 131.6
2699 Male, age 18, unknown 129.7
2583 Male, age 75, right hemisphere 128.6
Superior colliculus
nTPM: 134.2
2087 Female, age 72, unknown 148.1
1895 Male, age 76, right hemisphere 141.1
2668 Female, age 75, unknown 137.0
2261 Male, age 18, unknown 136.0
2587 Male, age 74, left hemisphere 134.7
1796 Male, age 53, unknown 133.8
1839 Male, age 51, unknown 129.4
1913 Female, age 42, unknown 128.7
1995 Male, age 72, unknown 127.7
2664 Male, age 75, both hemispheres 125.7
Ventral tegmental area
nTPM: 138.3
2410 Female, age 72, unknown 156.0
1915 Female, age 42, unknown 145.8
2218 Male, age 76, both hemispheres 137.7
1942 Male, age 51, unknown 134.5
2021 Male, age 53, unknown 128.2
2223 Female, age 72, unknown 127.5

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 219.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 219.3
Samples: 139

Max nTPM: 608.9
Min nTPM: 101.5
Std nTPM: 79.0
Median nTPM: 200.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 608.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 476.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 431.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 421.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 401.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 398.9
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 393.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 387.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 356.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 329.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 324.3
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 322.0
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 320.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 319.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 318.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 312.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 307.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 307.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 305.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 305.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 305.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 288.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 285.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 282.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 276.7
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 276.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 273.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 264.1
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 262.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 259.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 259.0
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 254.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 249.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 249.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 249.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 247.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 244.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 244.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 241.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 240.1
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 238.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 238.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 237.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 234.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 230.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 230.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 230.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 230.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 229.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 227.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 227.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 227.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 226.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 225.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 225.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 223.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 220.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 220.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 218.8
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 218.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 214.7
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 214.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 213.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 212.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 212.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 210.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 209.9
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 209.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 207.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 200.8
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 200.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 198.9
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 198.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 196.5
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 195.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 195.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 194.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 193.6
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 192.6
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 192.6
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 191.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 191.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 189.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 188.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 187.1
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 186.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 185.7
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 185.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 183.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 183.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 183.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 181.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 181.3
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 181.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 180.8
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 179.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 179.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 178.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 177.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 177.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 174.5
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 174.0
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 173.1
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 172.4
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 169.3
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 167.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 166.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 165.4
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 164.2
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 161.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 159.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 152.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 151.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 151.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 151.2
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 146.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 146.3
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 144.3
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 144.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 141.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 141.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 139.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 139.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 137.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 134.5
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 134.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 133.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 133.0
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 132.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 132.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 124.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 123.8
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 123.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 120.2
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 119.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 114.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 112.8
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 111.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 101.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 96.3
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 96.3
FF:10158-103A5 76 years, female 96.3

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 17.7
Pig sample Sample description nTPM
Midbrain
nTPM: 14.3
Samples: 4

Max nTPM: 16.5
Min nTPM: 12.5
Sample A Female 12.5
Sample B Female 12.6
Sample C Male 16.5
Sample D Male 15.6
Periaqueductal gray
nTPM: 12.0
Samples: 3

Max nTPM: 13.2
Min nTPM: 10.9
Sample B Female 11.8
Sample C Male 13.2
Sample D Male 10.9
Substantia nigra
nTPM: 12.9
Samples: 4

Max nTPM: 16.9
Min nTPM: 10.3
Sample A Female 16.9
Sample B Female 10.8
Sample C Male 13.6
Sample D Male 10.3
Superior colliculi
nTPM: 17.7
Samples: 4

Max nTPM: 20.4
Min nTPM: 13.8
Sample A Female 20.2
Sample B Female 16.4
Sample C Male 20.4
Sample D Male 13.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 781.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 781.8
Samples: 4

Max nTPM: 836.1
Min nTPM: 717.2
Sample A Male 836.1
Sample B Male 795.7
Sample C Female 717.2
Sample D Female 778.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 12.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 12.3
69526970 Antisense, RP_050421_02_A07, Mouse strain C57BL/6J (56 days, male) 12.3

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