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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:481.9 nTPM
HPA:481.9 nTPM
GTEx:476.8 nTPM
FANTOM5:818.0 Scaled Tags Per Million
Pig:580.3 nTPM
Mouse:939.8 nTPM
Allen mouse:19.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 481.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 379.5
2666 Male, age 74, left hemisphere 431.0
2411 Female, age 72, unknown 414.7
1870 Female, age 42, unknown 403.0
1827 Male, age 72, unknown 401.8
2019 Male, age 18, unknown 388.6
1833 Male, age 53, unknown 381.6
2828 Female, age 72, unknown 377.9
1830 Male, age 51, unknown 361.3
2219 Male, age 76, both hemispheres 335.8
2586 Male, age 75, left hemisphere 299.5
Dorsal raphe nucleus
nTPM: 392.9
2047 Male, age 72, unknown 434.3
2298 Female, age 72, unknown 432.6
2750 Male, age 76, both hemispheres 420.8
1828 Male, age 53, unknown 363.9
2016 Female, age 72, unknown 313.0
Inferior colliculus
nTPM: 354.9
2097 Female, age 72, unknown 386.2
1890 Male, age 53, unknown 347.5
1848 Female, age 42, unknown 343.8
2849 Male, age 72, unknown 342.0
Median raphe nucleus
nTPM: 481.9
2220 Male, age 76, midline 481.9
Pedunculopontine tegmental nucleus
nTPM: 363.2
2334 Male, age 80, both hemispheres 386.4
1921 Female, age 85, both hemispheres 367.8
2338 Male, age 61, both hemispheres 335.4
Periaquaductal grey, anterior
nTPM: 382.2
2502 Female, age 75, unknown 441.1
1795 Male, age 51, unknown 362.9
1947 Male, age 18, unknown 342.4
Periaquaductal grey, dorsal
nTPM: 332.6
2464 Female, age 72, unknown 343.4
2850 Male, age 76, both hemispheres 332.1
1831 Male, age 72, unknown 329.5
1840 Male, age 53, unknown 325.4
Periaquaductal grey, lateral
nTPM: 353.0
2272 Male, age 74, both hemispheres 385.7
2053 Male, age 18, unknown 357.6
2140 Male, age 76, both hemispheres 315.7
Pretectal area
nTPM: 398.7
1944 Female, age 72, unknown 485.6
1816 Male, age 51, unknown 457.2
2007 Male, age 72, unknown 431.4
1817 Female, age 42, unknown 431.2
1815 Male, age 53, unknown 431.1
2667 Female, age 75, unknown 394.8
2273 Male, age 74, both hemispheres 370.2
2407 Male, age 75, both hemispheres 366.9
2224 Female, age 72, unknown 362.6
2825 Male, age 18, unknown 337.3
2316 Male, age 76, right hemisphere 317.1
Red nucleus
nTPM: 382.1
2785 Male, age 18, unknown 422.1
1904 Male, age 53, unknown 410.7
2503 Female, age 72, unknown 405.2
1821 Female, age 72, unknown 399.0
2725 Female, age 75, unknown 395.2
1865 Male, age 51, unknown 383.4
2588 Male, age 74, left hemisphere 381.7
1954 Female, age 42, unknown 378.0
2584 Male, age 75, left hemisphere 361.0
2227 Male, age 72, unknown 358.2
2769 Male, age 72, unknown 356.7
2823 Male, age 76, right hemisphere 334.4
Substantia nigra
nTPM: 362.0
1889 Female, age 72, unknown 429.7
1916 Female, age 42, unknown 403.3
1851 Male, age 51, unknown 384.4
1941 Male, age 53, unknown 376.4
2699 Male, age 18, unknown 357.6
2583 Male, age 75, right hemisphere 347.9
2590 Female, age 75, unknown 341.9
2409 Female, age 72, unknown 339.9
2665 Male, age 74, both hemispheres 320.0
2241 Male, age 72, unknown 318.5
Superior colliculus
nTPM: 379.3
2261 Male, age 18, unknown 425.0
2587 Male, age 74, left hemisphere 424.5
2087 Female, age 72, unknown 413.6
1913 Female, age 42, unknown 403.7
1796 Male, age 53, unknown 399.7
1995 Male, age 72, unknown 392.3
1895 Male, age 76, right hemisphere 367.9
1839 Male, age 51, unknown 352.1
2668 Female, age 75, unknown 330.2
2664 Male, age 75, both hemispheres 283.8
Ventral tegmental area
nTPM: 371.4
2410 Female, age 72, unknown 404.2
2218 Male, age 76, both hemispheres 393.0
2223 Female, age 72, unknown 392.4
1915 Female, age 42, unknown 377.1
1942 Male, age 51, unknown 348.1
2021 Male, age 53, unknown 313.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 476.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 476.8
Samples: 139

Max nTPM: 1109.4
Min nTPM: 278.7
Std nTPM: 125.6
Median nTPM: 447.2
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 1109.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 867.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 764.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 757.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 735.0
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 724.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 710.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 707.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 690.9
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 678.0
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 650.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 649.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 645.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 642.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 641.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 637.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 607.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 605.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 604.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 604.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 603.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 594.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 587.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 580.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 579.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 579.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 579.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 576.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 572.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 568.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 566.8
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 563.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 562.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 555.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 555.7
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 555.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 547.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 545.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 540.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 537.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 532.3
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 530.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 512.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 508.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 503.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 503.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 500.9
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 496.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 494.2
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 493.0
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 492.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 490.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 489.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 485.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 483.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 482.1
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 479.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 479.7
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 471.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 471.0
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 469.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 464.6
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 457.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 452.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 450.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 450.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 448.5
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 448.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 447.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 447.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 445.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 443.8
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 441.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 439.9
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 438.5
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 437.7
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 437.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 436.3
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 435.2
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 431.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 429.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 429.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 428.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 425.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 425.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 424.0
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 423.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 420.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 420.0
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 417.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 415.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 413.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 412.6
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 411.9
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 409.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 408.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 407.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 396.8
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 396.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 395.8
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 393.6
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 392.1
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 390.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 390.5
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 389.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 388.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 387.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 386.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 385.1
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 381.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 380.7
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 373.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 372.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 372.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 368.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 368.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 365.1
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 363.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 360.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 359.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 355.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 352.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 351.9
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 346.6
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 346.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 340.7
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 332.1
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 330.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 329.2
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 329.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 327.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 326.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 325.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 315.0
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 307.0
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 302.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 293.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 284.3
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 278.7
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 818.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 818.0
FF:10158-103A5 76 years, female 818.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 580.3
Pig sample Sample description nTPM
Midbrain
nTPM: 580.3
Samples: 4

Max nTPM: 944.8
Min nTPM: 345.2
Sample A Female 560.2
Sample B Female 345.2
Sample C Male 944.8
Sample D Male 471.1
Periaqueductal gray
nTPM: 302.5
Samples: 3

Max nTPM: 331.2
Min nTPM: 258.2
Sample B Female 318.1
Sample C Male 331.2
Sample D Male 258.2
Substantia nigra
nTPM: 440.3
Samples: 4

Max nTPM: 518.5
Min nTPM: 363.1
Sample A Female 518.5
Sample B Female 363.1
Sample C Male 460.1
Sample D Male 419.3
Superior colliculi
nTPM: 536.6
Samples: 4

Max nTPM: 639.3
Min nTPM: 461.9
Sample A Female 543.7
Sample B Female 501.3
Sample C Male 639.3
Sample D Male 461.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 939.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 939.9
Samples: 4

Max nTPM: 1000.5
Min nTPM: 874.3
Sample A Male 874.3
Sample B Male 930.5
Sample C Female 1000.5
Sample D Female 954.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 19.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 19.0
79591705 Antisense, RP_071218_02_B09, Mouse strain C57BL/6J (56 days, male) 30.6
106 Antisense, RP_Baylor_253875, Mouse strain C57BL/6J (56 days, male) 26.2
107 Antisense, RP_Baylor_253875, Mouse strain C57BL/6J (56 days, male) 21.6
70611467 Antisense, RP_050630_03_C12, Mouse strain C57BL/6J (56 days, male) 0.0

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