Detection of cancer is a challenging task, especially since many common diffuse symptoms overlap with non-malignant conditions. In an article in Nature Communications it was shown that plasma protein profiling can be used to identify cancer among patients with non-specific symptoms...Read more

The Human Pan Disease Atlas article is now available in the latest issue of Science released December 18. The article describes how a next-generation targeted proteomics assay was used to analyze the blood profiles of thousands of patients representing most major disease classes, and to assess the stability and variability of protein profiles in healthy adults as well as for the child to adult development...Read more

In an article in PNAS HPA related researchers have used a combinatorial protein library to select binders against the overexpressed cancer receptor EGFR. The design of the scaffold protein allows for selection of both calcium -and pH dependency, an approach that can generate fine-tuned binders and possibly enable new treatment regimes...Read more

In an article published in PNAS, researchers have used the recombinant expression of more than 2000 Human Secretome Project proteins to investigate the factors influencing recombinant protein expression in CHO cells...Read more

In the journal Cell, researchers publish a deep analysis of the HPA primary cilia section, first introduced in HPA v24. The HPA subcellular resource portrays primary cilia as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, and inspires many new views on this tiny antenna...Read more