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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:645.3 nTPM
HPA:645.3 nTPM
GTEx:863.5 nTPM
FANTOM5:4522.6 Scaled Tags Per Million
Pig:358.2 nTPM
Mouse:104.1 nTPM
Allen mouse:3.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 645.3
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 376.9
1870 Female, age 42, unknown 511.8
2019 Male, age 18, unknown 481.8
2411 Female, age 72, unknown 479.3
1830 Male, age 51, unknown 445.2
1833 Male, age 53, unknown 407.9
2828 Female, age 72, unknown 339.8
2666 Male, age 74, left hemisphere 305.1
1827 Male, age 72, unknown 278.8
2219 Male, age 76, both hemispheres 270.8
2586 Male, age 75, left hemisphere 249.0
Dorsal raphe nucleus
nTPM: 355.6
2750 Male, age 76, both hemispheres 418.0
1828 Male, age 53, unknown 410.7
2047 Male, age 72, unknown 341.7
2016 Female, age 72, unknown 323.1
2298 Female, age 72, unknown 284.4
Inferior colliculus
nTPM: 307.9
1848 Female, age 42, unknown 346.4
1890 Male, age 53, unknown 311.3
2097 Female, age 72, unknown 301.5
2849 Male, age 72, unknown 272.6
Median raphe nucleus
nTPM: 349.3
2220 Male, age 76, midline 349.3
Pedunculopontine tegmental nucleus
nTPM: 645.3
2338 Male, age 61, both hemispheres 1166.1
2334 Male, age 80, both hemispheres 427.0
1921 Female, age 85, both hemispheres 342.9
Periaquaductal grey, anterior
nTPM: 250.8
1947 Male, age 18, unknown 279.0
1795 Male, age 51, unknown 249.8
2502 Female, age 75, unknown 223.5
Periaquaductal grey, dorsal
nTPM: 253.6
2464 Female, age 72, unknown 297.3
1831 Male, age 72, unknown 269.2
2850 Male, age 76, both hemispheres 239.4
1840 Male, age 53, unknown 208.6
Periaquaductal grey, lateral
nTPM: 291.4
2272 Male, age 74, both hemispheres 360.0
2053 Male, age 18, unknown 280.9
2140 Male, age 76, both hemispheres 233.4
Pretectal area
nTPM: 299.5
2407 Male, age 75, both hemispheres 379.8
2273 Male, age 74, both hemispheres 359.0
1817 Female, age 42, unknown 345.3
2316 Male, age 76, right hemisphere 330.5
1815 Male, age 53, unknown 320.3
2007 Male, age 72, unknown 298.4
2825 Male, age 18, unknown 279.3
2224 Female, age 72, unknown 276.1
1944 Female, age 72, unknown 258.2
1816 Male, age 51, unknown 225.2
2667 Female, age 75, unknown 221.9
Red nucleus
nTPM: 557.0
1865 Male, age 51, unknown 760.2
1821 Female, age 72, unknown 751.4
1954 Female, age 42, unknown 676.8
1904 Male, age 53, unknown 664.9
2769 Male, age 72, unknown 602.3
2227 Male, age 72, unknown 594.2
2503 Female, age 72, unknown 527.5
2725 Female, age 75, unknown 512.9
2785 Male, age 18, unknown 490.2
2823 Male, age 76, right hemisphere 462.0
2584 Male, age 75, left hemisphere 338.3
2588 Male, age 74, left hemisphere 303.5
Substantia nigra
nTPM: 405.5
2590 Female, age 75, unknown 918.3
2409 Female, age 72, unknown 402.2
1889 Female, age 72, unknown 384.4
1851 Male, age 51, unknown 373.2
2583 Male, age 75, right hemisphere 354.5
1941 Male, age 53, unknown 348.5
2699 Male, age 18, unknown 345.0
2241 Male, age 72, unknown 343.0
1916 Female, age 42, unknown 333.9
2665 Male, age 74, both hemispheres 252.2
Superior colliculus
nTPM: 315.5
2587 Male, age 74, left hemisphere 466.2
1913 Female, age 42, unknown 408.5
1995 Male, age 72, unknown 339.1
1839 Male, age 51, unknown 320.7
1895 Male, age 76, right hemisphere 299.0
2668 Female, age 75, unknown 292.6
1796 Male, age 53, unknown 278.6
2087 Female, age 72, unknown 266.6
2261 Male, age 18, unknown 244.3
2664 Male, age 75, both hemispheres 238.9
Ventral tegmental area
nTPM: 388.8
2223 Female, age 72, unknown 513.8
2410 Female, age 72, unknown 459.4
2218 Male, age 76, both hemispheres 353.4
2021 Male, age 53, unknown 344.0
1915 Female, age 42, unknown 342.6
1942 Male, age 51, unknown 320.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 863.5
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 863.5
Samples: 139

Max nTPM: 4862.1
Min nTPM: 105.2
Std nTPM: 702.7
Median nTPM: 640.3
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 4862.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 3291.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 3142.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 2760.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 2682.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 2670.7
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 2536.7
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 2324.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 2158.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 2124.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 1876.8
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 1876.0
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 1838.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 1795.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 1787.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 1628.9
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 1620.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 1492.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 1459.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 1386.3
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1336.0
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 1314.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 1306.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 1228.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 1214.1
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 1197.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1193.4
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 1096.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1088.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 1047.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 1035.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 1016.6
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 1012.8
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 1011.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 1010.2
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 1008.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 969.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 968.4
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 956.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 956.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 949.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 946.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 936.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 936.2
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 925.4
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 877.9
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 877.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 877.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 852.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 835.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 834.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 833.4
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 783.8
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 783.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 778.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 773.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 763.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 760.7
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 752.8
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 735.8
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 711.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 707.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 698.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 693.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 680.8
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 672.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 667.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 655.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 654.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 640.3
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 634.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 620.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 616.5
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 611.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 607.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 592.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 581.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 567.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 562.3
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 553.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 545.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 544.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 543.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 539.9
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 531.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 531.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 525.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 506.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 499.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 490.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 485.8
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 484.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 483.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 480.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 466.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 466.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 453.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 446.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 445.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 443.5
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 437.4
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 437.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 433.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 429.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 425.9
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 423.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 421.8
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 418.4
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 417.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 405.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 399.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 399.5
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 398.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 398.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 390.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 389.6
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 388.5
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 387.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 379.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 376.4
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 370.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 364.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 358.7
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 342.6
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 339.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 332.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 314.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 303.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 301.5
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 277.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 267.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 250.8
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 243.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 233.1
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 203.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 202.8
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 172.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 151.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 105.2
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 4522.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 4522.6
FF:10158-103A5 76 years, female 4522.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 358.2
Pig sample Sample description nTPM
Midbrain
nTPM: 358.2
Samples: 4

Max nTPM: 782.7
Min nTPM: 125.2
Sample A Female 782.7
Sample B Female 315.3
Sample C Male 125.2
Sample D Male 209.7
Periaqueductal gray
nTPM: 200.2
Samples: 3

Max nTPM: 289.3
Min nTPM: 134.1
Sample B Female 289.3
Sample C Male 134.1
Sample D Male 177.3
Substantia nigra
nTPM: 310.2
Samples: 4

Max nTPM: 449.5
Min nTPM: 208.9
Sample A Female 346.7
Sample B Female 208.9
Sample C Male 235.7
Sample D Male 449.5
Superior colliculi
nTPM: 273.9
Samples: 4

Max nTPM: 405.5
Min nTPM: 159.2
Sample A Female 405.5
Sample B Female 159.2
Sample C Male 217.6
Sample D Male 313.3

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 104.1
Mouse sample Sample description nTPM
Midbrain
nTPM: 104.1
Samples: 4

Max nTPM: 124.6
Min nTPM: 92.4
Sample A Male 97.9
Sample B Male 124.6
Sample C Female 101.4
Sample D Female 92.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 3.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 3.9
513488 Antisense, RP_040810_01_H07, Mouse strain C57BL/6J (56 days, male) 4.4
75651180 Antisense, RP_060518_01_C06, Mouse strain C57BL/6J (56 days, male) 3.9
69015350 Antisense, RP_050310_02_G08, Mouse strain C57BL/6J (56 days, male) 3.4
70436740 Antisense, RP_050310_02_G08, Mouse strain C57BL/6J (56 days, male) 3.1

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