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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:53.1 nTPM
HPA:53.1 nTPM
GTEx:159.8 nTPM
FANTOM5:379.2 Scaled Tags Per Million
Pig:51.0 nTPM
Mouse:23.8 nTPM
Allen mouse:15.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 53.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 47.0
1830 Male, age 51, unknown 55.8
1833 Male, age 53, unknown 52.3
2666 Male, age 74, left hemisphere 50.3
2586 Male, age 75, left hemisphere 49.2
2219 Male, age 76, both hemispheres 48.9
2828 Female, age 72, unknown 47.6
2019 Male, age 18, unknown 44.0
1870 Female, age 42, unknown 41.6
2411 Female, age 72, unknown 41.1
1827 Male, age 72, unknown 39.4
Dorsal raphe nucleus
nTPM: 37.4
2750 Male, age 76, both hemispheres 44.4
2016 Female, age 72, unknown 37.8
1828 Male, age 53, unknown 36.5
2047 Male, age 72, unknown 35.1
2298 Female, age 72, unknown 33.2
Inferior colliculus
nTPM: 39.0
2849 Male, age 72, unknown 53.9
1890 Male, age 53, unknown 38.7
1848 Female, age 42, unknown 33.8
2097 Female, age 72, unknown 29.6
Median raphe nucleus
nTPM: 45.6
2220 Male, age 76, midline 45.6
Pedunculopontine tegmental nucleus
nTPM: 46.5
2338 Male, age 61, both hemispheres 57.1
2334 Male, age 80, both hemispheres 43.8
1921 Female, age 85, both hemispheres 38.5
Periaquaductal grey, anterior
nTPM: 36.8
1795 Male, age 51, unknown 38.2
1947 Male, age 18, unknown 36.5
2502 Female, age 75, unknown 35.6
Periaquaductal grey, dorsal
nTPM: 44.9
2850 Male, age 76, both hemispheres 55.9
1831 Male, age 72, unknown 46.4
2464 Female, age 72, unknown 44.2
1840 Male, age 53, unknown 33.0
Periaquaductal grey, lateral
nTPM: 53.1
2272 Male, age 74, both hemispheres 59.4
2140 Male, age 76, both hemispheres 55.1
2053 Male, age 18, unknown 44.7
Pretectal area
nTPM: 42.2
2407 Male, age 75, both hemispheres 57.0
2316 Male, age 76, right hemisphere 56.9
2667 Female, age 75, unknown 47.6
2273 Male, age 74, both hemispheres 45.7
2825 Male, age 18, unknown 43.2
1815 Male, age 53, unknown 41.9
2224 Female, age 72, unknown 39.8
1816 Male, age 51, unknown 35.6
1944 Female, age 72, unknown 34.2
2007 Male, age 72, unknown 32.2
1817 Female, age 42, unknown 30.3
Red nucleus
nTPM: 50.6
2823 Male, age 76, right hemisphere 61.4
2769 Male, age 72, unknown 58.4
2588 Male, age 74, left hemisphere 57.4
1904 Male, age 53, unknown 56.2
2584 Male, age 75, left hemisphere 55.7
2227 Male, age 72, unknown 55.2
1865 Male, age 51, unknown 55.1
2785 Male, age 18, unknown 50.4
2503 Female, age 72, unknown 43.6
2725 Female, age 75, unknown 41.7
1954 Female, age 42, unknown 38.4
1821 Female, age 72, unknown 33.8
Substantia nigra
nTPM: 40.3
2699 Male, age 18, unknown 55.4
2583 Male, age 75, right hemisphere 51.2
2590 Female, age 75, unknown 48.7
2665 Male, age 74, both hemispheres 46.7
1941 Male, age 53, unknown 39.2
1851 Male, age 51, unknown 37.7
2409 Female, age 72, unknown 35.3
1889 Female, age 72, unknown 32.9
1916 Female, age 42, unknown 30.1
2241 Male, age 72, unknown 26.2
Superior colliculus
nTPM: 45.2
1913 Female, age 42, unknown 66.0
1995 Male, age 72, unknown 55.3
2664 Male, age 75, both hemispheres 46.6
1895 Male, age 76, right hemisphere 45.1
1839 Male, age 51, unknown 42.9
2087 Female, age 72, unknown 41.8
1796 Male, age 53, unknown 39.4
2587 Male, age 74, left hemisphere 39.0
2668 Female, age 75, unknown 38.6
2261 Male, age 18, unknown 37.8
Ventral tegmental area
nTPM: 41.1
2021 Male, age 53, unknown 48.5
2223 Female, age 72, unknown 45.3
2218 Male, age 76, both hemispheres 42.9
2410 Female, age 72, unknown 38.2
1942 Male, age 51, unknown 37.3
1915 Female, age 42, unknown 34.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 159.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 159.8
Samples: 139

Max nTPM: 468.9
Min nTPM: 52.5
Std nTPM: 59.5
Median nTPM: 161.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 468.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 323.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 316.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 293.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 290.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 290.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 281.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 252.2
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 245.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 231.8
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 228.1
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 225.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 223.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 216.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 216.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 212.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 208.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 207.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 207.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 206.4
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 205.1
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 204.9
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 204.5
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 204.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 203.2
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 203.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 202.0
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 201.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 200.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 197.9
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 197.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 197.5
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 197.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 195.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 194.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 193.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 192.7
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 190.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 189.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 188.5
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 184.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 183.1
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 182.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 181.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 178.6
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 178.0
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 177.8
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 177.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 174.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 174.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 173.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 173.6
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 173.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 172.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 171.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 171.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 168.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 168.3
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 168.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 167.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 167.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 167.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 166.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 166.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 165.7
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 163.0
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 162.3
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 161.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 161.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 161.2
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 160.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 158.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 154.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 152.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 150.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 149.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 149.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 148.4
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 146.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 146.2
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 145.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 144.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 143.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 142.9
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 138.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 138.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 138.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 137.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 136.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 135.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 134.2
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 131.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 131.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 130.7
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 129.2
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 128.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 127.2
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 125.3
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 124.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 123.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 123.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 122.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 121.6
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 119.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 119.4
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 117.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 115.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 115.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 115.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 114.5
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 114.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 112.2
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 110.2
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 109.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 108.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 108.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 107.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 107.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 106.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 106.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 101.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 101.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 100.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 99.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 95.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 90.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 89.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 89.4
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 88.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 78.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 77.0
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 69.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 63.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 59.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 56.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 56.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 56.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 55.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 52.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 379.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 379.2
FF:10158-103A5 76 years, female 379.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 51.0
Pig sample Sample description nTPM
Midbrain
nTPM: 39.2
Samples: 4

Max nTPM: 48.9
Min nTPM: 31.3
Sample A Female 34.2
Sample B Female 48.9
Sample C Male 31.3
Sample D Male 42.2
Periaqueductal gray
nTPM: 41.6
Samples: 3

Max nTPM: 48.8
Min nTPM: 36.9
Sample B Female 39.0
Sample C Male 36.9
Sample D Male 48.8
Substantia nigra
nTPM: 51.0
Samples: 4

Max nTPM: 83.4
Min nTPM: 23.7
Sample A Female 23.7
Sample B Female 51.8
Sample C Male 44.9
Sample D Male 83.4
Superior colliculi
nTPM: 37.5
Samples: 4

Max nTPM: 50.8
Min nTPM: 26.9
Sample A Female 26.9
Sample B Female 37.8
Sample C Male 34.4
Sample D Male 50.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 23.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 23.8
Samples: 4

Max nTPM: 33.7
Min nTPM: 19.2
Sample A Male 33.7
Sample B Male 21.6
Sample C Female 20.6
Sample D Female 19.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 15.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 15.0
77620457 Antisense, RP_070129_03_D05, Mouse strain C57BL/6J (56 days, male) 15.0

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