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MARCKSL1
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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:504.7 nTPM
HPA:504.7 nTPM
GTEx:495.6 nTPM
FANTOM5:741.9 Scaled Tags Per Million
Pig:928.1 nTPM
Mouse:70.8 nTPM
Allen mouse:2.2 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 504.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 433.5
2411 Female, age 72, unknown 503.7
1870 Female, age 42, unknown 494.2
1833 Male, age 53, unknown 492.0
1830 Male, age 51, unknown 489.4
2828 Female, age 72, unknown 457.4
2019 Male, age 18, unknown 432.5
1827 Male, age 72, unknown 379.0
2586 Male, age 75, left hemisphere 373.1
2666 Male, age 74, left hemisphere 356.8
2219 Male, age 76, both hemispheres 356.6
Dorsal raphe nucleus
nTPM: 372.7
2750 Male, age 76, both hemispheres 504.9
2016 Female, age 72, unknown 374.4
1828 Male, age 53, unknown 364.9
2298 Female, age 72, unknown 313.6
2047 Male, age 72, unknown 305.6
Inferior colliculus
nTPM: 364.5
2849 Male, age 72, unknown 386.3
1848 Female, age 42, unknown 377.0
1890 Male, age 53, unknown 362.7
2097 Female, age 72, unknown 332.2
Median raphe nucleus
nTPM: 374.3
2220 Male, age 76, midline 374.3
Pedunculopontine tegmental nucleus
nTPM: 396.1
2334 Male, age 80, both hemispheres 439.0
1921 Female, age 85, both hemispheres 383.4
2338 Male, age 61, both hemispheres 366.0
Periaquaductal grey, anterior
nTPM: 324.9
2502 Female, age 75, unknown 353.8
1947 Male, age 18, unknown 313.4
1795 Male, age 51, unknown 307.4
Periaquaductal grey, dorsal
nTPM: 331.7
2464 Female, age 72, unknown 376.1
1831 Male, age 72, unknown 344.7
2850 Male, age 76, both hemispheres 311.0
1840 Male, age 53, unknown 295.0
Periaquaductal grey, lateral
nTPM: 329.1
2053 Male, age 18, unknown 356.5
2272 Male, age 74, both hemispheres 335.4
2140 Male, age 76, both hemispheres 295.5
Pretectal area
nTPM: 360.3
2667 Female, age 75, unknown 432.5
1815 Male, age 53, unknown 407.1
2316 Male, age 76, right hemisphere 382.9
2407 Male, age 75, both hemispheres 375.8
2825 Male, age 18, unknown 373.4
1817 Female, age 42, unknown 367.4
2273 Male, age 74, both hemispheres 342.9
2224 Female, age 72, unknown 335.6
2007 Male, age 72, unknown 333.6
1944 Female, age 72, unknown 314.2
1816 Male, age 51, unknown 297.5
Red nucleus
nTPM: 504.7
2823 Male, age 76, right hemisphere 580.2
2769 Male, age 72, unknown 574.7
2227 Male, age 72, unknown 554.7
1865 Male, age 51, unknown 546.7
1821 Female, age 72, unknown 541.7
1904 Male, age 53, unknown 540.0
1954 Female, age 42, unknown 500.6
2503 Female, age 72, unknown 494.5
2785 Male, age 18, unknown 483.5
2588 Male, age 74, left hemisphere 448.1
2584 Male, age 75, left hemisphere 413.5
2725 Female, age 75, unknown 378.0
Substantia nigra
nTPM: 362.5
2699 Male, age 18, unknown 416.4
2583 Male, age 75, right hemisphere 415.7
1851 Male, age 51, unknown 398.3
1889 Female, age 72, unknown 382.5
2409 Female, age 72, unknown 347.5
2590 Female, age 75, unknown 343.2
1941 Male, age 53, unknown 342.9
1916 Female, age 42, unknown 335.0
2665 Male, age 74, both hemispheres 326.0
2241 Male, age 72, unknown 317.4
Superior colliculus
nTPM: 391.8
1913 Female, age 42, unknown 486.4
1995 Male, age 72, unknown 479.0
2587 Male, age 74, left hemisphere 415.3
1839 Male, age 51, unknown 407.4
1895 Male, age 76, right hemisphere 406.6
2668 Female, age 75, unknown 387.4
1796 Male, age 53, unknown 363.6
2664 Male, age 75, both hemispheres 338.1
2087 Female, age 72, unknown 325.1
2261 Male, age 18, unknown 308.9
Ventral tegmental area
nTPM: 411.9
2223 Female, age 72, unknown 554.7
2410 Female, age 72, unknown 425.6
2218 Male, age 76, both hemispheres 385.3
1942 Male, age 51, unknown 372.4
2021 Male, age 53, unknown 368.4
1915 Female, age 42, unknown 365.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 495.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 495.6
Samples: 139

Max nTPM: 1260.8
Min nTPM: 135.6
Std nTPM: 199.8
Median nTPM: 466.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 1260.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 1237.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 1021.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 948.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 915.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 913.9
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 887.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 840.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 840.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 831.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 821.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 807.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 792.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 790.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 788.7
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 785.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 770.6
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 740.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 711.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 705.3
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 674.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 662.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 657.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 647.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 635.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 634.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 632.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 632.1
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 615.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 611.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 598.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 596.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 589.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 587.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 575.8
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 565.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 562.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 562.3
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 560.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 559.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 557.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 551.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 550.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 549.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 547.2
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 542.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 540.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 531.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 528.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 526.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 525.6
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 524.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 524.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 521.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 519.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 516.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 513.6
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 508.8
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 504.5
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 499.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 497.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 495.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 494.3
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 491.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 490.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 489.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 488.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 472.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 471.3
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 466.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 459.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 455.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 452.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 452.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 448.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 445.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 444.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 443.2
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 442.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 436.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 436.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 430.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 425.9
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 419.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 416.5
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 415.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 413.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 405.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 398.3
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 392.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 390.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 389.9
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 388.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 387.4
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 386.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 385.4
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 385.0
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 384.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 383.4
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 381.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 377.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 372.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 371.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 362.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 355.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 353.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 347.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 347.0
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 340.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 339.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 338.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 337.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 337.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 336.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 334.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 331.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 330.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 327.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 318.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 315.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 311.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 306.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 295.0
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 290.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 275.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 273.9
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 271.4
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 261.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 257.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 256.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 250.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 246.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 218.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 213.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 194.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 173.3
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 144.5
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 138.1
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 135.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 741.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 741.9
FF:10158-103A5 76 years, female 741.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 928.1
Pig sample Sample description nTPM
Midbrain
nTPM: 928.1
Samples: 4

Max nTPM: 2536.1
Min nTPM: 311.0
Sample A Female 2536.1
Sample B Female 539.5
Sample C Male 325.7
Sample D Male 311.0
Periaqueductal gray
nTPM: 366.9
Samples: 3

Max nTPM: 413.6
Min nTPM: 297.9
Sample B Female 413.6
Sample C Male 297.9
Sample D Male 389.2
Substantia nigra
nTPM: 597.5
Samples: 4

Max nTPM: 1020.0
Min nTPM: 285.9
Sample A Female 663.9
Sample B Female 285.9
Sample C Male 420.0
Sample D Male 1020.0
Superior colliculi
nTPM: 531.0
Samples: 4

Max nTPM: 665.6
Min nTPM: 295.7
Sample A Female 639.7
Sample B Female 295.7
Sample C Male 523.1
Sample D Male 665.6

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 70.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 70.8
Samples: 4

Max nTPM: 78.2
Min nTPM: 62.0
Sample A Male 75.7
Sample B Male 62.0
Sample C Female 67.4
Sample D Female 78.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.2
671 Antisense, RP_Baylor_102908, Mouse strain C57BL/6J (56 days, male) 4.0
670 Antisense, RP_Baylor_102908, Mouse strain C57BL/6J (56 days, male) 2.9
672 Sense, RPS_Baylor_37014, Mouse strain C57BL/6J (56 days, male) 0.3

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