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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:2856.7 nTPM
HPA:2856.7 nTPM
GTEx:2608.4 nTPM
FANTOM5:9346.2 Scaled Tags Per Million
Pig:649.1 nTPM
Mouse:371.7 nTPM
Allen mouse:12.2 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 2856.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 2655.5
1870 Female, age 42, unknown 2898.7
2666 Male, age 74, left hemisphere 2890.1
1830 Male, age 51, unknown 2839.0
2411 Female, age 72, unknown 2820.8
1833 Male, age 53, unknown 2819.4
2019 Male, age 18, unknown 2688.0
2828 Female, age 72, unknown 2638.6
1827 Male, age 72, unknown 2391.1
2219 Male, age 76, both hemispheres 2353.4
2586 Male, age 75, left hemisphere 2216.4
Dorsal raphe nucleus
nTPM: 2383.0
2750 Male, age 76, both hemispheres 2624.3
2016 Female, age 72, unknown 2443.9
1828 Male, age 53, unknown 2407.9
2298 Female, age 72, unknown 2236.9
2047 Male, age 72, unknown 2202.1
Inferior colliculus
nTPM: 2340.5
1848 Female, age 42, unknown 2387.3
2849 Male, age 72, unknown 2350.4
1890 Male, age 53, unknown 2337.2
2097 Female, age 72, unknown 2287.3
Median raphe nucleus
nTPM: 2497.3
2220 Male, age 76, midline 2497.3
Pedunculopontine tegmental nucleus
nTPM: 2641.9
2338 Male, age 61, both hemispheres 2788.2
2334 Male, age 80, both hemispheres 2696.4
1921 Female, age 85, both hemispheres 2441.1
Periaquaductal grey, anterior
nTPM: 2253.7
1947 Male, age 18, unknown 2342.2
1795 Male, age 51, unknown 2230.5
2502 Female, age 75, unknown 2188.6
Periaquaductal grey, dorsal
nTPM: 2264.1
2464 Female, age 72, unknown 2347.6
2850 Male, age 76, both hemispheres 2321.3
1831 Male, age 72, unknown 2313.2
1840 Male, age 53, unknown 2074.4
Periaquaductal grey, lateral
nTPM: 2323.0
2053 Male, age 18, unknown 2339.1
2272 Male, age 74, both hemispheres 2322.8
2140 Male, age 76, both hemispheres 2307.0
Pretectal area
nTPM: 2373.9
1815 Male, age 53, unknown 2567.1
1817 Female, age 42, unknown 2489.2
2316 Male, age 76, right hemisphere 2412.3
2667 Female, age 75, unknown 2411.7
2273 Male, age 74, both hemispheres 2390.0
2407 Male, age 75, both hemispheres 2383.2
2825 Male, age 18, unknown 2370.0
2007 Male, age 72, unknown 2333.6
2224 Female, age 72, unknown 2318.9
1944 Female, age 72, unknown 2254.7
1816 Male, age 51, unknown 2181.8
Red nucleus
nTPM: 2856.7
1821 Female, age 72, unknown 3136.6
1904 Male, age 53, unknown 3091.6
1865 Male, age 51, unknown 3075.6
1954 Female, age 42, unknown 2970.6
2227 Male, age 72, unknown 2968.6
2503 Female, age 72, unknown 2950.5
2769 Male, age 72, unknown 2942.3
2785 Male, age 18, unknown 2854.7
2823 Male, age 76, right hemisphere 2844.6
2725 Female, age 75, unknown 2535.4
2588 Male, age 74, left hemisphere 2498.5
2584 Male, age 75, left hemisphere 2410.7
Substantia nigra
nTPM: 2427.9
2409 Female, age 72, unknown 2568.9
1851 Male, age 51, unknown 2549.1
1889 Female, age 72, unknown 2532.8
2699 Male, age 18, unknown 2490.4
2583 Male, age 75, right hemisphere 2433.0
2590 Female, age 75, unknown 2397.5
1941 Male, age 53, unknown 2387.8
2241 Male, age 72, unknown 2365.2
1916 Female, age 42, unknown 2332.0
2665 Male, age 74, both hemispheres 2222.4
Superior colliculus
nTPM: 2516.3
1913 Female, age 42, unknown 2889.6
2668 Female, age 75, unknown 2836.2
1995 Male, age 72, unknown 2812.0
2587 Male, age 74, left hemisphere 2621.9
1839 Male, age 51, unknown 2485.9
1796 Male, age 53, unknown 2427.1
1895 Male, age 76, right hemisphere 2324.2
2087 Female, age 72, unknown 2299.0
2664 Male, age 75, both hemispheres 2243.6
2261 Male, age 18, unknown 2223.7
Ventral tegmental area
nTPM: 2588.2
2223 Female, age 72, unknown 3032.7
2410 Female, age 72, unknown 2666.9
1915 Female, age 42, unknown 2491.4
2218 Male, age 76, both hemispheres 2462.6
2021 Male, age 53, unknown 2452.7
1942 Male, age 51, unknown 2422.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 2608.4
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 2608.4
Samples: 139

Max nTPM: 8387.2
Min nTPM: 733.4
Std nTPM: 1625.6
Median nTPM: 2140.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 8387.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 8216.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 8041.8
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 7445.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 7383.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 6451.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 6366.4
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 6346.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 5845.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 5677.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 5651.0
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 5504.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 5170.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 5134.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 4977.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 4650.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 4374.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 4092.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 3937.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 3914.8
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 3872.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 3829.3
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 3784.5
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 3763.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 3752.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 3748.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 3696.9
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 3634.5
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 3481.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 3470.9
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 3448.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 3320.4
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 3281.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 3230.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 3203.3
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 3157.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 3048.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 2982.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 2957.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 2949.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 2945.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 2879.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 2864.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 2847.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 2837.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 2780.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 2751.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 2747.8
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 2742.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 2618.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 2526.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 2505.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 2463.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 2389.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 2380.9
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 2376.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 2371.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 2317.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 2300.5
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 2297.1
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 2289.0
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 2265.3
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 2262.5
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 2236.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 2184.8
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 2168.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 2161.3
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 2153.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 2145.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 2140.2
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 2125.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 2102.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 2061.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 2017.3
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 1985.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 1933.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 1924.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 1924.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 1918.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 1916.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 1907.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 1900.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 1898.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 1887.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 1790.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 1784.9
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 1763.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 1752.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 1748.0
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 1743.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 1734.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 1731.4
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 1729.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 1729.2
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 1710.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 1684.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 1664.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 1638.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 1610.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 1603.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 1588.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1580.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 1563.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 1550.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 1541.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 1534.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 1529.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 1505.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 1463.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 1446.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 1427.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 1422.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 1367.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 1334.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 1331.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 1329.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 1324.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 1276.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 1262.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 1250.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 1249.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 1207.4
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 1168.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 1159.5
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 1139.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 1128.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 1124.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 1118.8
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 1042.7
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 1020.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 1004.8
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 936.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 890.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 840.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 815.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 806.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 754.4
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 745.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 733.4
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 9346.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 9346.2
FF:10158-103A5 76 years, female 9346.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 649.1
Pig sample Sample description nTPM
Midbrain
nTPM: 649.1
Samples: 4

Max nTPM: 1526.7
Min nTPM: 278.6
Sample A Female 1526.7
Sample B Female 493.8
Sample C Male 297.1
Sample D Male 278.6
Periaqueductal gray
nTPM: 352.8
Samples: 3

Max nTPM: 396.3
Min nTPM: 284.2
Sample B Female 378.0
Sample C Male 284.2
Sample D Male 396.3
Substantia nigra
nTPM: 541.4
Samples: 4

Max nTPM: 836.0
Min nTPM: 371.2
Sample A Female 576.8
Sample B Female 371.2
Sample C Male 381.4
Sample D Male 836.0
Superior colliculi
nTPM: 496.9
Samples: 4

Max nTPM: 612.2
Min nTPM: 292.6
Sample A Female 612.2
Sample B Female 292.6
Sample C Male 511.1
Sample D Male 571.6

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 371.7
Mouse sample Sample description nTPM
Midbrain
nTPM: 371.7
Samples: 4

Max nTPM: 404.1
Min nTPM: 339.8
Sample A Male 355.0
Sample B Male 339.8
Sample C Female 387.8
Sample D Female 404.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 12.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 12.2
72182998 Antisense, RP_050927_03_A08, Mouse strain C57BL/6J (56 days, male) 12.2
74357575 Antisense, RP_050927_03_A08, Mouse strain C57BL/6J (56 days, male) 10.4

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.