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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:2602.9 nTPM
HPA:2602.9 nTPM
GTEx:1192.3 nTPM
FANTOM5:478.5 Scaled Tags Per Million
Mouse:0.1 nTPM
Allen mouse:17.6 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 2602.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 2487.3
2666 Male, age 74, left hemisphere 2564.9
1827 Male, age 72, unknown 2562.9
2828 Female, age 72, unknown 2520.9
1870 Female, age 42, unknown 2498.9
2019 Male, age 18, unknown 2484.2
2411 Female, age 72, unknown 2478.1
1830 Male, age 51, unknown 2456.1
2219 Male, age 76, both hemispheres 2448.4
1833 Male, age 53, unknown 2447.8
2586 Male, age 75, left hemisphere 2410.7
Dorsal raphe nucleus
nTPM: 2512.2
2298 Female, age 72, unknown 2573.9
2750 Male, age 76, both hemispheres 2551.3
2047 Male, age 72, unknown 2528.4
1828 Male, age 53, unknown 2479.3
2016 Female, age 72, unknown 2427.8
Inferior colliculus
nTPM: 2448.5
2097 Female, age 72, unknown 2464.7
2849 Male, age 72, unknown 2458.9
1848 Female, age 42, unknown 2440.7
1890 Male, age 53, unknown 2429.9
Median raphe nucleus
nTPM: 2592.3
2220 Male, age 76, midline 2592.3
Pedunculopontine tegmental nucleus
nTPM: 2602.9
2338 Male, age 61, both hemispheres 2752.2
2334 Male, age 80, both hemispheres 2582.1
1921 Female, age 85, both hemispheres 2474.3
Periaquaductal grey, anterior
nTPM: 2590.4
1795 Male, age 51, unknown 2681.3
1947 Male, age 18, unknown 2559.0
2502 Female, age 75, unknown 2530.8
Periaquaductal grey, dorsal
nTPM: 2495.4
2850 Male, age 76, both hemispheres 2559.6
1831 Male, age 72, unknown 2530.0
1840 Male, age 53, unknown 2454.0
2464 Female, age 72, unknown 2438.2
Periaquaductal grey, lateral
nTPM: 2503.4
2272 Male, age 74, both hemispheres 2538.8
2140 Male, age 76, both hemispheres 2496.4
2053 Male, age 18, unknown 2474.9
Pretectal area
nTPM: 2599.2
1816 Male, age 51, unknown 2845.1
1944 Female, age 72, unknown 2798.0
2007 Male, age 72, unknown 2681.7
1817 Female, age 42, unknown 2679.1
1815 Male, age 53, unknown 2662.5
2224 Female, age 72, unknown 2522.1
2667 Female, age 75, unknown 2514.5
2825 Male, age 18, unknown 2498.0
2273 Male, age 74, both hemispheres 2481.0
2316 Male, age 76, right hemisphere 2455.2
2407 Male, age 75, both hemispheres 2453.7
Red nucleus
nTPM: 2446.9
2725 Female, age 75, unknown 2548.8
2785 Male, age 18, unknown 2528.9
2588 Male, age 74, left hemisphere 2489.7
2823 Male, age 76, right hemisphere 2465.9
2584 Male, age 75, left hemisphere 2464.0
2503 Female, age 72, unknown 2457.3
1821 Female, age 72, unknown 2418.4
1904 Male, age 53, unknown 2404.4
1865 Male, age 51, unknown 2399.3
1954 Female, age 42, unknown 2397.3
2227 Male, age 72, unknown 2395.5
2769 Male, age 72, unknown 2393.9
Substantia nigra
nTPM: 2531.0
2665 Male, age 74, both hemispheres 2672.7
1889 Female, age 72, unknown 2634.3
1941 Male, age 53, unknown 2589.7
1916 Female, age 42, unknown 2539.3
1851 Male, age 51, unknown 2532.2
2590 Female, age 75, unknown 2513.2
2583 Male, age 75, right hemisphere 2467.8
2409 Female, age 72, unknown 2464.9
2699 Male, age 18, unknown 2457.5
2241 Male, age 72, unknown 2438.4
Superior colliculus
nTPM: 2536.8
2087 Female, age 72, unknown 2634.7
2261 Male, age 18, unknown 2625.3
1913 Female, age 42, unknown 2605.3
1796 Male, age 53, unknown 2602.2
2587 Male, age 74, left hemisphere 2548.5
1995 Male, age 72, unknown 2545.7
2668 Female, age 75, unknown 2503.4
1895 Male, age 76, right hemisphere 2461.9
1839 Male, age 51, unknown 2442.4
2664 Male, age 75, both hemispheres 2399.0
Ventral tegmental area
nTPM: 2536.7
2223 Female, age 72, unknown 2585.3
2218 Male, age 76, both hemispheres 2574.6
2021 Male, age 53, unknown 2548.5
1915 Female, age 42, unknown 2526.8
1942 Male, age 51, unknown 2499.1
2410 Female, age 72, unknown 2486.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1192.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 1192.3
Samples: 139

Max nTPM: 3237.9
Min nTPM: 572.8
Std nTPM: 458.2
Median nTPM: 1096.3
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 3237.9
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 2813.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 2561.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 2507.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 2435.2
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 2404.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 2367.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 2061.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 1941.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 1892.5
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 1836.4
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 1833.0
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1787.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 1761.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 1680.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 1668.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 1653.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 1650.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 1634.1
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 1601.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 1576.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 1564.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 1537.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 1508.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 1503.1
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 1500.8
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 1464.6
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1459.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1439.9
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 1428.0
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 1413.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 1410.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 1408.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 1404.2
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 1398.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 1366.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 1333.9
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 1322.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 1321.6
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1298.6
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 1298.5
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 1297.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 1270.5
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 1268.6
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1260.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 1257.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 1255.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 1255.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1250.1
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 1233.4
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 1228.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 1223.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 1216.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 1194.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 1186.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 1178.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 1164.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1157.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1142.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 1138.9
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 1136.3
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 1132.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 1132.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 1129.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 1127.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1118.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 1115.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 1101.3
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 1098.7
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 1096.3
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 1096.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 1080.2
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 1077.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 1061.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 1056.6
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 1034.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 1030.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 1026.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 1023.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 1012.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 1007.6
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 1002.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 989.9
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 987.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 981.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 977.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 976.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 974.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 973.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 972.2
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 969.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 955.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 953.1
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 952.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 939.9
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 933.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 930.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 925.5
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 924.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 924.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 924.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 920.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 915.3
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 913.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 911.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 900.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 887.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 877.7
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 868.8
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 866.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 850.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 848.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 842.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 837.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 837.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 833.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 819.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 817.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 809.5
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 800.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 779.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 775.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 775.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 770.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 750.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 720.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 713.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 711.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 704.1
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 695.2
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 661.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 661.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 660.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 633.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 622.8
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 616.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 610.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 602.2
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 572.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 478.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 478.5
FF:10158-103A5 76 years, female 478.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 0.1
Mouse sample Sample description nTPM
Midbrain
nTPM: 0.1
Samples: 4

Max nTPM: 0.3
Min nTPM: 0.0
Sample A Male 0.2
Sample B Male 0.0
Sample C Female 0.3
Sample D Female 0.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 17.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 17.6
73521810 Antisense, RP_051101_03_A09, Mouse strain C57BL/6J (56 days, male) 18.3
69816996 Antisense, RP_050510_02_D07, Mouse strain C57BL/6J (56 days, male) 16.8

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