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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:1037.0 nTPM
HPA:1037.0 nTPM
GTEx:2764.5 nTPM
FANTOM5:1576.0 Scaled Tags Per Million
Pig:412.6 nTPM
Mouse:417.2 nTPM
Allen mouse:23.2 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 1037.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 786.6
2586 Male, age 75, left hemisphere 1192.2
2828 Female, age 72, unknown 981.9
2219 Male, age 76, both hemispheres 812.4
2666 Male, age 74, left hemisphere 773.3
1833 Male, age 53, unknown 767.1
1870 Female, age 42, unknown 715.9
1827 Male, age 72, unknown 714.1
1830 Male, age 51, unknown 684.4
2411 Female, age 72, unknown 680.1
2019 Male, age 18, unknown 545.0
Dorsal raphe nucleus
nTPM: 920.9
2047 Male, age 72, unknown 1009.9
2298 Female, age 72, unknown 978.6
2016 Female, age 72, unknown 929.9
2750 Male, age 76, both hemispheres 879.1
1828 Male, age 53, unknown 806.9
Inferior colliculus
nTPM: 766.2
1848 Female, age 42, unknown 784.7
1890 Male, age 53, unknown 772.2
2849 Male, age 72, unknown 754.6
2097 Female, age 72, unknown 753.3
Median raphe nucleus
nTPM: 916.9
2220 Male, age 76, midline 916.9
Pedunculopontine tegmental nucleus
nTPM: 869.7
2338 Male, age 61, both hemispheres 1053.6
1921 Female, age 85, both hemispheres 791.3
2334 Male, age 80, both hemispheres 764.1
Periaquaductal grey, anterior
nTPM: 857.8
1795 Male, age 51, unknown 913.2
1947 Male, age 18, unknown 851.2
2502 Female, age 75, unknown 808.9
Periaquaductal grey, dorsal
nTPM: 798.5
1840 Male, age 53, unknown 984.0
2850 Male, age 76, both hemispheres 814.4
2464 Female, age 72, unknown 716.0
1831 Male, age 72, unknown 679.8
Periaquaductal grey, lateral
nTPM: 765.5
2140 Male, age 76, both hemispheres 810.4
2272 Male, age 74, both hemispheres 758.9
2053 Male, age 18, unknown 727.2
Pretectal area
nTPM: 747.7
2224 Female, age 72, unknown 907.0
2825 Male, age 18, unknown 886.4
1817 Female, age 42, unknown 852.8
1944 Female, age 72, unknown 749.7
1815 Male, age 53, unknown 737.5
2007 Male, age 72, unknown 736.9
2667 Female, age 75, unknown 736.2
1816 Male, age 51, unknown 712.9
2316 Male, age 76, right hemisphere 704.1
2273 Male, age 74, both hemispheres 629.6
2407 Male, age 75, both hemispheres 571.7
Red nucleus
nTPM: 859.7
2227 Male, age 72, unknown 1032.8
2769 Male, age 72, unknown 1022.2
2503 Female, age 72, unknown 1005.5
2584 Male, age 75, left hemisphere 916.5
1954 Female, age 42, unknown 897.7
1904 Male, age 53, unknown 869.5
2725 Female, age 75, unknown 867.1
2823 Male, age 76, right hemisphere 852.9
1821 Female, age 72, unknown 807.7
1865 Male, age 51, unknown 786.7
2588 Male, age 74, left hemisphere 629.1
2785 Male, age 18, unknown 628.9
Substantia nigra
nTPM: 1037.0
2699 Male, age 18, unknown 1626.7
1916 Female, age 42, unknown 1373.7
1851 Male, age 51, unknown 1214.4
2665 Male, age 74, both hemispheres 1001.4
2590 Female, age 75, unknown 941.2
2583 Male, age 75, right hemisphere 924.5
2409 Female, age 72, unknown 894.1
1889 Female, age 72, unknown 881.0
2241 Male, age 72, unknown 791.5
1941 Male, age 53, unknown 721.4
Superior colliculus
nTPM: 710.6
1796 Male, age 53, unknown 869.9
2261 Male, age 18, unknown 781.0
2668 Female, age 75, unknown 772.2
2087 Female, age 72, unknown 771.6
2664 Male, age 75, both hemispheres 724.3
1995 Male, age 72, unknown 707.0
1839 Male, age 51, unknown 644.3
2587 Male, age 74, left hemisphere 627.7
1913 Female, age 42, unknown 621.7
1895 Male, age 76, right hemisphere 585.8
Ventral tegmental area
nTPM: 893.6
1915 Female, age 42, unknown 1126.9
1942 Male, age 51, unknown 955.3
2218 Male, age 76, both hemispheres 900.3
2021 Male, age 53, unknown 867.9
2410 Female, age 72, unknown 781.2
2223 Female, age 72, unknown 730.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 2764.5
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 2764.5
Samples: 139

Max nTPM: 8989.2
Min nTPM: 146.5
Std nTPM: 1606.7
Median nTPM: 2630.7
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 8989.2
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 7837.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 7598.0
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 6940.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 6421.7
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 5922.5
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 5711.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 5471.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 5406.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 5390.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 5361.1
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 5350.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 5324.8
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 5067.6
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 4959.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 4883.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 4787.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 4674.8
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 4608.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 4506.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 4436.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 4382.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 4252.3
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 4227.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 4170.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 4036.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 3838.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 3794.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 3728.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 3656.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 3550.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 3535.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 3512.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 3484.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 3463.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 3421.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 3387.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 3378.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 3368.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 3345.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 3287.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 3219.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 3214.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 3199.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 3141.6
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 3108.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 3085.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 3065.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 3063.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 3025.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 3002.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 2998.8
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 2975.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 2966.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 2935.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 2925.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 2920.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 2891.7
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 2829.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 2801.4
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 2769.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 2741.6
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 2723.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 2702.2
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 2697.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 2697.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 2669.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 2656.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 2651.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 2630.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 2562.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 2482.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 2377.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 2356.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 2351.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 2285.9
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 2279.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 2238.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 2203.6
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 2200.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 2176.2
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 2166.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 2157.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 2142.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 2139.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 2077.4
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 2057.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 2035.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 2002.1
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 1971.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 1954.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 1937.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 1899.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 1872.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 1857.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1840.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 1839.0
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 1826.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 1759.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 1740.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 1727.1
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 1712.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 1693.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 1663.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 1623.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 1620.4
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 1573.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 1568.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 1561.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 1518.4
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 1470.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 1459.0
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 1445.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 1438.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 1437.7
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 1386.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 1255.3
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 1212.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 1182.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1165.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1132.6
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 1120.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 1092.1
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 1044.5
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 992.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 894.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 845.6
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 830.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 784.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 730.7
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 716.8
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 664.8
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 555.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 541.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 497.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 493.8
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 483.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 413.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 146.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 1576.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 1576.0
FF:10158-103A5 76 years, female 1576.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 412.6
Pig sample Sample description nTPM
Midbrain
nTPM: 408.7
Samples: 4

Max nTPM: 516.4
Min nTPM: 276.1
Sample A Female 516.4
Sample B Female 508.1
Sample C Male 334.3
Sample D Male 276.1
Periaqueductal gray
nTPM: 412.6
Samples: 3

Max nTPM: 452.1
Min nTPM: 334.4
Sample B Female 452.1
Sample C Male 451.2
Sample D Male 334.4
Substantia nigra
nTPM: 409.4
Samples: 4

Max nTPM: 478.8
Min nTPM: 345.8
Sample A Female 478.8
Sample B Female 345.8
Sample C Male 425.2
Sample D Male 387.7
Superior colliculi
nTPM: 314.9
Samples: 4

Max nTPM: 386.1
Min nTPM: 207.1
Sample A Female 386.1
Sample B Female 207.1
Sample C Male 320.3
Sample D Male 346.2

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 417.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 417.3
Samples: 4

Max nTPM: 569.7
Min nTPM: 318.5
Sample A Male 569.7
Sample B Male 392.9
Sample C Female 318.5
Sample D Female 387.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 23.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 23.2
67936406 Antisense, RP_040604_02_C10, Mouse strain C57BL/6J (56 days, male) 28.0
77620395 Antisense, RP_070205_01_F04, Mouse strain C57BL/6J (56 days, male) 18.4
79490110 Antisense, RP_070205_01_F04, Mouse strain C57BL/6J (56 days, male) 15.5

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.