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RPS21
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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:1347.8 nTPM
HPA:1347.8 nTPM
GTEx:1620.4 nTPM
FANTOM5:341.0 Scaled Tags Per Million
Pig:199.3 nTPM
Mouse:873.8 nTPM
Allen mouse:4.7 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 1347.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 1316.0
2411 Female, age 72, unknown 1344.9
1870 Female, age 42, unknown 1329.3
2219 Male, age 76, both hemispheres 1324.9
2019 Male, age 18, unknown 1321.4
2586 Male, age 75, left hemisphere 1317.4
2828 Female, age 72, unknown 1315.8
1827 Male, age 72, unknown 1311.4
1833 Male, age 53, unknown 1299.5
2666 Male, age 74, left hemisphere 1298.1
1830 Male, age 51, unknown 1297.6
Dorsal raphe nucleus
nTPM: 1320.9
2298 Female, age 72, unknown 1364.5
2750 Male, age 76, both hemispheres 1325.4
2016 Female, age 72, unknown 1317.7
1828 Male, age 53, unknown 1302.3
2047 Male, age 72, unknown 1294.9
Inferior colliculus
nTPM: 1314.0
2097 Female, age 72, unknown 1342.0
1890 Male, age 53, unknown 1330.5
1848 Female, age 42, unknown 1301.4
2849 Male, age 72, unknown 1282.1
Median raphe nucleus
nTPM: 1306.9
2220 Male, age 76, midline 1306.9
Pedunculopontine tegmental nucleus
nTPM: 1334.8
2334 Male, age 80, both hemispheres 1339.6
2338 Male, age 61, both hemispheres 1338.7
1921 Female, age 85, both hemispheres 1326.0
Periaquaductal grey, anterior
nTPM: 1344.8
2502 Female, age 75, unknown 1379.3
1795 Male, age 51, unknown 1333.0
1947 Male, age 18, unknown 1322.1
Periaquaductal grey, dorsal
nTPM: 1308.4
1840 Male, age 53, unknown 1322.7
2464 Female, age 72, unknown 1321.7
1831 Male, age 72, unknown 1307.2
2850 Male, age 76, both hemispheres 1282.2
Periaquaductal grey, lateral
nTPM: 1297.6
2053 Male, age 18, unknown 1311.1
2140 Male, age 76, both hemispheres 1296.9
2272 Male, age 74, both hemispheres 1284.9
Pretectal area
nTPM: 1317.3
1816 Male, age 51, unknown 1338.0
2007 Male, age 72, unknown 1336.9
2224 Female, age 72, unknown 1334.8
2316 Male, age 76, right hemisphere 1328.0
1817 Female, age 42, unknown 1325.4
1815 Male, age 53, unknown 1317.5
2667 Female, age 75, unknown 1312.7
1944 Female, age 72, unknown 1312.1
2825 Male, age 18, unknown 1304.4
2273 Male, age 74, both hemispheres 1297.3
2407 Male, age 75, both hemispheres 1282.7
Red nucleus
nTPM: 1332.2
2503 Female, age 72, unknown 1373.8
1821 Female, age 72, unknown 1353.2
2227 Male, age 72, unknown 1345.6
1904 Male, age 53, unknown 1345.1
2769 Male, age 72, unknown 1337.8
1865 Male, age 51, unknown 1336.4
2785 Male, age 18, unknown 1329.8
2725 Female, age 75, unknown 1326.8
2588 Male, age 74, left hemisphere 1319.1
1954 Female, age 42, unknown 1313.5
2584 Male, age 75, left hemisphere 1306.9
2823 Male, age 76, right hemisphere 1297.7
Substantia nigra
nTPM: 1347.8
2409 Female, age 72, unknown 1447.3
1851 Male, age 51, unknown 1403.2
2241 Male, age 72, unknown 1359.6
1916 Female, age 42, unknown 1350.7
2699 Male, age 18, unknown 1340.9
2665 Male, age 74, both hemispheres 1338.3
1889 Female, age 72, unknown 1325.4
2590 Female, age 75, unknown 1311.7
1941 Male, age 53, unknown 1307.1
2583 Male, age 75, right hemisphere 1293.8
Superior colliculus
nTPM: 1323.9
1796 Male, age 53, unknown 1350.2
1913 Female, age 42, unknown 1341.3
1995 Male, age 72, unknown 1337.2
2261 Male, age 18, unknown 1333.4
2668 Female, age 75, unknown 1331.2
2087 Female, age 72, unknown 1324.9
2587 Male, age 74, left hemisphere 1321.5
1895 Male, age 76, right hemisphere 1313.6
1839 Male, age 51, unknown 1299.3
2664 Male, age 75, both hemispheres 1286.1
Ventral tegmental area
nTPM: 1334.8
1915 Female, age 42, unknown 1368.8
2223 Female, age 72, unknown 1349.5
2410 Female, age 72, unknown 1344.9
2021 Male, age 53, unknown 1327.5
1942 Male, age 51, unknown 1316.6
2218 Male, age 76, both hemispheres 1301.7

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1620.4
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 1620.4
Samples: 139

Max nTPM: 5563.7
Min nTPM: 575.1
Std nTPM: 755.7
Median nTPM: 1436.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 5563.7
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 5094.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 4178.6
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 3897.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 3139.2
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 3075.6
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 2986.5
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 2898.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 2757.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 2725.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 2684.6
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 2646.8
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 2574.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 2496.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 2472.0
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 2461.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 2260.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 2218.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 2206.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 2185.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 2135.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 2084.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 2029.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 2022.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 2020.2
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 2018.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 2008.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 1999.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 1985.2
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 1955.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1948.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 1945.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 1938.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 1898.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 1897.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 1895.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 1865.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 1825.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 1824.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 1809.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 1776.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 1774.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 1769.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1761.0
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 1757.1
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 1756.1
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 1729.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 1725.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 1696.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 1664.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 1627.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 1619.8
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 1608.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 1595.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 1582.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 1570.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 1563.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 1554.0
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 1551.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 1546.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 1541.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 1530.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 1528.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 1525.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 1516.3
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 1481.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 1470.9
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 1465.0
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 1452.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 1436.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1413.8
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 1413.4
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 1412.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 1406.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1402.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 1394.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 1383.6
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1350.6
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 1349.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 1341.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 1340.2
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 1339.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 1329.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 1327.8
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 1313.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 1305.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 1299.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 1285.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 1283.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1277.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 1274.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 1273.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 1264.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 1264.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 1262.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 1259.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1258.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 1255.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 1239.5
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 1214.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 1185.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 1183.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 1178.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 1166.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 1146.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 1114.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1113.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1107.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 1102.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1087.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 1081.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 1079.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 1069.6
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 1064.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 1061.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 1043.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 1040.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 999.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 997.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 993.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 980.6
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 961.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 959.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 952.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 935.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 931.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 908.9
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 884.2
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 866.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 849.4
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 848.7
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 843.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 812.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 808.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 803.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 786.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 786.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 583.4
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 575.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 341.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 341.0
FF:10158-103A5 76 years, female 341.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 199.3
Pig sample Sample description nTPM
Midbrain
nTPM: 195.2
Samples: 4

Max nTPM: 300.8
Min nTPM: 116.5
Sample A Female 300.8
Sample B Female 213.9
Sample C Male 149.5
Sample D Male 116.5
Periaqueductal gray
nTPM: 143.9
Samples: 3

Max nTPM: 156.6
Min nTPM: 123.3
Sample B Female 156.6
Sample C Male 151.7
Sample D Male 123.3
Substantia nigra
nTPM: 199.3
Samples: 4

Max nTPM: 291.9
Min nTPM: 148.3
Sample A Female 291.9
Sample B Female 201.7
Sample C Male 155.3
Sample D Male 148.3
Superior colliculi
nTPM: 193.6
Samples: 4

Max nTPM: 259.1
Min nTPM: 150.1
Sample A Female 259.1
Sample B Female 201.2
Sample C Male 164.0
Sample D Male 150.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 873.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 873.8
Samples: 4

Max nTPM: 1128.8
Min nTPM: 679.2
Sample A Male 1128.8
Sample B Male 806.9
Sample C Female 679.2
Sample D Female 880.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 4.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 4.7
74425523 Antisense, RP_051214_02_E09, Mouse strain C57BL/6J (56 days, male) 7.1
68545854 Antisense, RP_050120_01_F03, Mouse strain C57BL/6J (56 days, male) 2.3

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.