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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:1259.8 nTPM
HPA:1259.8 nTPM
GTEx:1816.7 nTPM
FANTOM5:1616.4 Scaled Tags Per Million
Pig:677.4 nTPM
Mouse:697.2 nTPM
Allen mouse:4.2 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 1259.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 1117.7
1870 Female, age 42, unknown 1212.6
2828 Female, age 72, unknown 1209.6
1830 Male, age 51, unknown 1181.7
1833 Male, age 53, unknown 1169.2
2411 Female, age 72, unknown 1134.9
2666 Male, age 74, left hemisphere 1117.6
2019 Male, age 18, unknown 1079.1
2586 Male, age 75, left hemisphere 1068.6
1827 Male, age 72, unknown 1027.3
2219 Male, age 76, both hemispheres 976.5
Dorsal raphe nucleus
nTPM: 1072.4
2750 Male, age 76, both hemispheres 1249.0
2016 Female, age 72, unknown 1120.8
1828 Male, age 53, unknown 1049.1
2047 Male, age 72, unknown 993.9
2298 Female, age 72, unknown 949.1
Inferior colliculus
nTPM: 993.8
2849 Male, age 72, unknown 1030.4
1890 Male, age 53, unknown 1012.5
1848 Female, age 42, unknown 998.8
2097 Female, age 72, unknown 933.4
Median raphe nucleus
nTPM: 1067.2
2220 Male, age 76, midline 1067.2
Pedunculopontine tegmental nucleus
nTPM: 1030.9
2334 Male, age 80, both hemispheres 1102.0
1921 Female, age 85, both hemispheres 1013.3
2338 Male, age 61, both hemispheres 977.3
Periaquaductal grey, anterior
nTPM: 955.5
2502 Female, age 75, unknown 976.2
1795 Male, age 51, unknown 958.7
1947 Male, age 18, unknown 931.6
Periaquaductal grey, dorsal
nTPM: 993.7
2464 Female, age 72, unknown 1044.3
2850 Male, age 76, both hemispheres 1002.8
1831 Male, age 72, unknown 992.4
1840 Male, age 53, unknown 935.4
Periaquaductal grey, lateral
nTPM: 987.6
2053 Male, age 18, unknown 1064.5
2140 Male, age 76, both hemispheres 963.5
2272 Male, age 74, both hemispheres 934.9
Pretectal area
nTPM: 974.9
2316 Male, age 76, right hemisphere 1077.2
1815 Male, age 53, unknown 1073.0
2825 Male, age 18, unknown 1049.6
1817 Female, age 42, unknown 976.1
2667 Female, age 75, unknown 970.1
2407 Male, age 75, both hemispheres 960.9
2224 Female, age 72, unknown 952.7
2273 Male, age 74, both hemispheres 946.6
1944 Female, age 72, unknown 928.7
2007 Male, age 72, unknown 910.1
1816 Male, age 51, unknown 878.7
Red nucleus
nTPM: 1259.8
2503 Female, age 72, unknown 1396.9
2769 Male, age 72, unknown 1349.6
2227 Male, age 72, unknown 1340.9
2823 Male, age 76, right hemisphere 1325.8
1904 Male, age 53, unknown 1321.6
1865 Male, age 51, unknown 1290.3
1821 Female, age 72, unknown 1281.0
2588 Male, age 74, left hemisphere 1258.2
1954 Female, age 42, unknown 1202.1
2785 Male, age 18, unknown 1165.8
2584 Male, age 75, left hemisphere 1097.5
2725 Female, age 75, unknown 1088.0
Substantia nigra
nTPM: 1063.3
2699 Male, age 18, unknown 1200.5
2590 Female, age 75, unknown 1123.8
2665 Male, age 74, both hemispheres 1112.9
1851 Male, age 51, unknown 1109.2
2583 Male, age 75, right hemisphere 1061.6
2409 Female, age 72, unknown 1029.2
1889 Female, age 72, unknown 1025.0
1916 Female, age 42, unknown 1017.6
1941 Male, age 53, unknown 979.2
2241 Male, age 72, unknown 974.0
Superior colliculus
nTPM: 1061.7
1913 Female, age 42, unknown 1275.8
1995 Male, age 72, unknown 1238.5
2587 Male, age 74, left hemisphere 1101.3
2668 Female, age 75, unknown 1095.3
1839 Male, age 51, unknown 1070.0
1895 Male, age 76, right hemisphere 1024.4
1796 Male, age 53, unknown 1003.0
2664 Male, age 75, both hemispheres 967.5
2087 Female, age 72, unknown 935.1
2261 Male, age 18, unknown 906.6
Ventral tegmental area
nTPM: 1112.0
2223 Female, age 72, unknown 1238.0
2410 Female, age 72, unknown 1155.8
2021 Male, age 53, unknown 1094.9
1942 Male, age 51, unknown 1075.5
1915 Female, age 42, unknown 1058.4
2218 Male, age 76, both hemispheres 1049.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1816.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 1816.7
Samples: 139

Max nTPM: 4227.9
Min nTPM: 442.7
Std nTPM: 740.3
Median nTPM: 1609.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 4227.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 4005.4
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 3473.8
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 3429.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 3402.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 3309.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 3299.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 3236.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 3212.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 3154.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 3121.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 3075.0
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 3059.3
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 3058.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 2923.8
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 2885.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 2865.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 2749.7
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 2737.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 2688.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 2639.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 2637.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 2586.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 2564.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 2511.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 2502.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 2462.1
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 2410.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 2399.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 2351.1
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 2329.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 2297.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 2286.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 2276.5
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 2224.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 2204.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 2136.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 2134.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 2124.2
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 2117.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 2105.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 2080.1
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 2078.7
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 2054.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 2053.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 2048.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 2000.7
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 1995.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 1984.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 1972.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 1950.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 1939.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 1893.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1862.6
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1861.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 1852.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 1848.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 1828.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 1827.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 1768.1
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 1756.0
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 1752.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 1749.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 1720.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 1687.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 1681.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 1627.6
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 1624.6
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 1616.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 1609.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 1606.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 1603.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 1591.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1579.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 1566.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 1561.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1554.6
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 1553.8
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 1546.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 1522.2
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 1518.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 1516.2
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 1508.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 1508.2
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 1498.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 1496.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 1476.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 1464.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 1449.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 1449.6
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 1447.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 1420.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 1405.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 1393.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 1372.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 1348.7
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 1344.0
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1342.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 1323.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 1313.7
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1312.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 1300.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 1288.0
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1285.4
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 1278.2
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 1274.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 1226.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 1225.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 1223.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 1220.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 1216.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 1190.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1189.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 1183.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 1179.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 1143.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 1143.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 1140.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 1132.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1128.2
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 1115.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 1114.7
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 1081.3
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 1075.5
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 1071.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 1068.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 1062.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 1027.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 995.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 971.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 935.7
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 889.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 866.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 783.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 769.1
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 625.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 590.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 526.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 442.7
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 1616.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 1616.4
FF:10158-103A5 76 years, female 1616.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 677.4
Pig sample Sample description nTPM
Midbrain
nTPM: 677.4
Samples: 4

Max nTPM: 1260.2
Min nTPM: 356.1
Sample A Female 1260.2
Sample B Female 734.7
Sample C Male 358.7
Sample D Male 356.1
Periaqueductal gray
nTPM: 597.1
Samples: 3

Max nTPM: 621.4
Min nTPM: 579.6
Sample B Female 621.4
Sample C Male 590.3
Sample D Male 579.6
Substantia nigra
nTPM: 625.0
Samples: 4

Max nTPM: 850.1
Min nTPM: 433.3
Sample A Female 634.2
Sample B Female 433.3
Sample C Male 582.5
Sample D Male 850.1
Superior colliculi
nTPM: 495.5
Samples: 4

Max nTPM: 595.1
Min nTPM: 314.8
Sample A Female 541.0
Sample B Female 314.8
Sample C Male 531.0
Sample D Male 595.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 697.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 697.2
Samples: 4

Max nTPM: 761.1
Min nTPM: 658.1
Sample A Male 761.1
Sample B Male 658.1
Sample C Female 660.5
Sample D Female 709.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 4.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 4.2
71836842 Antisense, RP_051017_02_C05, Mouse strain C57BL/6J (56 days, male) 7.2
68196931 Antisense, RP_041116_01_F10, Mouse strain C57BL/6J (56 days, male) 1.3

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.