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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:158.7 nTPM
HPA:158.7 nTPM
GTEx:127.7 nTPM
FANTOM5:34.4 Scaled Tags Per Million
Pig:67.1 nTPM
Mouse:24.7 nTPM
Allen mouse:0.8 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 158.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 137.0
2586 Male, age 75, left hemisphere 161.7
2828 Female, age 72, unknown 143.8
1870 Female, age 42, unknown 143.5
2666 Male, age 74, left hemisphere 143.4
1827 Male, age 72, unknown 136.8
2411 Female, age 72, unknown 132.2
1833 Male, age 53, unknown 131.8
1830 Male, age 51, unknown 128.9
2219 Male, age 76, both hemispheres 128.5
2019 Male, age 18, unknown 119.9
Dorsal raphe nucleus
nTPM: 158.7
2047 Male, age 72, unknown 185.3
1828 Male, age 53, unknown 174.1
2298 Female, age 72, unknown 151.2
2016 Female, age 72, unknown 142.5
2750 Male, age 76, both hemispheres 140.5
Inferior colliculus
nTPM: 135.2
2849 Male, age 72, unknown 139.5
1890 Male, age 53, unknown 134.5
1848 Female, age 42, unknown 134.3
2097 Female, age 72, unknown 132.6
Median raphe nucleus
nTPM: 150.2
2220 Male, age 76, midline 150.2
Pedunculopontine tegmental nucleus
nTPM: 133.7
2334 Male, age 80, both hemispheres 140.6
1921 Female, age 85, both hemispheres 133.7
2338 Male, age 61, both hemispheres 126.8
Periaquaductal grey, anterior
nTPM: 151.6
1795 Male, age 51, unknown 160.1
1947 Male, age 18, unknown 149.8
2502 Female, age 75, unknown 144.8
Periaquaductal grey, dorsal
nTPM: 143.8
1840 Male, age 53, unknown 154.6
2850 Male, age 76, both hemispheres 144.8
1831 Male, age 72, unknown 141.2
2464 Female, age 72, unknown 134.6
Periaquaductal grey, lateral
nTPM: 141.1
2140 Male, age 76, both hemispheres 144.3
2272 Male, age 74, both hemispheres 142.2
2053 Male, age 18, unknown 136.8
Pretectal area
nTPM: 139.0
2825 Male, age 18, unknown 149.3
2273 Male, age 74, both hemispheres 147.0
1816 Male, age 51, unknown 146.3
1944 Female, age 72, unknown 145.7
2224 Female, age 72, unknown 144.0
2667 Female, age 75, unknown 139.3
1815 Male, age 53, unknown 133.2
2407 Male, age 75, both hemispheres 132.4
2316 Male, age 76, right hemisphere 132.0
2007 Male, age 72, unknown 130.5
1817 Female, age 42, unknown 129.8
Red nucleus
nTPM: 128.4
2725 Female, age 75, unknown 139.6
2584 Male, age 75, left hemisphere 135.7
2588 Male, age 74, left hemisphere 133.1
2227 Male, age 72, unknown 131.6
2503 Female, age 72, unknown 131.2
2769 Male, age 72, unknown 131.0
2785 Male, age 18, unknown 129.8
1904 Male, age 53, unknown 124.3
1954 Female, age 42, unknown 123.5
1821 Female, age 72, unknown 123.1
1865 Male, age 51, unknown 118.9
2823 Male, age 76, right hemisphere 118.5
Substantia nigra
nTPM: 132.3
2665 Male, age 74, both hemispheres 143.8
1851 Male, age 51, unknown 141.9
2699 Male, age 18, unknown 140.0
2583 Male, age 75, right hemisphere 139.3
1916 Female, age 42, unknown 138.6
1889 Female, age 72, unknown 129.4
2590 Female, age 75, unknown 128.1
2241 Male, age 72, unknown 123.2
2409 Female, age 72, unknown 122.3
1941 Male, age 53, unknown 116.6
Superior colliculus
nTPM: 140.3
2664 Male, age 75, both hemispheres 161.6
1796 Male, age 53, unknown 148.6
2087 Female, age 72, unknown 145.7
2261 Male, age 18, unknown 144.1
2587 Male, age 74, left hemisphere 141.2
1839 Male, age 51, unknown 139.6
2668 Female, age 75, unknown 134.7
1913 Female, age 42, unknown 133.3
1995 Male, age 72, unknown 130.0
1895 Male, age 76, right hemisphere 124.8
Ventral tegmental area
nTPM: 145.3
2223 Female, age 72, unknown 158.7
2021 Male, age 53, unknown 154.6
1915 Female, age 42, unknown 152.1
1942 Male, age 51, unknown 140.0
2218 Male, age 76, both hemispheres 134.6
2410 Female, age 72, unknown 132.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 127.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 127.7
Samples: 139

Max nTPM: 282.3
Min nTPM: 23.7
Std nTPM: 46.2
Median nTPM: 118.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 282.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 278.4
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 269.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 259.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 251.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 242.6
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 235.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 228.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 203.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 199.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 191.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 190.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 188.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 188.0
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 185.2
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 182.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 181.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 178.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 178.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 173.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 171.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 162.3
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 160.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 159.3
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 158.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 157.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 157.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 155.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 154.9
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 153.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 152.5
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 152.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 150.6
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 148.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 147.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 146.6
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 145.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 144.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 144.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 144.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 143.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 142.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 142.3
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 141.0
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 140.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 140.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 140.0
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 139.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 139.6
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 136.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 135.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 134.7
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 134.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 133.7
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 133.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 133.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 132.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 132.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 132.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 129.9
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 126.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 125.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 123.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 121.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 121.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 120.6
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 120.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 120.2
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 119.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 118.2
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 118.0
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 117.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 117.1
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 114.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 114.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 114.3
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 113.9
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 113.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 113.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 113.0
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 111.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 111.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 110.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 109.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 108.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 106.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 106.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 106.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 106.0
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 104.9
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 104.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 103.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 103.0
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 102.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 101.7
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 101.3
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 100.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 100.2
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 100.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 99.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 97.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 96.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 96.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 95.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 95.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 95.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 92.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 91.0
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 90.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 90.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 90.4
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 90.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 89.8
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 89.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 89.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 88.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 88.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 87.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 87.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 86.3
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 86.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 86.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 85.7
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 85.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 85.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 83.2
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 83.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 79.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 78.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 76.9
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 76.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 74.9
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 74.7
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 63.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 62.1
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 53.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 53.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 49.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 23.7
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 34.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 34.4
FF:10158-103A5 76 years, female 34.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 67.1
Pig sample Sample description nTPM
Midbrain
nTPM: 53.4
Samples: 4

Max nTPM: 74.0
Min nTPM: 35.6
Sample A Female 74.0
Sample B Female 40.0
Sample C Male 64.0
Sample D Male 35.6
Periaqueductal gray
nTPM: 33.1
Samples: 3

Max nTPM: 45.1
Min nTPM: 25.4
Sample B Female 25.4
Sample C Male 45.1
Sample D Male 28.9
Substantia nigra
nTPM: 67.1
Samples: 4

Max nTPM: 83.6
Min nTPM: 40.7
Sample A Female 83.6
Sample B Female 77.3
Sample C Male 66.9
Sample D Male 40.7
Superior colliculi
nTPM: 59.7
Samples: 4

Max nTPM: 80.9
Min nTPM: 44.0
Sample A Female 59.4
Sample B Female 80.9
Sample C Male 54.5
Sample D Male 44.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 24.7
Mouse sample Sample description nTPM
Midbrain
nTPM: 24.8
Samples: 4

Max nTPM: 29.4
Min nTPM: 19.7
Sample A Male 29.4
Sample B Male 23.1
Sample C Female 19.7
Sample D Female 26.8

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.8
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.8
70612727 Antisense, RP_050725_01_C05, Mouse strain C57BL/6J (56 days, male) 1.3
75695661 Antisense, RP_060518_04_C12, Mouse strain C57BL/6J (56 days, male) 0.3

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