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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:790.0 nTPM
HPA:790.0 nTPM
GTEx:862.3 nTPM
FANTOM5:328.4 Scaled Tags Per Million
Pig:9.1 nTPM
Mouse:223.6 nTPM
Allen mouse:15.5 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 790.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 769.4
2828 Female, age 72, unknown 791.5
1870 Female, age 42, unknown 783.6
2411 Female, age 72, unknown 782.8
1827 Male, age 72, unknown 777.6
1833 Male, age 53, unknown 775.0
1830 Male, age 51, unknown 771.1
2666 Male, age 74, left hemisphere 766.7
2019 Male, age 18, unknown 763.6
2586 Male, age 75, left hemisphere 751.0
2219 Male, age 76, both hemispheres 730.6
Dorsal raphe nucleus
nTPM: 782.7
2298 Female, age 72, unknown 809.3
2750 Male, age 76, both hemispheres 785.6
1828 Male, age 53, unknown 779.1
2016 Female, age 72, unknown 772.5
2047 Male, age 72, unknown 766.7
Inferior colliculus
nTPM: 763.3
2097 Female, age 72, unknown 785.3
1890 Male, age 53, unknown 758.9
2849 Male, age 72, unknown 756.1
1848 Female, age 42, unknown 752.8
Median raphe nucleus
nTPM: 790.0
2220 Male, age 76, midline 790.0
Pedunculopontine tegmental nucleus
nTPM: 784.3
2338 Male, age 61, both hemispheres 797.2
2334 Male, age 80, both hemispheres 785.0
1921 Female, age 85, both hemispheres 770.6
Periaquaductal grey, anterior
nTPM: 760.5
1947 Male, age 18, unknown 768.4
1795 Male, age 51, unknown 759.2
2502 Female, age 75, unknown 754.0
Periaquaductal grey, dorsal
nTPM: 761.2
2850 Male, age 76, both hemispheres 774.7
1840 Male, age 53, unknown 765.3
1831 Male, age 72, unknown 759.8
2464 Female, age 72, unknown 744.8
Periaquaductal grey, lateral
nTPM: 762.5
2053 Male, age 18, unknown 766.2
2140 Male, age 76, both hemispheres 761.2
2272 Male, age 74, both hemispheres 760.0
Pretectal area
nTPM: 773.8
1817 Female, age 42, unknown 791.4
2667 Female, age 75, unknown 788.9
1815 Male, age 53, unknown 783.3
2273 Male, age 74, both hemispheres 778.9
1816 Male, age 51, unknown 777.3
2224 Female, age 72, unknown 775.9
2825 Male, age 18, unknown 771.3
2007 Male, age 72, unknown 769.8
1944 Female, age 72, unknown 768.9
2316 Male, age 76, right hemisphere 758.8
2407 Male, age 75, both hemispheres 747.2
Red nucleus
nTPM: 775.0
1821 Female, age 72, unknown 821.2
2503 Female, age 72, unknown 790.5
2823 Male, age 76, right hemisphere 788.7
1904 Male, age 53, unknown 785.2
2227 Male, age 72, unknown 778.7
1865 Male, age 51, unknown 778.2
1954 Female, age 42, unknown 776.9
2769 Male, age 72, unknown 775.4
2725 Female, age 75, unknown 766.7
2785 Male, age 18, unknown 766.2
2588 Male, age 74, left hemisphere 744.9
2584 Male, age 75, left hemisphere 727.1
Substantia nigra
nTPM: 780.7
1916 Female, age 42, unknown 814.0
2699 Male, age 18, unknown 795.8
1851 Male, age 51, unknown 795.2
1889 Female, age 72, unknown 786.6
2241 Male, age 72, unknown 785.0
2665 Male, age 74, both hemispheres 782.7
2409 Female, age 72, unknown 766.6
1941 Male, age 53, unknown 766.3
2590 Female, age 75, unknown 763.9
2583 Male, age 75, right hemisphere 751.3
Superior colliculus
nTPM: 771.2
2587 Male, age 74, left hemisphere 791.4
2668 Female, age 75, unknown 786.4
1913 Female, age 42, unknown 785.8
1995 Male, age 72, unknown 776.9
1796 Male, age 53, unknown 770.9
2087 Female, age 72, unknown 768.0
2261 Male, age 18, unknown 758.8
1839 Male, age 51, unknown 758.4
1895 Male, age 76, right hemisphere 757.7
2664 Male, age 75, both hemispheres 757.6
Ventral tegmental area
nTPM: 785.2
1915 Female, age 42, unknown 806.6
2410 Female, age 72, unknown 800.9
2218 Male, age 76, both hemispheres 782.9
2223 Female, age 72, unknown 775.0
1942 Male, age 51, unknown 773.2
2021 Male, age 53, unknown 772.5

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 862.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 862.3
Samples: 139

Max nTPM: 1632.1
Min nTPM: 533.2
Std nTPM: 178.4
Median nTPM: 843.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 1632.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1474.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1380.0
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 1310.7
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 1298.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 1198.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 1179.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 1154.8
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 1143.7
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 1140.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 1107.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 1091.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 1091.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 1081.0
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 1078.7
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1075.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1066.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 1057.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1037.8
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 1028.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 1017.0
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 1006.5
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 1005.0
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 1002.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 992.8
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 990.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 980.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 978.8
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 975.2
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 972.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 970.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 970.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 967.9
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 967.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 961.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 961.2
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 949.8
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 948.9
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 941.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 931.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 929.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 925.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 920.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 919.3
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 917.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 915.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 909.9
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 905.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 904.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 901.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 901.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 900.9
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 892.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 889.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 888.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 886.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 883.5
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 873.3
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 872.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 870.3
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 868.8
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 866.8
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 865.2
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 861.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 860.4
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 849.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 849.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 844.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 843.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 843.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 843.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 836.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 830.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 828.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 828.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 827.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 822.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 805.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 803.2
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 801.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 799.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 798.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 798.6
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 790.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 789.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 789.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 780.5
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 774.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 774.6
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 771.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 771.6
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 764.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 763.1
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 756.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 756.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 754.0
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 750.5
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 749.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 747.5
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 746.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 746.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 746.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 738.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 737.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 730.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 729.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 726.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 725.9
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 724.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 722.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 721.6
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 720.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 718.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 718.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 717.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 714.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 710.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 707.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 703.7
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 696.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 687.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 684.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 679.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 679.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 671.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 665.1
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 664.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 657.9
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 657.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 656.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 647.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 646.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 616.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 611.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 589.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 585.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 582.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 547.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 533.2
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 328.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 328.4
FF:10158-103A5 76 years, female 328.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 9.1
Pig sample Sample description nTPM
Midbrain
nTPM: 5.8
Samples: 4

Max nTPM: 7.9
Min nTPM: 2.6
Sample A Female 2.6
Sample B Female 7.9
Sample C Male 5.6
Sample D Male 7.1
Periaqueductal gray
nTPM: 7.9
Samples: 3

Max nTPM: 10.5
Min nTPM: 3.4
Sample B Female 9.7
Sample C Male 3.4
Sample D Male 10.5
Substantia nigra
nTPM: 9.1
Samples: 4

Max nTPM: 17.3
Min nTPM: 3.7
Sample A Female 3.7
Sample B Female 7.9
Sample C Male 7.6
Sample D Male 17.3
Superior colliculi
nTPM: 5.4
Samples: 4

Max nTPM: 6.7
Min nTPM: 2.8
Sample A Female 2.8
Sample B Female 5.3
Sample C Male 6.7
Sample D Male 6.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 223.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 223.6
Samples: 4

Max nTPM: 242.4
Min nTPM: 211.4
Sample A Male 242.4
Sample B Male 219.3
Sample C Female 211.4
Sample D Female 221.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 15.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 15.5
2245 Antisense, RP_040420_01_B03, Mouse strain C57BL/6J (56 days, male) 15.5
2246 Antisense, RP_040420_01_B03, Mouse strain C57BL/6J (56 days, male) 15.2

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