The research article "Tissue-based map of the human proteome" has reached a major milestone with more than 10,000 citations according to Google Scholar...Read more

In a study led by researchers in the HPA and at Brunel University London, a novel method for automated annotation of immunohistochemistry images was developed for annotating cell type-specific protein expression of 8 different cell types in human testis. The work comprised 7848 images (corresponding to 2794 proteins) and the image classifier also provided a novel uncertainty metrics (called DeepHistoClass), for identification of manual annotation errors. The workflow can be implemented for other tissues or utilized in large-scale protein mapping efforts for sourcing high-quality data...Read more

Researchers within the HPA have described the presence of the enzyme ACE2 in the entire human body, which is suggested to be the key protein used by the SARS-CoV-2 virus for host cell entry and development of the disease COVID-19. In contrast to previous studies, the study shows that none or only very low levels of ACE2 protein is present in the normal respiratory system. The results are presented in Molecular Systems Biology...Read more

The HPA team plans to release a series of "Movie of the month" during 2020. These movies are based on the Human Protein Atlas program, including antibody-based 3D profiling of tissues using light sheet microscopy performed by Dr Csaba Adori at Karolinska Institutet, Stockholm...Read more

Today, an article was published in bioRxiv (Hikmet et al) describing the presence in the human body of the enzyme Angiotensin I converting enzyme 2 (ACE2), previously proposed to be the main target for coronavirus attachment to the surface of human cells...Read more