G-protein coupled receptors (GPCRs) are a large family of cell surface receptors important for activating cellular responses. They are activated by many types of signals like light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters and are involved in a wide range of diseases which have made them important drug targets. Receptor activity-modifying proteins (RAMPs) form complexes with the GPCRs and may regulate their cellular trafficking and pharmacology...Read more

In a recent publication in Science Advances, the selectivity of antibodies against subfamilies of G protein-coupled receptors (GPCRs) was investigated using a multiplexed immunoassay and a customized library of solubilized GPCRs...Read more