Changes in metabolic pathways are frequently seen in cancer cells, and mutations in certain metabolic genes may even play a direct role in cancer development and progression. One gene for which this is true is the multi-localizing gene fumarate hydratase...Read more

Cancer-associated protein fetal and adult testis expressed 1 (gene: FATE1) is mapped to reproductive supporting cells in normal testis tissue using multiplex immunohistochemistry (mIHC/IF)...Read more

This month, the expression of beta-cell-associated transcription factor PDX1 within the endocrine pancreas is displayed through multiplex immunohistochemistry (mIHC/IF)...Read more

T cells are central drivers of inflammation across autoimmune and inflammatory diseases, yet current therapies inadequately target pathogenic T-cell pathways, limiting durable disease control. In a recent study published in Signal Transduction and Targeted Therapy, a team led by Thomas Helleday and Theodora Manolakou, identified a novel, targetable transcriptional-metabolic axis that sustains inflammatory T-cell responses. In an interview by Gustav Ceder, Helleday discusses the novel findings and ongoing lines of research...Read more

A new article in Protein Science describes the HPA Multiplex tissue resource, a spatial proteomics effort adding a new layer of high-resolution protein expression data to the HPA portal. The article presents both the methodology and the biological value of the resource, providing a scalable framework for in-depth spatial proteomics profiling of human tissues...Read more