The nucleus of mammalian cells is highly compartmentalized both in terms of DNA and protein organization. Speckles are large membrane-less irregularly shaped nuclear condensates with a dynamic composition of hundreds of different proteins, many of which are involved in RNA splicing. Evidence from recent studies points towards an interesting connection between the evolution of nuclear speckles and genome structure in terms of base composition, gene clustering and 3D-genome organization...Read more

In a review article published in Pharmacological reviews the current knowledge of molecular features, functions, and opportunities for therapeutic targeting of human and mammalian aGPCRs is summarised...Read more

In this edition of multiplex tissue image of the month, meiosis-associated BEN domain containing 2 (gene: BEND2) is showcased within developing spermatocytes in testis...Read more

In the latest episode of the new Proteomics show podcast series, "All the parts", neuroscientist at Karolinska Institute and HPA researcher Jan Mulder talks about many different aspects of the brain and brain research together with the hosts Benjamin Neely and Ben Orsburn...Read more

Easter celebration is very tightly linked to eggs and therefore we will take this opportunity to have a closer look at the zona pellucida proteins, some of the most important genes in the human oocyte...Read more