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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:8450.9 nTPM
HPA:8450.9 nTPM
GTEx:5838.9 nTPM
FANTOM5:3628.0 Scaled Tags Per Million
Pig:2817.7 nTPM
Mouse:794.6 nTPM
Allen mouse:14.3 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 8450.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 6262.1
2828 Female, age 72, unknown 7369.3
2586 Male, age 75, left hemisphere 6955.3
1827 Male, age 72, unknown 6452.7
2019 Male, age 18, unknown 6375.6
1870 Female, age 42, unknown 6358.7
1833 Male, age 53, unknown 6074.9
2666 Male, age 74, left hemisphere 5883.0
1830 Male, age 51, unknown 5855.8
2411 Female, age 72, unknown 5671.3
2219 Male, age 76, both hemispheres 5624.2
Dorsal raphe nucleus
nTPM: 7167.5
2298 Female, age 72, unknown 7939.8
2016 Female, age 72, unknown 7603.9
2047 Male, age 72, unknown 7044.5
1828 Male, age 53, unknown 7022.9
2750 Male, age 76, both hemispheres 6226.3
Inferior colliculus
nTPM: 6832.8
2849 Male, age 72, unknown 7011.9
2097 Female, age 72, unknown 6967.5
1848 Female, age 42, unknown 6855.4
1890 Male, age 53, unknown 6496.1
Median raphe nucleus
nTPM: 6768.6
2220 Male, age 76, midline 6768.6
Pedunculopontine tegmental nucleus
nTPM: 6516.5
2338 Male, age 61, both hemispheres 6766.4
1921 Female, age 85, both hemispheres 6461.4
2334 Male, age 80, both hemispheres 6321.5
Periaquaductal grey, anterior
nTPM: 6933.4
1795 Male, age 51, unknown 7425.7
2502 Female, age 75, unknown 6910.5
1947 Male, age 18, unknown 6464.1
Periaquaductal grey, dorsal
nTPM: 7505.2
2850 Male, age 76, both hemispheres 9103.0
1840 Male, age 53, unknown 7811.5
1831 Male, age 72, unknown 6823.9
2464 Female, age 72, unknown 6282.5
Periaquaductal grey, lateral
nTPM: 8450.9
2272 Male, age 74, both hemispheres 8916.1
2140 Male, age 76, both hemispheres 8642.1
2053 Male, age 18, unknown 7794.5
Pretectal area
nTPM: 7395.5
2273 Male, age 74, both hemispheres 10770.7
2407 Male, age 75, both hemispheres 8380.1
1944 Female, age 72, unknown 7570.6
2667 Female, age 75, unknown 7450.9
1817 Female, age 42, unknown 6960.5
2224 Female, age 72, unknown 6938.1
2825 Male, age 18, unknown 6891.1
1816 Male, age 51, unknown 6866.0
1815 Male, age 53, unknown 6667.3
2316 Male, age 76, right hemisphere 6435.8
2007 Male, age 72, unknown 6419.4
Red nucleus
nTPM: 6180.7
2725 Female, age 75, unknown 6606.0
2227 Male, age 72, unknown 6352.4
2769 Male, age 72, unknown 6341.1
2503 Female, age 72, unknown 6302.9
2785 Male, age 18, unknown 6287.9
1821 Female, age 72, unknown 6253.4
1865 Male, age 51, unknown 6237.7
1904 Male, age 53, unknown 6155.4
1954 Female, age 42, unknown 6141.7
2823 Male, age 76, right hemisphere 6056.6
2584 Male, age 75, left hemisphere 5905.7
2588 Male, age 74, left hemisphere 5527.6
Substantia nigra
nTPM: 6375.4
2699 Male, age 18, unknown 7227.4
1916 Female, age 42, unknown 6763.9
1851 Male, age 51, unknown 6647.2
1889 Female, age 72, unknown 6583.1
1941 Male, age 53, unknown 6488.2
2409 Female, age 72, unknown 6333.1
2241 Male, age 72, unknown 6107.3
2590 Female, age 75, unknown 6074.6
2583 Male, age 75, right hemisphere 5899.1
2665 Male, age 74, both hemispheres 5630.4
Superior colliculus
nTPM: 6884.8
2664 Male, age 75, both hemispheres 7803.5
1995 Male, age 72, unknown 7516.2
2087 Female, age 72, unknown 7222.6
2587 Male, age 74, left hemisphere 7055.6
1913 Female, age 42, unknown 6963.4
1796 Male, age 53, unknown 6955.0
2261 Male, age 18, unknown 6671.7
2668 Female, age 75, unknown 6448.8
1839 Male, age 51, unknown 6376.7
1895 Male, age 76, right hemisphere 5834.3
Ventral tegmental area
nTPM: 6625.7
2021 Male, age 53, unknown 7016.7
1942 Male, age 51, unknown 6970.9
1915 Female, age 42, unknown 6825.6
2223 Female, age 72, unknown 6524.8
2218 Male, age 76, both hemispheres 6394.5
2410 Female, age 72, unknown 6021.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 5838.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 5838.9
Samples: 139

Max nTPM: 19960.2
Min nTPM: 1211.4
Std nTPM: 3649.0
Median nTPM: 4725.7
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 19960.2
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 17175.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 16411.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 16273.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 16062.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 14269.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 14234.1
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 13888.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 12824.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 12732.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 12058.2
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 11717.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 11643.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 11553.4
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 11217.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 11113.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 10770.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 10319.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 10297.9
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 10258.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 10211.6
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 9917.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 8946.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 8606.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 8348.7
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 8324.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 7993.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 7898.5
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 7861.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 7685.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 7525.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 7342.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 7057.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 7044.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 7004.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 6812.8
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 6711.8
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 6632.5
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 6514.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 6420.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 6393.0
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 6296.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 6273.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 6241.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 6205.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 6132.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 6039.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 6014.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 5986.2
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 5964.9
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 5960.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 5810.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 5782.0
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 5687.1
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 5552.2
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 5388.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 5375.2
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 5228.8
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 5103.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 5082.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 5065.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 5061.4
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 5043.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 4958.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 4933.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 4871.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 4833.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 4830.0
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 4766.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 4725.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 4691.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 4690.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 4647.1
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 4639.5
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 4592.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 4500.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 4448.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 4438.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 4408.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 4382.2
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 4364.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 4336.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 4234.2
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 4191.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 4177.8
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 4098.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 4043.2
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 4040.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 3876.9
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 3845.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 3837.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 3808.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 3784.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 3781.9
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 3777.0
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 3768.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 3726.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 3702.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 3678.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 3632.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 3586.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 3542.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 3474.9
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 3441.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 3382.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 3371.6
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 3324.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 3305.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 3276.6
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 3021.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 2921.1
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 2920.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 2874.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 2863.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 2848.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 2813.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 2796.4
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 2772.1
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 2654.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 2645.2
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 2638.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 2608.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 2601.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 2598.6
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 2474.6
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 2406.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 2291.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 2239.3
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 2217.4
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 2198.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 2175.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 2037.8
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 2037.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 1935.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1918.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 1910.4
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 1458.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 1413.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 1211.4
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 3628.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 3628.0
FF:10158-103A5 76 years, female 3628.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 2817.7
Pig sample Sample description nTPM
Midbrain
nTPM: 2545.2
Samples: 4

Max nTPM: 3505.7
Min nTPM: 1639.8
Sample A Female 3505.7
Sample B Female 2429.5
Sample C Male 2605.7
Sample D Male 1639.8
Periaqueductal gray
nTPM: 2661.5
Samples: 3

Max nTPM: 2903.9
Min nTPM: 2342.7
Sample B Female 2738.0
Sample C Male 2903.9
Sample D Male 2342.7
Substantia nigra
nTPM: 2533.9
Samples: 4

Max nTPM: 2761.2
Min nTPM: 2372.0
Sample A Female 2761.2
Sample B Female 2457.1
Sample C Male 2372.0
Sample D Male 2545.2
Superior colliculi
nTPM: 2817.8
Samples: 4

Max nTPM: 3675.1
Min nTPM: 2171.1
Sample A Female 3117.9
Sample B Female 3675.1
Sample C Male 2306.9
Sample D Male 2171.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 794.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 794.6
Samples: 4

Max nTPM: 869.7
Min nTPM: 751.8
Sample A Male 869.7
Sample B Male 751.8
Sample C Female 793.0
Sample D Female 763.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 14.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 14.3
77800883 Antisense, RP_070212_01_A02, Mouse strain C57BL/6J (56 days, male) 22.0
79490114 Antisense, RP_070212_01_A02, Mouse strain C57BL/6J (56 days, male) 16.2
276 Antisense, RP_Baylor_102693, Mouse strain C57BL/6J (56 days, male) 6.5
275 Antisense, RP_Baylor_102693, Mouse strain C57BL/6J (56 days, male) 2.3

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