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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:730.9 nTPM
HPA:730.9 nTPM
GTEx:623.1 nTPM
FANTOM5:1024.6 Scaled Tags Per Million
Pig:1036.1 nTPM
Mouse:2601.5 nTPM
Allen mouse:21.6 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 730.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 536.7
1830 Male, age 51, unknown 608.9
2586 Male, age 75, left hemisphere 599.1
1833 Male, age 53, unknown 564.4
2411 Female, age 72, unknown 561.3
2019 Male, age 18, unknown 534.1
2219 Male, age 76, both hemispheres 532.1
2828 Female, age 72, unknown 504.7
2666 Male, age 74, left hemisphere 497.0
1870 Female, age 42, unknown 491.4
1827 Male, age 72, unknown 473.8
Dorsal raphe nucleus
nTPM: 730.9
2047 Male, age 72, unknown 899.9
2016 Female, age 72, unknown 740.4
1828 Male, age 53, unknown 735.5
2298 Female, age 72, unknown 680.4
2750 Male, age 76, both hemispheres 598.1
Inferior colliculus
nTPM: 620.1
1890 Male, age 53, unknown 709.6
2097 Female, age 72, unknown 693.6
2849 Male, age 72, unknown 562.7
1848 Female, age 42, unknown 514.3
Median raphe nucleus
nTPM: 698.7
2220 Male, age 76, midline 698.7
Pedunculopontine tegmental nucleus
nTPM: 646.9
2338 Male, age 61, both hemispheres 677.3
2334 Male, age 80, both hemispheres 661.7
1921 Female, age 85, both hemispheres 601.7
Periaquaductal grey, anterior
nTPM: 546.0
1947 Male, age 18, unknown 649.2
2502 Female, age 75, unknown 526.6
1795 Male, age 51, unknown 462.3
Periaquaductal grey, dorsal
nTPM: 589.0
2850 Male, age 76, both hemispheres 679.2
1840 Male, age 53, unknown 598.9
2464 Female, age 72, unknown 582.7
1831 Male, age 72, unknown 495.2
Periaquaductal grey, lateral
nTPM: 526.1
2140 Male, age 76, both hemispheres 591.1
2272 Male, age 74, both hemispheres 510.7
2053 Male, age 18, unknown 476.4
Pretectal area
nTPM: 482.6
2273 Male, age 74, both hemispheres 583.2
2407 Male, age 75, both hemispheres 545.9
2825 Male, age 18, unknown 526.6
2224 Female, age 72, unknown 523.4
2316 Male, age 76, right hemisphere 481.9
2667 Female, age 75, unknown 465.2
1817 Female, age 42, unknown 448.0
1944 Female, age 72, unknown 445.2
2007 Male, age 72, unknown 435.4
1816 Male, age 51, unknown 432.1
1815 Male, age 53, unknown 421.3
Red nucleus
nTPM: 618.1
1821 Female, age 72, unknown 734.3
1865 Male, age 51, unknown 703.5
1954 Female, age 42, unknown 699.4
2725 Female, age 75, unknown 657.0
2769 Male, age 72, unknown 651.6
2227 Male, age 72, unknown 650.6
2503 Female, age 72, unknown 601.7
1904 Male, age 53, unknown 582.2
2823 Male, age 76, right hemisphere 576.3
2588 Male, age 74, left hemisphere 546.1
2584 Male, age 75, left hemisphere 538.0
2785 Male, age 18, unknown 476.5
Substantia nigra
nTPM: 699.2
2699 Male, age 18, unknown 957.7
1916 Female, age 42, unknown 782.8
2241 Male, age 72, unknown 739.2
1851 Male, age 51, unknown 720.1
1941 Male, age 53, unknown 696.4
2590 Female, age 75, unknown 695.8
2665 Male, age 74, both hemispheres 651.1
2409 Female, age 72, unknown 614.3
2583 Male, age 75, right hemisphere 595.2
1889 Female, age 72, unknown 539.0
Superior colliculus
nTPM: 500.5
1995 Male, age 72, unknown 609.4
1913 Female, age 42, unknown 548.9
2587 Male, age 74, left hemisphere 527.9
1796 Male, age 53, unknown 508.6
2664 Male, age 75, both hemispheres 501.6
1839 Male, age 51, unknown 479.4
2668 Female, age 75, unknown 473.1
1895 Male, age 76, right hemisphere 461.1
2087 Female, age 72, unknown 451.2
2261 Male, age 18, unknown 444.4
Ventral tegmental area
nTPM: 687.2
1942 Male, age 51, unknown 799.0
2223 Female, age 72, unknown 757.0
1915 Female, age 42, unknown 700.2
2021 Male, age 53, unknown 663.2
2218 Male, age 76, both hemispheres 625.2
2410 Female, age 72, unknown 578.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 623.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 623.1
Samples: 139

Max nTPM: 2488.3
Min nTPM: 159.3
Std nTPM: 413.7
Median nTPM: 500.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 2488.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 2225.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 2180.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 1791.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 1767.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 1552.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 1548.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1455.4
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 1367.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1293.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 1280.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 1225.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 1197.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 1135.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 1106.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 1102.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 1057.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 1014.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 997.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 979.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 966.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 898.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 892.6
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 891.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 870.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 859.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 851.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 850.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 836.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 834.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 801.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 801.0
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 762.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 741.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 736.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 734.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 730.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 718.7
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 705.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 702.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 683.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 671.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 670.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 670.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 659.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 653.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 650.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 646.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 644.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 636.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 619.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 615.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 606.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 591.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 589.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 586.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 571.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 561.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 540.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 538.5
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 537.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 537.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 531.4
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 526.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 522.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 516.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 516.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 515.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 504.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 500.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 497.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 493.1
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 487.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 479.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 476.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 475.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 465.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 463.1
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 461.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 455.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 449.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 441.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 435.4
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 434.0
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 432.9
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 432.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 429.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 425.7
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 422.4
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 419.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 417.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 414.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 408.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 402.8
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 402.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 399.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 397.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 394.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 391.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 391.2
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 389.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 383.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 379.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 372.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 365.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 364.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 357.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 354.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 347.1
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 346.2
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 341.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 325.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 323.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 317.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 308.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 304.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 302.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 285.8
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 285.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 284.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 276.9
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 271.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 268.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 268.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 266.3
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 262.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 245.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 238.8
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 218.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 218.0
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 210.7
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 208.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 205.4
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 191.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 185.8
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 183.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 167.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 165.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 159.3
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 1024.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 1024.6
FF:10158-103A5 76 years, female 1024.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1036.1
Pig sample Sample description nTPM
Midbrain
nTPM: 946.9
Samples: 4

Max nTPM: 1119.1
Min nTPM: 863.3
Sample A Female 915.6
Sample B Female 1119.1
Sample C Male 889.6
Sample D Male 863.3
Periaqueductal gray
nTPM: 1036.1
Samples: 3

Max nTPM: 1231.7
Min nTPM: 854.4
Sample B Female 1231.7
Sample C Male 1022.2
Sample D Male 854.4
Substantia nigra
nTPM: 934.8
Samples: 4

Max nTPM: 995.6
Min nTPM: 872.5
Sample A Female 976.3
Sample B Female 995.6
Sample C Male 894.8
Sample D Male 872.5
Superior colliculi
nTPM: 825.9
Samples: 4

Max nTPM: 954.7
Min nTPM: 462.1
Sample A Female 952.4
Sample B Female 462.1
Sample C Male 934.3
Sample D Male 954.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 2601.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 2601.5
Samples: 4

Max nTPM: 2676.5
Min nTPM: 2559.9
Sample A Male 2559.9
Sample B Male 2571.1
Sample C Female 2676.5
Sample D Female 2598.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 21.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 21.6
70429447 Antisense, RP_050614_01_F10, Mouse strain C57BL/6J (56 days, male) 21.6
74750016 Antisense, RP_060220_05_E06, Mouse strain C57BL/6J (56 days, male) 21.5

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